Complementary role of computed tomography texture analysis for differentiation of pancreatic ductal adenocarcinoma from pancreatic neuroendocrine tumors in the portal‐venous enhancement phase
Christian Philipp Reinert, Karolin Baumgartner, Tobias Hepp, Michael Bitzer, Marius Horger
Abdominal Radiology (2020) 45:750–758 doi.org/10.1007/s00261-020-02406-9
Pancreatic ductal adenocarcinoma (PDAC) and pancreatic neuroendocrine tumors (PNEN) are the two most frequently encountered pancreatic solid lesions. Approximately 60–70% of PNEN typically appear as well-defined hypervascular solid lesions in the arterial phase, which can be easily differentiated from PDAC when performing multiphasic imaging. However, PNEN can show various atypical features, including hypovascular enhancement, ill-defined margins, dilatation of pancreatic and/or biliary duct, and encasement of peripheral vessels: in this cases, the differential diagnosis with PDAC can be difficult (1).
Many patients with pancreatic lesions, however, undergo first portal-venous CT for the elucidation of the cause of cholestasis (e.g., in case of a pancreatic head mass) and of other non-specific symptoms, or the tumors are detected incidentally. Furthermore, as a progression towards malignancy is associated with derangement in vessel architecture and function, larger PNEN have a less homogenous hypervascular pattern and may show delayed contrast enhancement. Hence, pancreatic neuroendocrine tumors can be misdiagnosed as pancreatic ductal adenocarcinoma (PDAC)(2).
Therefore the aim of this study was to explore the application value of computed tomography (CT) texture analysis in differentiating pancreatic neuroendocrine tumors (PNEN) from pancreatic ductal adenocarcinomas (PDAC) in the portal-venous phase.
Texture analysis is an emerging and noninvasive method of assessing organizational characteristics, which can provide objectively quantified parameters for differential diagnosis independent of subjective analysis (3). Texture analysis can extract much more data from medical images than the naked eye by means of quantitatively analyzing greyscale distribution features, inter-pixel relations, and spatial features of images. Texture features might detect distinct quantifiable phenotypic differences of tissues which cannot be assessed through a qualitative, visual evaluation of radiological images alone. Based on these texture features, it is possible to differentiate between different tissues (4).
The study retrospectively analyzed the CT scans in the portal-venous phase (60–70 s delay) of 95 patients, 53 affected by PDAC and 42 by PNEN. Volumes of interests (VOIs) were drawn freehand by a senior radiologist with 25 years of experience in abdominal and oncologic imaging, including only the tumor tissue excluding adjacent structures. Using a commercially available software, 92 textural features were extracted including 1st, 2nd, and higher-order features, and then compared between PNEN and PDAC. Finally, radiomics analysis was used to differentiate between grades for PNEN (G2 + G3 vs G1) and PDAC (G1 vs G2 vs G3).
Compared with PNEN, PDAC had statistically lower “median”, “maximum”, “90th percentile” and “10th percentile” (p=0.0003, p=0.04, p=0.001, p=0.001, respectively). The other first-order features “energy”, “total energy” and “minimum” (p=0.00002) were significantly higher in PNEN compared to PDAC (p=0.02, p=0.0001, p=0.00002, respectively). There was no statistical significance (p >.05) for entropy between these two tumors. The 2nd order feature GLCM Imc2 was significantly higher in PDAC than in PNEN (p=0.0002). In PNEN, the higher-order feature GLSZM Small Area High Gray-Level Emphasis proved significantly higher in patients with G1 compared to patients with G2/G3 tumors (p < 05). No significant differences were found in radiomics features between different gradings of PDAC. In PNEN, the higher-order feature GLSZM Small Area High Gray-Level Emphasis was significantly higher in patients with G1 tumors compared to patients with G2/G3 tumors (p< 05). In PDAC, no significant differences were observed in textural features between patients with G1 and G2/G3 tumors. The tumor/parenchyma ratios, as well as the visual assessment into hypo-/iso-/yperdense or homogeneous/heterogeneous, did not significantly differ between PDAC and PNEN.
In conclusion, this study shows that CT-textural features quantified on portal-venous CT-image data are capable of differentiating between PDAC and PNEN, and also between G1 and G2/3 PNEN. These results may have important clinical implications as they may lead to a more individualized approach and affect clinical or surgical decisions.
 He M, Liu Z, Lin Y, Wan J, Li J, Xu K, et al. Differentiation of atypical non-functional pancreatic neuroendocrine tumor and pancreatic ductal adenocarcinoma using CT based radiomics. Eur J Radiol. 2019;117:102-11.
 Saif MW. Pancreatic neoplasm in 2011: an update. JOP. 2011;12:316-21.
 Incoronato M, Aiello M, Infante T, Cavaliere C, Grimaldi AM, Mirabelli P, et al. Radiogenomic Analysis of Oncological Data: A Technical Survey. Int J Mol Sci. 2017;18.
 Ganeshan B, Miles KA. Quantifying tumour heterogeneity with CT. Cancer Imaging. 2013;13:140-9.
Dr. Lorenzo Costa is a third-year radiology resident at University Hospital of Verona. He completed his undergraduate medical degree at the University of Bologna in 2015. He joined the Medical Imaging Department of Verona in 2017 where he is undertaking training in diagnostic and interventional radiology.
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Hepatic hemangioendothelioma: CT, MR, and FDG-PET-CT in 67 patients—a bi-institutional comprehensive cancer center review
Dhakshinamoorthy Ganeshan, Perry J. Pickhardt, Ajaykumar C. Morani, Sanaz Javadi, Meghan G. Lubner, Mohab M. Elmohr, Cihan Duran & Khaled M. Elsayes
European Radiology – January 2020 doi.org/10.1007/s00330-019-06637-3
Hepatic epithelioid haemangioendothelioma (HEH) is a rare malignant mesenchymal tumour of the liver. Its aetiology is unclear, however a number of risk factors have been implicated including liver trauma, hepatitis, asbestos and vinyl chloride exposure, OCP use and alcohol. It usually arises in the 3rd to 4th decade of life, with a reported female predilection. Diagnosis of these tumours is challenging in view of the non-specific nature of their presentation and the absence of significant serological abnormalities. They are in fact often misdiagnosed. Prior to this study, there were only a few small case series describing the cross-sectional imaging features of HEH.
One of the described imaging features of HEH is the target appearance, which reflects the histology of the lesion composed of a central core of dense fibrosis surrounded by a concentric layer of proliferating tumour cells, which is in turn often enclosed by a peripheral avascular rim. On T2 weighted MRI, HEH demonstrates a central area of high-signal intensity surrounded by a layer of low signal intensity and a mildly hyperintense outer layer. A similar target appearance is seen on DWI. On hepatobiliary-phase imaging, a central core is non-enhancing and surrounded by a layer of relatively higher signal intensity due to entrapment of contrast within fibrous stroma with a peripheral hypointense halo corresponding to the presence of tumour cells. The lollipop sign has also been described, and refers to the appearance of hepatic and portal veins tapering towards and terminating at or just within the edge of these lesions. Capsular retraction is another associated feature of HEH.
The aim of this study was to evaluate a larger cohort of patients in order to create a more validated description of the potentially specific imaging features for this tumour.
A retrospective review was carried out from records of patients with pathologically proven HHE in two major cancer institutions in the United States from 2008 to 2016. A cohort of 67 patients with a mean age of 47 years and F:M ratio of 2:1 was studied. Contrast enhanced CT examinations were available in 67 cases. Dynamic contrast-enhanced MRI was available in 30 patients, of whom hepatobiliary contrast was used in 8 patients. Diffusion-weighted MRI was available in 18 cases and FDG PET-CT in 13 patients. Imaging was retrospectively reviewed by 3 abdominal radiologists. Note was made of the number, size and location off tumours and the presence of previously reported imaging features described above.
Multifocal HHE was seen in 88% of patients and 96% demonstrated a peripheral subcapsular location. Capsular retraction was noted in 81%. These findings were similar to other studies. Tumour coalescence was seen in 61% of cases, a higher incidence when compared to other studies, possibly due to the fact that there was a higher incidence of multifocal tumours in this cohort. Peripheral ring arterial phase enhancement was present in 33% of CT cases and the targetoid appearance on portovenous phase imaging was seen in 69% of patients. MRI demonstrated heterogenous high T2 signal intensity in 97% of the cases, with the target sign being present in 67% - a higher incidence than in another study; however the latter considered only 10 patients. Diffusion restriction was seen in 61% of the patients who had DWI included which tallies with other studies. Of the 7 patients who had hepatobiliary phase MR imaging performed, the targetoid appearance was seen in 57% of cases. The lollipop sign was demonstrated in 30% of patients (other studies reported this finding in 4 - 54% of cases) and increased FDG uptake in 62% (reported as 67% in a smaller cohort study).
The authors highlight a number of limitations of this study, including this being a retrospective review associated with selection bias, as well as variation in imaging protocols used during the years of the study.
Whilst the above mentioned imaging features are not pathognomonic for HEH, as metastases and cholangiocarcinoma may also demonstrate similar findings, this study serves to validate how the described imaging features should raise the possibility of HEH, aiding in more accurate radiological diagnosis.
Dr. Stephanie Vella is a second-year radiology resident at Mater Dei Hospital, Malta. She completed her undergraduate medical degree at the University of Malta in 2015 and joined the Medical Imaging Department in 2018 where she is undertaking training in diagnostic and interventional radiology.
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CT and MR perfusion techniques to assess diffuse liver disease
Authors: Ronot M, Leporq B, Van Beers BE, Vilgrain V.
Journal: Abdom Radiol (NY). Published online 25 Nov 2019. https://doi.org/10.1007/s00261-019-02338-z
Perfusion imaging provides quantitative information about tissue microcirculation and relies on monitoring the variation of the injected contrast medium over time with the acquisition of signal intensity/time curves. Perfusion imaging in the liver permits the quantitative extraction of physiological perfusion parameters of liver microcirculation at levels far below the spatial resolution of conventional CT and MR imaging. It enables not only malignant liver tumours assessment but also the evaluation of chronic liver diseases. Liver perfusion imaging is challenging and demanding due to the dual blood supply of the liver, the fenestration of its sinusoidal capillaries and its movement during respiration.
In this comprehensive review article, the authors describe the pathophysiology of hepatic architecture and function changes in chronic liver diseases and the characteristics of liver CT and MR perfusion imaging for chronic liver disease assessment. In addition, they analyze difficulties of liver perfusion imaging and provide useful suggestions for reliable perfusion imaging analysis.
In a normal liver, portal perfusion varies over time depending on the splanchnic venous flow and respiratory movements. When portal perfusion decreases, arterial blood supply increases (1). In patients with chronic liver disease, chronic liver injuries lead to progressive deposition of extravascular fibrous tissue that causes capillarization of the sinusoids, intrahepatic vascular resistance increase and eventually portal venous perfusion decrease (2). This decrease is only partially compensated by an increase in arterial blood supply resulting in global liver perfusion decrease.
High spatial and temporal resolution and whole liver imaging are the most important requirements that should be fulfilled in order to perform reliable liver perfusion analysis with CT and MR (3).
The main advantages of CT perfusion imaging are low cost, high spatial and temporal resolution and accurate measurement of tracer concentrations. To obtain reliable CT perfusion imaging analysis, the quality of injection and the reduction of respiratory artefacts are of utmost importance. The authors suggest contrast agent injection (350mg of iodine/mL) at a rate of 4 mL/s and slow and superficial breathing.
The most common technique used for MR perfusion imaging is dynamic contrast-enhanced imaging (DCE imaging). In order to achieve high temporal resolution and to reduce motion sensitivity, partial k-space updating methods are used combined with partial Fourier and parallel imaging. To avoid signal enhancement saturation at high concentrations, low contrast agent concentrations (0.025 mmol/kg) and/or lower injection rates are recommended. The intravoxel incoherent motion (IVIM) model of diffusion-weighted MR imaging can also be used to calculate microperfusion without contrast injection.
Analysis of hepatic perfusion is performed with a semi-quantitative and a quantitative mathematical approach. The first is based on the analysis of the shape of the signal intensity/time curves and the latter on various pharmacokinetic models, that allow calculation of various parameters such as perfusion and extraction fraction.
Temporal noise caused by respiratory motion is the main difficulty of liver perfusion imaging. The use of coronal views, registration-based motion correction methods and motion insensitive pulse sequences such as golden-angle radial sparse parallel (GRASP) can help overcome this problem (4).
Perfusion imaging in the liver is usually performed with extracellular contrast agents, which enable discrimination of patients with various stages of liver fibrosis (5) since perfusion alteration is correlated with the severity of portal hypertension and the degree of liver dysfunction (6). Recently, hepatobiliary contrast agents have been introduced, allowing quantification of both liver perfusion and hepatocyte transport function (7). In chronic liver disease, liver signal intensity decrease is observed during the hepatobiliary phase, and pharmacokinetic rate constants decrease during dynamic MR (8). It has been shown that changes in the hepatocyte transfer rates are earlier markers of liver fibrosis than perfusion parameters (9). Finally, the IVIM model of diffusion MR is another technique that enables liver perfusion evaluation. In patients with liver cirrhosis, an ADC decrease is observed compared with controls due to changes in microperfusion (10).
Overall, the authors provide an important review and enhance the latest knowledge on perfusion imaging of the liver, highlighting its complementary role in assessing the severity of cirrhosis and portal hypertension. The authors also suggest that MR perfusion with the use of hepatobiliary contrast agents is very promising since it can help in recognition of earlier stages of chronic liver disease.
1. Itai Y, Matsui O (1997) Blood flow and liver imaging. Radiology 202 (2):306-314. https ://doi.org/10.1148/radio logy.202.2.9015047
2. Friedman SL (2003) Liver fibrosis – from bench to bedside. J Hepatol 38 Suppl 1:S38-53
3. Pandharipande PV, Krinsky GA, Rusinek H, Lee VS (2005) Perfusion imaging of the liver: current challenges and future goals. Radiology 234 (3):661-673. doi.org/10.1148/radio l.2343031362
4. Weiss J, Ruff C, Grosse U, Grozinger G, Horger M, Nikolaou K, Gatidis S (2019) Assessment of Hepatic Perfusion Using GRASP MRI: Bringing Liver MRI on a New Level. Invest Radiol. https ://doi.org/10.1097/rli.00000 00000 00058 6
5. Ronot M, Asselah T, Paradis V,Michoux N, Dorvillius M, Baron G, Marcellin P, Van Beers BE, Vilgrain V (2010) Liver fibrosis inchronic hepatitis C virus infection: differentiating minimal from intermediate fibrosis with perfusion CT. Radiology 256 (1):135- 142. https ://doi.org/10.1148/radio l.10091 295
6. Annet L, Materne R, Danse E, Jamart J, Horsmans Y, Van Beers BE (2003) Hepatic flow parameters measured with MR imagingand Doppler US: correlations with degree of cirrhosis and portal hypertension. Radiology 229 (2):409-414. https ://doi.org/10.1148/radio l.22920 21128
7. Van Beers BE, Garteiser P, Leporq B, Rautou PE, Valla D (2017) Quantitative Imaging in Diffuse Liver Diseases. Semin Liver Dis 37 (3):243-258. doi.org/10.1055/s-0037-16036 51
8. Lagadec M, Doblas S, Giraudeau C, Ronot M, Lambert SA, FasseuM, Paradis V, Moreau R, Pastor CM, Vilgrain V, Daire JL, Van Beers BE (2015) Advanced fibrosis: Correlation betweenpharmacokinetic parameters at dynamic gadoxetate-enhanced MR imaging and hepatocyte organic anion transporter expression in rat liver. Radiology 274 (2):379-386.https ://doi.org/10.1148/radio l.14140 313
9. Leporq B, Daire JL, Pastor CM, Deltenre P, Sempoux C, Schmidt S, Van Beers BE (2018) Quantification of hepatic perfusion and hepatocyte function with dynamic gadoxetic acid enhanced MRI in patients with chronic liver disease. ClinSci (Lond) 132 (7):813-824. https ://doi.org/10.1042/cs201 71131
10. Yoon JH, Lee JM, Baek JH, Shin CI, Kiefer B, Han JK, Choi BI (2014) Evaluation of hepatic fibrosis using intravoxel incoherent motion in diffusion-weighted liver MRI. J Comput Assist Tomogr38 (1):110-116. https ://doi.org/10.1097/rct.0b013e3182a589be
Dr. Ekaterini Xinou, PhD, is a consultant radiologist at the Computed Tomography Department of ‘Theagenion’ Cancer Hospital in Thessaloniki, Greece. She is an active ESGAR member since 2005, attending regularly annual meetings and workshops. Her main interest is in abdominal and oncologic radiology, and also in swallowing disorders. She completed her thesis at the Aristotle University of Thessaloniki regarding swallowing disorders encountered during videofluoroscopy in head and neck cancer patients after chemoradiotherapy.
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CT and MR imaging of chemotherapy-induced hepatopathy.
Authors: Vernuccio F, Dioguardi Burgio M, Barbiera F, Cusmà S, Badalamenti G, Midiri M, Vilgrain V, Brancatelli G.
Journal: Abdom Radiology (NY) 2019 Oct;44(10):3312-3324
doi: 10. 1007/s00261-019-02193-y.
Chemotherapy-induced hepatopathy results in a wide spectrum of parenchymal and vascular hepatic changes, which subsequently may either hide or mimic liver metastases on imaging. Both situations of false negative and false positive imaging diagnosis of liver metastases in oncologic patients have great clinical implications resulting in correct management strategies. Knowledge of the imaging patterns of chemotherapy induced hepatopathies is crucial in order to avoid diagnostic errors and overcome diagnostic challenges that Radiologists may face.
In this comprehensive review article, the authors explore the broad spectrum of chemotherapy-induced liver hepatopathy on CT and MR imaging. In addition, they emphasize the role of imaging in early recognition of certain chemotherapy- induced hepatopathies that are related to poor patient outcome and increased post-operative risk.
Chemotherapy-induced hepatopathies, are categorized as diffuse, mainly including liver steatosis, steatohepatitis, pseudocirrhosis and sinusoidal obstruction and focal hepatopathies. The mechanism of hepatic changes induced by chemotherapy is very well explained and imaging patterns on CT and MRI are reviewed with specific or less specific-indirect findings. Strengths and weaknesses of imaging on each modality are discussed and the beneficial role of MRI with the use of hepatobiliary agents is highlighted throughout the article in both diffuse and focal hepatopathies induced by chemotherapy.
In terms of chemotherapy-induced diffuse hepatopathy, chronic hepatocellular injury results in pseudocirrhosis, exhibiting CT and MR features similar to those of cirrhosis. Early recognition of pseudocirrhosis and portal hypertension on imaging is important, as they are related to poor patient outcome and so chemotherapy may be either discontinued or altered (1).
In chemotherapy induced liver steatosis, mainly due to irrinotecan, a main consideration is depiction of liver metastases in background fatty changes. This may be problematic on CT, however MRI, especially with the use of hepatobiliary agents, appears to be a problem-solving tool (2).
Pre-operative chemotherapy-induced steatohepatitis is a serious complication that should be specifically addressed and identified on imaging, as it clearly relates to increased post-operative morbidity and mortality (3). While quantification of fatty infiltration may be accurately provided on MR by calculating proton density fat fraction (PDFF), quantifying hepatic inflammation at present, is a weak point of imaging. Promising MRI advances however are discussed, though validation is still missing.
In chemotherapy-induced sinusoidal changes, sinusoidal obstruction syndrome-SOS being the most common, the authors emphasize the role of imaging in early detection, especially in colon cancer patients receiving pre-operative oxaliplatin-based chemotherapy. Clinical importance of identifying hepatic SOS on imaging is huge, considering that this potentially life-threatening syndrome is associated with major postoperative morbidity, reduced functional liver remnant and increased complication rate after major hepatectomy (4).
Imaging patterns of SOS are reviewed, including indirect signs due to reduced liver outflow and portal hypertension, enhancement abnormalities on contrast enhanced imaging and specific findings on Gadoxetic acid MRI, which is a sensitive and highly specific tool for diagnosing this life-threatening condition (5,6).
Chemotherapy-induced focal hepatopathies, is a relatively new challenge for Radiologists, that may result in false positive findings of liver metastases and subsequent unnecessary biopsies.
Post chemotherapy nodular hyperplasia, multiacinar regenerative nodules-FNH-like lesions in specific, hepatic peliosis and less frequently SOS presenting as focal hepatopathy, may be misdiagnosed as liver metastases. MR imaging with the use of hepatobiliary agents and diffusion-weighted imaging is very helpful in correct lesion characterization, thus preventing misdiagnosis (7,8). Liver biopsy, as suggested by the authors, is indicated for the characterization of atypical focal lesions only, such as atypical FNH-like lesions and peliosis as well as for grading suspected SOS when major hepatectomy is planned.
Weaknesses of imaging in chemotherapy-induced hepatopathy mainly include acute hepatocellular injury, due to non-specific imaging findings, post-chemotherapy monoacinar regenerative nodules, which are too small to characterize on imaging and precise quantification of steatohepatitis.
Overall, this review article in a very educational and comprehensive manner focuses on diagnostic challenges that arise in oncologic patients due to chemotherapy-induced hepatopathies. These challenges have important clinical implications as they may lead to incorrect management strategies and affect clinical or surgical decisions. Thorough knowledge of imaging patterns of chemotherapy-induced hepatopathy is crucial in order to avoid diagnostic errors and to obtain a clear clinical picture.
Dr Kyriaki Tavernaraki is a Consultant Radiologist in Imaging and Interventional Radiology Department, “Sotiria” Hospital, Athens, Greece. She completed her subspecialty training in Upper GI and Hepatobiliary and Pancreas Imaging at the Royal Free Hospital and University College London Hospital (UCLH), NHS, London, UK. She is a PhD and MSc degree holder. She is also an ESGAR member since 2015.
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Pancreaticobiliary involvement in treated type 1 autoimmune pancreatitis: Imaging pattern and risk factors for disease relapse.
Liang Zhua, Hua-dan Xuea, Wen Zhangb, Qiang Wangc, Bei Tanc, Ya-min Laic, Wei-yang Zhengc, Patrick Asbachd, Bernd Hammd, Timm Deneckee, Zheng-yu Jina.
Eur Radiol. 2019 Nov. doi: 10.1016/j.ejrad.2019.108673
Dr. Veronica Aquilina, Higher Specialist Trainee, Mater Dei Hospital, Msida/MT
Dr. Kelvin Cortis, Consultant Radiologist, Mater Dei Hospital, Msida/MT
Automimmune pancreatitis (AIP), a distinct form of chronic pancreatitis first described in 1995 by Yoshika et al., comprises two clinical entities which differ both clinically and histologically. Type 1 AIP is the pancreatic manifestation of IgG4-related systemic disease which responds favorably to corticosteroid therapy [1,2]. On the other hand, the high relapse rates with which it is associated may pose a diagnostic challenge not only because of different imaging characteristics to the original lesions but also because recurrence may mimic other pathologies such as pancreatic cancer and cholangiocarcinoma.
The aim of the study carried out by Zhua et al. was to investigate the imaging characteristics, incidence and etiology of pancreaticobiliary lesions identified on follow-up imaging in patients who had previously received steroid therapy for type 1 AIP. A total of 103 patients diagnosed with type 1 AIP, treated with steroids and who underwent regular clinical and radiological follow-ups, were included prospectively in the study.
The key results showed a high relapse rate of 42.7% with a median time interval of 17 months from the initial diagnosis. Median follow-up time was of 38 months. The majority developed on discontinuation of steroids (63.6%) whilst the rest developed on either maintenance therapy or during weaning. All lesions responded partially or completely to corticosteroid therapy and none of these were proven to be a pancreatic tumor or cholangiocarcinoma.
Whilst 34.1% were asymptomatic, the majority of patients presented with symptoms including painless jaundice, abdominal pain and weight loss. In terms of imaging patterns, pancreatic involvement was noted to be less frequent at relapse (81% as opposed to all patients at initial diagnosis) whilst bile duct involvement was common both at initial diagnosis and recurrence (81.8% vs 72.7%). 11.4% developed lesions in new organs whilst 88.6% developed in the same organ as on initial presentation.
Most patients (34.1%) relapsed in pancreaticobiliary segments previously involved whilst the remaining developed in new segments. Whilst diffuse pancreatic swelling was more common on initial presentation, the majority of recurrences (66.7%) presented as focal lesions on a background of pancreatic atrophy. Multifocal strictures involving both the distal and proximal bile ducts was the commonest manifestation of disease both at initial presentation and at relapse. Solitary bile duct strictures on the other hand were commoner amongst the relapsed cohort. The severity of bile duct thickening was also worse at relapse.
Risk factors that could predict recurrence included male sex, higher serum IgG4 level and extrapancreatic bile duct involvement on initial presentation, and a lower response ratio of serum IgG4 at the induction phase were commoner in the relapsed group.
The authors highlighted a number of limitations of the study including that this was a single center study, that the length of follow up and the cohort size were insufficient to assess the risk factors and imaging characteristics of pancreaticobiliary malignancy in AIP patients, that it did not address the risk of relapse of different therapy options and that comparative measurements of bile duct thickness at initial presentation and relapse may not be accurate as these may involve different locations.
In conclusion, pancreaticobiliary lesions in patients with previously treated type 1 AIP are common. Although the imaging characteristics may differ from the original lesions these usually represent disease recurrence rather than malignancy. Factors which confer a higher risk of relapse are namely extra-pancreatic bile duct involvement and poorer lower response ratio of serum IgG4 serum response at the induction phase.
Dr. Veronica Aquilina is a fourth-year radiology resident at Mater Dei Hospital, Malta. She completed her undergraduate medical degree at the University of Malta in 2010 and has just been admitted as a fellow of the Royal College of Radiologists (RCR), UK. Veronica has a broad range of interests in diagnostic imaging and plans to subspecialized in cardiothoracic imaging.
CT radiomics associations with genotype and stromal content in pancreatic ductal adenocarcinoma
Authors: Attiyeh MA, Chakraborty J, McIntyre CA, Kappagantula R, Chou Y, Askan G, Seier K, Gonen M, Basturk O, Balachandran VP, Kingham TP, D'Angelica MI, Drebin JA, Jarnagin WR, Allen PJ, Iacobuzio‐Donahue CA, Simpson AL, Do RK.
Journal: AbdomRadiol (NY). 2019 Jun 26. doi: 10.1007/s00261-019-02112-1. PubMed PMID: 31243486.
Prof. Andrea Laghi, ESGAR Vice President and Head of the Abdominal Radiology Department, and Dr. Elena Lucertini, ESGAR Member and radiology resident, Department of Radiological, Oncological and Pathological Sciences University of Rome "Sapienza" Radiology Unit - Sant'Andrea University Hospital, (Rome, Italy).
Dr. Riccardo Ferrari, ESGAR Education Committee Member, working in the Department of Emergency Radiology at San Camillo–Forlanini Hospital (Rome, Italy).
The paper correlates texture analysis of CT exams of the pancreas with the genomic and histological type of pancreatic cancers with promising results in differentiating histological type and stromal content; that information affects the patients' prognosis and treatment.
Pancreatic cancer is the 11th most common cancer in the world, and it is one of the most common causes of cancer-related death . In particular, pancreatic ductal adenocarcinoma (PDAC) is the most common primary pancreatic malignancy . At the time of the diagnosis, less than 20% of patients affected by PDAC are surgical candidates and many of the patients who undergo surgery, develop local recurrence . Some studies have demonstrated a relationship between gene mutations in PDAC (the most common of which are in KRAS, TP53, CDKN2A and SMAD4) and the prognosis after treatment [4, 5]. Early and non-invasively gene mutations identification in PDAC could be useful as a predicting factor of response to therapy and, furthermore, to eventually develop targeted immunotherapies .
Radiomic tools applied to pancreatic adenocarcinoma have been already evaluated in the literature to predict survival rate [7, 8]; furthermore, radiogenomics has been applied to evaluate the alternative lengthening of telomeres phenotype in pancreatic neuroendocrine tumours . Attiyeh and colleagues' study exposed in this paper the use of radiomic to identify gene mutations in PDAC. Moreover, they used radiomic features also to predict the quantity of stromal component of the tumour, having a potential role in adapting treatment modalities to the amount of stromal component .
The study retrospectively analysed preoperative CT scans of 35 patients affected by PDAC who underwent surgical tumour resection. Immunohistochemistry staining for TP53, CDK2NA and SMAD4 and a targeted sequencing of DNA were performed on resected tumour specimens, percentages of the stromal component were evaluated in a semiquantitative manner. KRAS and CDK2NA alterations were not included in the analysis because of their high frequency (approximately 90%). An alteration in SMAD4 was observed in 16/35 patients (46%), and altered expression of TP53 was found in 29/35 patients (83%).
A contrast-enhanced CT examination of the pancreatic tumour was obtained, and the tumour images were manually segmented in the portal venous phase. 255 radiomic features were extracted from the segmented volume, averaging features extracted from each axial slice, using gray-level co-occurrence matrices (GLCM), run-length matrices (RLM), local binary patterns (LBP), fractal dimension (FD), intensity histogram (IH) and angle co-occurrence matrices (ACM).
Discriminatory features were investigated for four variables: SMAD4 status (normal vs abnormal), TP53 status [wildtype (WT) vs gain of function (GOF) vs loss of function (LOF)], number of genes altered (less than or equal to and greater than 4, which resulted to be the median number of mutations in analysed patients) and quantity of stromal content.
For SMAD4 and TP53 alterations, discriminatory radiomic features were selected by using fuzzy minimum-redundancy-maximum-relevance (fMRMR) and Kruskal-Wallis test respectively and in both case a multidimensional scaling (MDS) plot with the selected features (a total of 28 for SMAD4 and 32 for TP53) was created, demonstrating a good capacity in discriminating normal SMAD4 vs abnormal SMAD4 and GOF and LOF of TP53, while a not clear power was observed in distinguishing WT from abnormal TP53 status.
fMRMR was used to identify 14 significant radiomic features able to differentiate tumours with ≤ 4 from> 4 altered genes, and MDS plot showed a good discriminating power of selected features in this case too.
Lastly, radiomic features are capable of assessing stromal content of PDAC by mean of univariate analysis, obtaining a total of 14 features; that features underwent further multivariate analysis obtaining a continuous prediction model with an R2value of 0.731, demonstrating a solid correlation between selected radiomic features and the quantity of stromal component of PDAC.
The weak point of the study is the small sample size and the possible technical variance due to the different CT protocols; that limits are common to all literature about radiomic.
In conclusion, this study, despite the limits demonstrates that radiomic features can predict SMAD4 and TP53 alterations in PDAC and the tumour stromal content; these results allow not only to predict response to therapy and survival but also to develop specific targeted therapy.
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4. Singh, P., R. Srinivasan, and J.D. Wig, SMAD4 genetic alterations predict a worse prognosis in patients with pancreatic ductal adenocarcinoma. Pancreas, 2012. 41(4): p. 541-6.
5. Xu, J.Z., et al., The Loss of SMAD4/DPC4 Expression Associated with a Strongly Activated Hedgehog Signaling Pathway Predicts Poor Prognosis in Resected Pancreatic Cancer. J Cancer, 2019. 10(17): p. 4123-4131.
6. Knudsen, E.S., et al., Stratification of Pancreatic Ductal Adenocarcinoma: Combinatorial Genetic, Stromal, and Immunologic Markers. Clin Cancer Res, 2017. 23(15): p. 4429-4440.
7. Eilaghi, A., et al., CT texture features are associated with overall survival in pancreatic ductal adenocarcinoma - a quantitative analysis. BMC Med Imaging, 2017. 17(1): p. 38.
8. Sandrasegaran, K., et al., CT texture analysis of pancreatic cancer. Eur Radiol, 2019. 29(3): p. 1067-1073.
9. McGovern, J.M., et al., CT Radiogenomic Characterization of the Alternative Lengthening of Telomeres Phenotype in Pancreatic Neuroendocrine Tumors. AJR Am J Roentgenol, 2018. 211(5): p. 1020-1025.
10. Neesse, A., et al., Stromal biology and therapy in pancreatic cancer: a changing paradigm. Gut, 2015. 64(9): p. 1476-84.
Dr. Elena Lucertini is a radiology resident at the University of Rome "Sapienza" - Sant'Andrea University Hospital in Rome, attending the second year of residency. Her main field of interest is abdominal radiology, in particular pancreas. She already worked in this area during the residency, and in the coming year, she will attend a fellowship at the Karolinska Institutet in Stockholm to more improve her skills in pancreatic radiology.
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Comparison between M-score and LR-M in the reporting system of contrast-enhanced ultrasound LI-RADS
Li-Da Chen, Si-Min Ruan, Yuan Lin, Jin-Yu Liang, Shun-Li Shen, Hang-Tong Hu, Yang Huang, Wei Li, Zhu Wang, Xiao-Yan Xie, Ming-De Lu, Ming Kuang, Wei Wang
Eur Radiol (2019) 29: 4249. https://doi.org/10.1007/s00330-018-5927-8
Dr. Joana Ferreira Pinto, 3rd year Radiologist Resident, Department of Radiology, Oporto Hospital and University Centre, Oporto (Portugal).
Prof. Dr. Manuela França, Hospitalar Assistant and Head of Radiology Department, Oporto Hospital and University Centre, Oporto (Portugal).
The distinction between intra-hepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) in high-risk patient has been a challenge all over the time for identifying HCC in focal liver lesions. Although contrast-enhanced ultrasound (CEUS) showed initial problems for this purpose, it has recently emerged as a promising technique. In 2016, an initial version of CEUS Liver Imaging Reporting and Data System (LI-RADS) was announced by The American College of Radiology (ACR) with the main goal of achieving high specificity for HCC diagnosis in LR-5 lesions, without the need of biopsy. A category of LR-M was also introduced for the inclusion of a group of lesions which were either definitely or probably malignant. Although this categorization has shown a high positive predictive value (PPV) of 98.5% for the detection of HCC , some concerns remain about the accuracy in ICC detection.
Chen LD et al aimed to develop a CEUS M-score that could be used to accurately predict the risk of ICC in high-risk patients and compared it with LR-M in CEUS LI-RADS. Also, they assessed the diagnostic performance of HCC and ICC with the modified CEUS LI-RADS.
Their retrospective study included 105 high-risk patients with HCC and 105 with ICC selected by propensity score matching between November 2003 and December 2017. The CEUS features evaluated in all patients were the following: the number of the lesions; maximum diameter of the target nodule; shape of the nodule; boundary of the lesion; enhancement level in the arterial/portal/late phase; enhancement patterns of the lesion in the arterial phase; time of enhance onset; washout time; duration of enhancement; tumour supply artery; peripheral circular artery; intratumoural vein; boundary of the intratumoural non-enhanced area; and marked washout.
Among these, the most useful CEUS independent variables for predicting ICC were poorly circumscribed (69.52%), rim enhancement (63.81%), early washout (92.38%), intratumoural vein (56.19%), obscure boundary of intratumoural non-enhanced area (57.14%) and marked washout (59.05%, all p<0,001). A M-score was developed and supported by the previous listed independent variables, using a method of least absolute shrinkage and selection operator (LASSO) regularized regression for predicting ICC. The M-score was validated and used to develop a modified CEUS LI-RADS in which the typical LR-M category was replaced by the new M-score. This modified CEUS LI-RADS was used for diagnosing lesions as HCC and ICC in comparison to the ACR CEUS LI-RADS using LR-M.
The M-score had a higher specificity (88.57% vs. 63.81%) with lower sensitivity (89.52% vs. 95.24%) compared with LR-M for detecting ICC. According to Wilson SR et al , the majority of LR-M nodules refer to ICC, and in this study the use of M-Score greatly improved specificity in the diagnosis of ICC.
Another important result in this study was the differentiation in the vascular architecture of both tumours. The HCC showed a singular vascular feature of a peripheral circular artery around the tumour , which had a high specificity (97.1%) and could be an additional ancillary feature in CEUS LI-RADS.
The authors recognized some limitations, such as not including benign lesions or other rare liver cancers for validating the diagnostic accuracy of the CEUS LI-RADS. In particular, the inclusion of combined HCC-ICC should be done in future studies. Moreover, it was a single center study and they did not compare the diagnostic performance of CEUS with other modalities as MRI/CT.
In conclusion, the authors proposed a CEUS M-score for predicting ICC in high-risk patients, with higher specificity than ACR LI-RADS. Nevertheless, the original intent of the CEUS LI-RADS classification was to achieve high specificity to HCC diagnosis, close to 100%. When using the modified CEUS LI-RADS, the sensitivity for diagnosing HCC is improved, but consequently the specificity is reduced. Therefore, it is important to understand that it should be still regarded as a complementary tool to ACR LI-RADS, which remains the most effective tool for the detection of HCC with high specificity, obviating the need for biopsy. Multicenter and prospective research will be necessary to validate the applicability of the proposed CEUS M-score.
 E. Terzi et al., “Contrast ultrasound LI-RADS LR-5 identifies hepatocellular carcinoma in cirrhosis in a multicenter restropective study of 1,006 nodules,” J. Hepatol., 2018.
 S. Wilson, A. Lyshchik, and F. Piscaglia, “CEUS LI-RADS: algorithm, implementation, and key differences from CT/MRI,” Abdom Radiol, vol. 43, pp. 127–142, 2018.
 C. Dietrich, X. Cui, B. Boozari, M. Hocke, and A. Ignee, “Contrast-Enhanced Ultrasound (CEUS) in the Diagnostic Algorithm of Hepatocellular and Cholangiocellular Carcinoma, Comments on the AASLD Guidelines,” Ultraschall der Medizin - Eur. J. Ultrasound, 2013.
Dr. Joana Ferreira Pinto is a 3rd year radiology resident at the Centro Hospitalar Universitário do Porto, in Portugal. She completed her undergraduate medical degree at the Instituto de Ciências Biomédicas Abel Salazar in 2015. She is an active member of the ESGAR and regularly attends ESGAR workshops and annual meetings. She also participated in the last Junior ESGAR Summer School in Malta. She has been developing particular interest in diagnostic abdominal radiology, especially in liver imaging.
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Diagnostic Accuracy of Whole-Body MRI Versus Standard Imaging Pathways for Metastatic Disease in Newly Diagnosed Colorectal Cancer: the Prospective Streamline C Trial
Stuart A Taylor, Sue Mallett, Sandy Beare, Gauraang Bhatnagar, Dominic Blunt, Peter Boavida, John Bridgewater, Caroline S Clarke, Marian Duggan, Steve Ellis, Robert Glynne-Jones, Vicky Goh, Ashley M Groves, Ayshea Hameeduddin, Sam M Janes, Edward W Johnston, Dow-Mu Koh, Anne Miles, Stephen Morris, Alison Morton, Neal Navani, John O’Donohue, Alfred Oliver, Anwar R Padhani, Helen Pardoe, Uday Patel, Shonit Punwani, Laura Quinn, Hameed Rafiee, Krystyna Reczko, Andrea G Rockall, Khawaja Shahabuddin, Harbir S Sidhu, Jonathan Teague, Mohamed A Thaha, Matthew Train, Katherine van Ree, Sanjaya Wijeyekoon, Steve Halligan.
Lancet Gastroenterol Hepatol 2019; 4: 529–37
Prof. Søren Rafaelsen and Dr. Leo Nygaard – Department of Radiology, Vejle University Hospital, Clinical Cancer Centre, Institute of Regional Health Research, University of Southern Denmark, Denmark
This study is an impressive prospective multicentre trial with the aim to clarify and directly compare the diagnostic accuracy and efficiency of WB-MRI-based staging pathways with standard pathways in colorectal cancer. The study patients had both WB-MRI plus all standard staging investigations performed in the period from 2013 to 2016. WB-MRI included diffusion, T2-weighted, and T1-weighted pre-intravenous and post-intravenous gadolinium contrast imaging with an examination time less than one hour. The radiologists interpreting the standard staging investigations were blinded to the WB-MRI and vice versa for the MRI radiologist. A total of 299 patients had all examinations performed, 23 % of these had synchronous metastases. The sensitivity was 63% for the standard pathway and 67% for WB-MRI. Both methods had high specificity for metastatic disease. The WB-MRI pathway had a similar agreement for T stage compared with the standard pathway. The overall time to complete staging was shorter for WB-MRI and required fewer additional tests. The staging costs were lower for WB-MRI than for standard pathways. The authors also suggest research WB-MRI in the assessment of treatment response and follow-up.
According to this study WB-MRI seems to be an efficient and safer alternative to multimodality staging pathways that does not compromise the accuracy of the existing method. Other studies with a limited number of patients have previously focused on MRI accuracy of local staging and found a high accuracy using MRI. Further studies on the accuracy of WB-MRI with focus on both local staging and distant metastases are however needed and development of an optimal protocol for both staging local and distant disease with a reasonable examination time. WB-MRI is already recommended by the International Myeloma Working Group for patients with multiple myeloma and solitary plasmacytoma. The present pioneering multicenter WB-MRI study by Taylor et al. also provides hope for better and faster staging of colon cancer at a time when survival for rectum cancer has surpassed that of colon cancer patients.The main limitation of the study was the relatively short follow-up period, but the subsequent correspondence from the authors showed no interval (missed) cancers between 24-36 months. However, it is reasonable to assume that in a symptomatic population, any missed symptomatic CRC’s would be identified within 2 years from initial presentation.
The authors should be commended for their work in developing such a substantial service. This study highlights that a CTC led symptomatic service in a single centre can achieve comparable performance data to that of a large multicentre trial like SIGGAR, while also balancing common arguments against CTC including the perceived radiation risk and additional costs, with the benefit of assessing for extra-colonic pathology. CTC is a viable, cost saving and pragmatic alternative to colonoscopy in this cohort of symptomatic patients at a time when endoscopy services are overwhelmed and cancer related targets are becoming increasingly difficult to achieve.
1. Taylor SA, Mallett S, Beare S et al. Diagnostic Accuracy of Whole-Body MRI Versus Standard Imaging Pathways for Metastatic Disease in Newly Diagnosed Colorectal Cancer: the Prospective Streamline C Trial. Lancet Gastroenterol Hepatol 2019; 4: 529–37
2. Nerad E, Lambregts DM, Kersten EL et al. MRI for Local Staging of Colon Cancer: Can MRI Become the Optimal Staging Modality for Patients With Colon Cancer? Dis Colon Rectum. 2017;60:385-392
3. Dam C, Lindebjerg J, Jakobsen A et al. Local staging of sigmoid colon cancer using MRI. Acta Radiol Open. 2017;6:2058460117720957
4. Lai AYT, Riddell A, Barwick T et al. Interobserver agreement of whole-body magnetic resonance imaging is superior to whole-body computed tomography for assessing disease burden in patients with multiple myeloma. Eur Radiol. 2019 Jul 2. doi: 10.1007/s00330-019-06281-x. [Epub ahead of print]
Dr. Leo Nygaard graduated as a medical doctor from the University of Southern Denmark in January 2016. During his medical studies he authored a paper on biological treatment with Omalizumab for severe allergic asthma and he presented his scientific studies at the Danish Society of Respiratory Medicine’s annual meeting. Leo has previously worked at the Department of Infectious and Respiratory Medicine as well as the Department of Surgery in the region of Southern Denmark. He is particularly interested in abdominal and interventional radiology and is currently working as a second-year radiology resident at the Department of Radiology, Vejle University Hospital, Clinical Cancer Centre, Denmark.
Comments may be sent to: Leo.Nygaard4@remove-this.rsyd.dk
Straight-to-test faecal tagging CT colonography for exclusion of colon cancer in symptomatic patients under the English 2-week-wait cancer investigation pathway: a service review.
J.A. Stephenson, J. Pancholi, C.V. Ivan, J.H. Mullineux, H. Patel, R. Verma, M. Elabassy.
Clinical Radiology, Volume 73, Issue 9, 2018.
Dr. Adam Laverty
Radiology ST4, St James’s University Hospital, Leeds Teaching Hospitals, Leeds, UK.
Dr. Damian Tolan
ESGAR Fellow and Clinical Lead for CT and GI/HPB imaging, St James’s University Hospital, Leeds Teaching Hospitals, Leeds, UK.
The stage of colorectal cancer (CRC) at the time of diagnosis has a major impact on survival. UK NICE guidelines and the English NHS 2 week wait (2WW) pathway aim to improve the prognosis and survival through early diagnosis of CRC. Symptomatic patients in primary care are referred directly for assessment in secondary care or straight to test (STT) colonoscopy via the 2WW pathway. However, this has placed substantial demands upon endoscopy services.
The University Hospitals of Leicester developed a CT colonography (CTC) radiology based investigation pathway for the detection of CRC in symptomatic patients with those meeting the following criteria being referred for STT:
• >60 years old
• Change in bowel habit and/or iron deficient anaemia
• World Health Organisation Performance status of 2 or better
To the publishing authors’ knowledge, this was the first pathway where STT CTC had replaced colonoscopy in such a population. The authors of the article present their experience and prospectively collected data in the first 12 months of using this pathway.
In total there were 2,072 requests for a 2WW STT CTC from primary care of which 1792 were performed. Only one complication was attributed to CTC related to a single case of perforation secondary to insufflation and only 1.6% of the studies were non-diagnostic.
In terms of the colonic findings, performance data is comparable to the SIGGAR multicentre randomised controlled trial1 with a CRC detection rate of 4.9% (versus 5.6%) and large polyp (≥10mm) detection rate of 8.3% (versus 5.1%). Suspicious colonic findings including indeterminate thickening and active colitis were seen in 3.9%. All of these patients were referred for subsequent endoscopic evaluation. A further 29 patients required another colonic test (CTC or colonoscopy) due to a non-diagnostic CTC examination. In total, the rate of additional colonic investigation was 20% (compared to 30% in the SIGGAR trial). In subsequent correspondence to Clinical Radiology the authors have stated that that they now have 24-36 months of follow-up data with no recorded interval (missed) colonic cancers2.
The additional benefit of CTC compared to colonoscopy is the ability for extra-colonic assessment. Incidental extra-colonic findings were found in 484 (27%) patients; 122 were defined as being incompletely characterised and needing further radiological investigation and 214 defined as a significant or potentially significant incidental findings. Extra-colonic cancer was identified in 4.3% of patients in 20 different locations with renal and gastric carcinoma being most common.
The article also addresses a number of the perceived issues surrounding the use of CTC. This includes the potential harm associated with ionising radiation and additional costs of further investigation following CTC. However, in this study the calculated harm from radiation doses have been shown to be at levels considered ‘too small to be observed or inexistent” by the Health Physics Society in this group of patients. They have also estimated that the introduction of a CTC led pathway has resulted in local cost-savings of at least £500,000 annually, even when subsequent endoscopic assessment and the further investigation of incidental findings are factored in. In addition, national targets (for referral to test within 14 days) were achieved in 95%, which the authors describe as a significant improvement on the prior colonoscopy led service.
The main limitation of the study was the relatively short follow-up period, but the subsequent correspondence from the authors showed no interval (missed) cancers between 24-36 months. However, it is reasonable to assume that in a symptomatic population, any missed symptomatic CRC’s would be identified within 2 years from initial presentation.
The authors should be commended for their work in developing such a substantial service. This study highlights that a CTC led symptomatic service in a single centre can achieve comparable performance data to that of a large multicentre trial like SIGGAR, while also balancing common arguments against CTC including the perceived radiation risk and additional costs, with the benefit of assessing for extra-colonic pathology. CTC is a viable, cost saving and pragmatic alternative to colonoscopy in this cohort of symptomatic patients at a time when endoscopy services are overwhelmed and cancer related targets are becoming increasingly difficult to achieve.
1. Atkin, W., Dadswell, E., Wooldrage, K. et al. Computed tomographic colonography versus colonoscopy for investigation of patients with symptoms suggestive of colorectal cancer (SIGGAR): a multicentre randomized trial. Lancet. 2013; 381: 1194–1202
2. RE: Straight-to-test faecal tagging CT colonography for exclusion of colon cancer in symptomatic patients under the English 2-week-wait cancer investigation pathway: a service review. A reply. Stephenson, J.A. et al. Clinical Radiology, Volume 74, Issue 8, 644
Dr. Adam Laverty is a radiology trainee heading into his fifth and final year on the West Yorkshire radiology training scheme. He is currently based at St. James University Hospital (Leeds/UK) where he is undertaking speciality training in GI/HPB imaging and non-vascular intervention.
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Error and discrepancy in radiology: inevitable or avoidable?
Brady AP. Insights Imaging. 2017 Feb;8(1):171-182. doi: 10.1007/s13244-016-0534-1. Epub 2016 Dec 7. Review. PubMed PMID: 27928712; PubMed Central PMCID: PMC5265198.
Dr. Damian Tolan
ESGAR Fellow and Clinical Lead for CT and GI/HPB imaging, St James’s University Hospital, Leeds Teaching Hospitals, Leeds, UK.
Over the last few years the ESGAR Journal watch articles have highlighted scientific observations related to organ specific assessment with CT, MRI and ultrasound in liver, pancreatic and gastrointestinal diseases. Perhaps we have neglected the most important organ of all, and the one that we rely upon the most: the radiologist’s brain! How do we interact with patient imaging? How does variance occur in interpretation and how does underperformance arise? How do we cope with error and discrepancy when assessing scans?
In an era when psychology and performance analysis is increasingly recognised as critical in high level sport and aviation, this paper successfully leads us through the subject with a radiology focus. Irish Radiologist Dr. Adrian Brady provides a superb structured appraisal of a complex area, and one that many radiologists have not been taught during training. It is more important than ever that we have a thorough personal understanding of the human factors that influence us when we face an ever-increasing reporting workload. This is essential when we personally reflect on cases that have not achieved the desired outcome for our patients, so that we a can effectively learn lessons to openly share with our colleagues.
After defining what error, discrepancy, negligence and hindsight bias mean, the ‘distribution’ of radiologist performance is discussed and how prevalent error is, not only in radiology practice but in other medical specialities.
While we all recognise that errors can occur as a consequence of poor communication in our reporting, compounded by transcription errors in voice recognition, visual fatigue, decision fatigue and inattentional blindness while viewing images all contribute to suboptimal performance. This is further compounded by a series of cognitive biases that lead us to make the wrong conclusion when the available information is presented to us that might allow us to make the right diagnosis.
A series of strategies are provided that may be considered to minimize error, including departmental Quality Improvement programmes to share learning from cases, performing root cause analysis to assess the cause for discrepancies and to encourage openness and shared learning by educating both senior radiologists and trainees by avoiding a blame culture.
If you only read one full journal article this year then read this one – it is open access so there is no reason not to! Take time to reflect on it and to really understand how we each fail from time to time (and every one of us does, without exception). We all need a thorough education in these human factors in advance of Artificial (or Augmented) Intelligence being introduced to our personal practice if we are going to translate the potential benefits of this technology into improved diagnostic performance for our patients.
Dr. Damian Tolan is a gastrointestinal radiologist from St James’s University Hospital (Leeds, UK) specialising in luminal gastrointestinal imaging with a particular clinical and research interest in colorectal cancer, inflammatory bowel disease and perianal disease. He co-chaired the ‘One case - three lessons’ session at the ESGAR Annual Meetings in 2018 and 2019.
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MRI assessment of hepatocellular carcinoma after locoregional therapy
Rasha S. Hussein, Wahid Tantawy and Yasser A. Abbas
Journal: Insights into Imaging 2019 Jan 29;10(1):8. doi: 10.1186/s13244-019-0690-1
Dra. Asunción Torregrosa Andrés, ESGAR fellow and Head of the Abdominal Radiology Section and Dr. Alberto Alegre-Delgado, ESGAR Member and Radiology Resident in his fourth and last year of training, both working in Hospital La Fe, Valencia (Spain).
Hepatocellular carcinoma is well-known to be the most frequent primary malignant tumor of the liver, usually in the setting of liver cirrhosis, and an important cause of morbidity and mortality worldwide (1,2). There has been in the last decades an important development of locoregional therapies for the HCC with curative, downstaging or palliative aim. In this article, the Egyptian team of Hussein et al made a bibliographic review to illustrate the current state-of-the-art MRI techniques and imaging appearances in the evaluation of tumor response based on LI-RADS v2018 and mRECIST criteria.
There are several therapeutic options depending on size, location of the tumor, and clinical state of the patient (3). Locoregional therapies include 1) thermal ablation (either radiofrequency or microwave ablation) with curative intention, usually prefered in early-HCC stages with high response rates; 2) transarterial chemoembolization (TACE) with PVA spheres loaded with doxorubicin (QT) in combination with lipiodol, which may be applied in order to understage the tumor and making it a candidate for a curative technique, so this technique is preferred in intermediate stages; and, finally, 3) transarterial radioembolization (TARE) by means of ytrium-loaded microspheres (Y90) that exert local effect.
In response evaluation criteria, it is important to take into account vascularization and tumor necrosis apart from the size of the lesion itself, which may not vary or even increase, as several articles in the literature corroborate Kielar et al (3). Based on the limitation of the one-dimensional measurement required by the RECIST, the EASL-mRECIST system uses the largest diameter of the hyperenhanced portion of the lesion as a residual viable tumor emerged. In addition, the LI-RADS algorithm for treated lesions (LR-TR) includes the variability of the image before applying the mRECIST, so the response to treatment may be 1) non-evaluable, if the image quality is suboptimal; 2) non-viable, if there is no suggestive enhancement of residual viable tumor; 3) viable, if nodular enhancement persists and 4) equivocal, if doubts are present.
Locorregional treatments lead to inflammatory changes in the surrounding parenchyma (hyperemia and edema) that may represent a challenge for the radiologist in differentiating normal post-treatment changes and residual viable tumor. Multiparametric MRI imaging including diffusion- and perfusion-weighted imagens may help to discriminate between both conditions (4).
In dinamic contrast-enhanced MRI, linear and transitory surrounding enhancement is usually seen in post-treatment inflammatory changes, while a gross, heterogeneous and nodular enhancement indicates residual tumor. Subtraction sequences may help differentiate real hyperenhancement from T1 bright components like post-treatment hemorrhagic debris. Analysis of contrast kinetics may also be helpful to depict residual tumor as some articles have showed HCC tissue to lower mean transit time and a higher volume of distribution (4).
Restriction in DWI with high b-values (800-1000) is a reliable indicator of cellularity and the ADC value can be used as an image biomarker of tumor response. Several studies have correlated higher ADC values with good tumor response in 6 months after treatment applying mRECIST criteria and also with a longer disease-free survival. The value of ADC is currently being investigated as an imaging biomarker in order to predict tumor response before the HCC is even treated, so that lesions with low pretreatment ADC values may respond better due to its high rate of cellularity and vascularization (5).
The intravoxel incoherent motion (IVIM) MR technique is highlighted in this article review. This technique is able to study diffusion and perfusion without the need to introduce contrast (6). It distinguishes the pure diffusion attributable to cellularity, and pseudodiffusion attributable to microvascularization, so IVIM can substract the value of vascularization (D*) and provide a more reliable diffusion coefficient (D), which reflects directly the cellularity of the lesion. IVIM is a promising imaging biomarker to early detect local recurrence or viable residual tumor.
This article is of great interest for every abdominal radiologist who has to assess HCC tumor response on MRI, since it provides the basis for a common reporting language (LI-RADS and EASL-mRECIST criteria), usual imaging appearances, as well as a global view of established MRI techniques and promising biomarkers for the evaluation of HCC response to locoregional therapies.
1. McEvoy SH, McCarthy CJ, Lavelle LP, Moran DE, Cantwell CP, Skehan SJ, et al. Hepatocellular Carcinoma: Illustrated Guide to Systematic Radiologic Diagnosis and Staging According to Guidelines of the American Association for the Study of Liver Diseases. RadioGraphics. October 2013;33(6):1653-68.
2. Yaghmai V, Besa C, Kim E, Gatlin JL, Siddiqui NA, Taouli B. Imaging Assessment of Hepatocellular Carcinoma Response to Locoregional and Systemic Therapy. Am J Roentgenol. July 2013;201(1):80-96.
3. Kielar A, Fowler KJ, Lewis S, Yaghmai V, Miller FH, Yarmohammadi H, et al. Locoregional therapies for hepatocellular carcinoma and the new LI-RADS treatment response algorithm. Abdom Radiol. January 2018;43(1):218-30.
4. Taouli B, Johnson RS, Hajdu CH, Oei MTH, Merad M, Yee H, et al. Hepatocellular Carcinoma: Perfusion Quantification With Dynamic Contrast-Enhanced MRI. Am J Roentgenol. October 2013;201(4):795-800.
5. Mannelli L, Kim S, Hajdu CH, Babb JS, Clark TWI, Taouli B. Assessment of Tumor Necrosis of Hepatocellular Carcinoma After Chemoembolization: Diffusion-Weighted and Contrast-Enhanced MRI With Histopathologic Correlation of the Explanted Liver. Am J Roentgenol. October 2009;193(4):1044-52.
6. Kakite S, Dyvorne HA, Lee KM, Jajamovich GH, Knight-Greenfield A, Taouli B. Hepatocellular carcinoma: IVIM diffusion quantification for prediction of tumor necrosis compared to enhancement ratios. Eur J Radiol Open. 2016;3:1-7.
Dr. Alberto Alegre Delgado is a radiologist in his fourth and last year of training and is currently working at University and Polytechnic La Fe Hospital in Valencia (Spain). Since the beginning of his training, he has been interested in abdominal radiology and worked extensively in this area. He is an active ESGAR member and attended various ESGAR biomarkers workshops and events such as the Junior ESGAR Summer School in Portugal in 2018. During his residency, he also specifically collaborated in multidisciplinary investigation projects with hepatic surgeons including pre- and postoperative liver volumetry in patients with liver metastases, and in other hepatic segmentation projects with QuiBimÓ biomarkers group.
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Radiomic Analysis of Contrast-Enhanced CT Predicts Microvascular Invasion and Outcome in Hepatocellular Carcinoma
Xun Xu, Hai-Long Zhang, Qiu-Ping Liu, Shu-Wen Sun, Jing Zhang, Fei-Peng Zhu, Guang Yang, Xu Yan, Yu-Dong Zhang, Xi-Sheng Liu
Reference: JHEPAT 7291
To appear in: Journal of Hepatology
Recurrence after curative treatment for hepatocellular carcinoma (HCC) (surgery, percutaneous thermal ablation or liver transplantation) is up to 70% within 5 years after surgical resection or thermal ablation, and 35% after liver transplantation 1–3. Macro and micro-vascular invasion are both prognosis factor of recurrence 4–6, but at odd to macrovascular invasion that can be detected by cross-sectional imaging, micro-vascular invasion (MVI) is a histological finding that can only be post operatively diagnosed with surgical specimen 7. Several biological, genetic and imaging factors have showed association with MVI. More recently radiomics showed promising results 3,8,9. Radiomics is a newly emerging form of imaging analysis using a series of datamining algorithms or statistical analysis tools on high-throughput imaging features to obtain predictive or prognostic information. However these parameters are not widely used in practice. Therefore the aim of this study was to to investigate whether a computational approach integrating large-scale clinical and imaging modalities, especially radiomic features extracted from contrast-enhanced CT (CECT), could be useful to predict MVI and the long-term clinical outcomes of HCC patients.
In their retrospective study, Xun Xu et al included 495 cases from liver specimen (after surgery or liver transplantation). Routine preoperative laboratory examinations before liver surgery were performed and CECT according to AASLD guidelines was used to radiomics analysis. Radiomics was performed on the entire tumor volume and in a region at a 5mm distance from tumor surface(because MVI is around the tumor). A model was computed on a training group (n=300), and then validated on a validation group (n=50) and a testing group (n=145).
In the multivariate regression model, 8 predictors were independent prognostic factors of histologic MVI: higher AST (> 40 U/L), higher AFP (> 400ng/mL), non-smooth tumor margin, extrahepatic growth pattern, ill-defined pseudocapsule, peritumoral arterial enhancement, positive of radio-genomic venous invasion score-8-, and higher Radiomics-score. A risk model integrating clinicoradiologic factors and Rariomics-scores can identify more than 88% of the MVI-positive cases with a specificity of 76.8%-79.2%. The median PFS was 12.9 (7.1-25.5) months for patients with Model-predicted MVI presence and 49.5 (42.3-93.7) months for those with Model-predicted MVI absence (log-rank test, p < 0.001). The median OS was 47.3 (40.6–54.1) months for those with Model-predicted MVI presence and 76.3 (71.6–80.8) months for those with Model -predicted MVI absence (log-rank test, p < 0.001).
So Xun Xu et al found that combining biological, genomic, imaging features and radiomics analysis offered a viable solution to predict MVI for HCC. However these results need to be confirmed in a different population. Indeed this study was performed in china where the main cause of HCC is hepatitis B without cirrhosis. In Europe HCC occurred mainly on non-viral cirrhosis, therefore we can assume this could lead to different results due to the heterogeneity of a liver parenchyma in case of cirrhosis and to the different oncologic pathway between HCC occurring on hepatitis B compared to non-viral cirrhosis. Nevertheless radiomics is a promising and emerging tool in the radiological and oncological field.
1. Hepatocellular carcinoma recurrence and death following living and deceased donor liver transplantation. - PubMed - NCBI. Available at: www.ncbi.nlm.nih.gov/pubmed/17511683. (Accessed: 26th March 2019)
2. Marshall, A. E. et al. Tumor recurrence following liver transplantation for hepatocellular carcinoma: role of tumor proliferation status. Liver Transplant. Off. Publ. Am. Assoc. Study Liver Dis. Int. Liver Transplant. Soc.16, 279–288 (2010).
3. Banerjee, S. et al. A computed tomography radiogenomic biomarker predicts microvascular invasion and clinical outcomes in hepatocellular carcinoma. Hepatol. Baltim. Md62, 792–800 (2015).
4. Shah, S. A. et al. Recurrence after liver resection for hepatocellular carcinoma: risk factors, treatment, and outcomes. Surgery141, 330–339 (2007).
5. Nakashima, Y. et al. Portal vein invasion and intrahepatic micrometastasis in small hepatocellular carcinoma by gross type. Hepatol. Res. Off. J. Jpn. Soc. Hepatol.26, 142–147 (2003).
6. D’Amico, F. et al. Predicting recurrence after liver transplantation in patients with hepatocellular carcinoma exceeding the up-to-seven criteria. Liver Transplant. Off. Publ. Am. Assoc. Study Liver Dis. Int. Liver Transplant. Soc.15, 1278–1287 (2009).
7. Rodríguez-Perálvarez, M. et al. A systematic review of microvascular invasion in hepatocellular carcinoma: diagnostic and prognostic variability. Ann. Surg. Oncol.20, 325–339 (2013).
8. Renzulli, M. et al. Can Current Preoperative Imaging Be Used to Detect Microvascular Invasion of Hepatocellular Carcinoma? Radiology279, 432–442 (2016).
9. Lei, Z. et al. Nomogram for Preoperative Estimation of Microvascular Invasion Risk in Hepatitis B Virus-Related Hepatocellular Carcinoma Within the Milan Criteria. JAMA Surg.151, 356–363 (2016).
Dr. Arnaud Hocquelet is a radiologist working in the interventional radiology unit at Vaud University Hospital (Lausanne,Switzerland). Dr Hocquelet's main interest is oncological interventional radiology and he already published several articles about thermal ablation and abdominal imaging.
Comments may be sent to: Arnaud.Hocquelet@remove-this.chuv.ch
Pretreatment prediction of immunoscore in hepatocellular cancer: a radiomics-based clinical model based on Gd-EOB-DTPA-enhanced MRI imaging
Shuling Chen, Shiting Feng, Jingwei Wie, Fei Liu, Bin Li, Xin Li, Yang Hou, Dongsheng Gu, Mimi Tang, Han Xiao, Yingmei Jia, Sui Peng, Jie Tian, Ming Kuang. European Radiology, 2019
Reviewed By Naik Vetti Violi CHUV University hospital Lausanne Switzerland
Systemic immunotherapy is a recent treatment alternative for non-resectable hepatocellular carcinoma (HCC). However, the expected response rate is low, around 20% (1). Patient selection tool is indeed needed to avoid unnecessary costs and side effects. Density of tumor infiltration lymphocytes (TILs) has shown to be associated to immunotherapy response and survival. Immunoscore based on the characteristics of TILs has been described for different cancers including HCC (2, 3). In HCC, high immunoscore has shown to be associated with low recurrence rate and longer progression-free survival (4, 5). However, such a score is based on histologic examination and requires invasive tissue sampling. New imaging tools as radiomics have been proposed as surrogate for histologic examination, avoiding tissue sampling risks and allowing repetitive measurements of the entire tumor volume (6).
Radiomics is based on the concept that images contain information about pathophysiology that can be expressed by the extraction of a large number of quantitative features. Radiomics analysis provides a large amount of data that are not limited to the visual evaluation and can be extracted from the entire tumor volume and at each imaging follow-up in the course of the cancer. Qualitative and quantitative features based on intensity, shape, size, volume or texture can provide information about tumor phenotype and microenvironment that can be correlated to clinical outcomes.
Correlation between immunoscore and radiomics feature has already been shown in lung cancer but not in HCC (7).
In this retrospective single center study performed in China, Dr Chen and colleagues developed a radiomics model for the prediction of immunoscore in HCC. They include patients with histologically proven HCC who underwent hepatectomy between 2011 and 2017 for a single lesion or multiple lesions within the same liver lobe and who underwent MRI using gadoxetic acid within one month before surgery. All the MRIs were performed using the same machine (Siemens Sector 3.0-T) and protocol. Exclusion criteria were any anti-tumor therapies, any concomitant malignancies or incomplete data. The study population consisted of 207 patients.
The immunoscore was already validated and was based on the degree of CD3 and CD8 infiltration in the tumor center and margin (3).
Each lesion was manually delineated on hepatobiliary phase (HBP) in 3D in order to get a volume of interest (VOIs) by three independent experienced radiologists, with good correlation scores. An algorithm that dilated the tumoral region of 1 cm determined the peritumoral region. MR features were extracted and analyzed using a house-made software. A large number of first and second order radiomics features were included in the analysis (1044 imaging features) including histogram features, texture, form factor and grey level parameters. An extremely randomized tree method was used to select the most relevant features. A training set (n=150 patients) was used to build the radiomics model and validation set (n=57 patients) to test it. Different models were tested using either intratumoral region or combined intratumoral with peritumoral regions features. Additionally, the model was tested by combining clinical data to the radiomics features. Included clinical data were AFP, GGT, AST.
The final models consisted of 70 radiomics features. Results showed that the model integrating intra and peritumoral radiomics features with combination of clinical data showed the best prediction performance for immunoscore (validation set: AUC: 93.4%. sensitivity: 84.6%, specificity: 84.1%), despite no statistical difference with the combined intra and peritumoral radiomics model.
This study presents several points of methodology that have to be highlighted. (1) The integration of the peritumoral region is meaningful when considering TILs. Rate of peritumoral lymphocytes infiltration has shown to be associated in HCC recurrence (8). Furthermore, radiomics model integrating peritumoral region has been successfully achieved in breast cancer already (9). Consequently, there is an interest of considering not only the tumor itself but also the liver surrounding the tumor. (2) Integration of clinical data – that improved the model performance - evidenced the complementarity of information and the potential interest of combining radiologic and clinical data in the model. (3) 3D lesion evaluation is interesting as it reflects the entire tumor architecture and heterogeneity. It is one of the main advantages of radiomics analysis compared to biopsy, which only represents a sample with a potential risk of sampling error and inter-observer variations (10, 11). (4) The use of HBP for radiomics extraction is valuable as it has shown to allow higher lesion conspicuity comparing to dynamic phases (12). HBP could be useful to develop software for automatic lesion boundaries drawing in order to avoid manual lesion delineation.
Authors acknowledge some study limitations that are classical limitations inherent to radiomics analysis: the limited population size compared to the large number of integrated features, the absence of external validation set and the correlation only with TILs, not integrating other predictor of immunotherapy response. Additional limitations have to be highlighted: the manual segmentation and the use of house-made radiomics software can be cited as limitations for generalization. When looking at the study population, most of the patients presented limited liver disease extension (BCLC A in 52.2%) and small tumor size (<5cm in 59.4%) which typically not represent the target population for immunotherapy. A validation with more advanced HCC is indeed needed.
Systemic immunotherapy seems to be a promising future direction for HCC treatment, in particular when considering advanced stages. Due to its high cost and low rate of tumor response, an accurate patient selection tool is needed. This study showed the feasibility of developing a radiomics-based model as a surrogate to immunoscore that could be used for patient selection based on imaging avoiding the need for tissue sample. However, this study also showed the missing steps that have to be overpassed in order to be a clinical practice tool: the need for software harmonization, external validation and accurate automated software for lesion delineation. Further investigations in order to transfer these promising results to clinical practice are needed, particularly by correlating the present results with patient outcomes (rate of tumor response, progression free survival, overall survival for instance) in order to validate them.
1. El-Khoueiry AB, Sangro B, Yau T, Crocenzi TS, Kudo M, Hsu C, Kim TY, et al. Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial. Lancet 2017;389:2492-2502.
2. Brunner SM, Rubner C, Kesselring R, Martin M, Griesshammer E, Ruemmele P, Stempfl T, et al. Tumor-infiltrating, interleukin-33-producing effector-memory CD8(+) T cells in resected hepatocellular carcinoma prolong patient survival. Hepatology 2015;61:1957-1967.
3. Galon J, Mlecnik B, Bindea G, Angell HK, Berger A, Lagorce C, Lugli A, et al. Towards the introduction of the 'Immunoscore' in the classification of malignant tumours. J Pathol 2014;232:199-209.
4. Garnelo M, Tan A, Her Z, Yeong J, Lim CJ, Chen J, Lim KH, et al. Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma. Gut 2017;66:342-351.
5. Yao Q, Bao X, Xue R, Liu H, Liu H, Li J, Dong J, et al. Prognostic value of immunoscore to identify mortality outcomes in adults with HBV-related primary hepatocellular carcinoma. Medicine (Baltimore) 2017;96:e6735.
6. Jeong WK, Jamshidi N, Felker ER, Raman SS, Lu DS. Radiomics and radiogenomics of primary liver cancers. Clin Mol Hepatol 2018.
7. Tang C, Hobbs B, Amer A, Li X, Behrens C, Canales JR, Cuentas EP, et al. Development of an Immune-Pathology Informed Radiomics Model for Non-Small Cell Lung Cancer. Sci Rep 2018;8:1922.
8. Cai XY, Wang JX, Yi Y, He HW, Ni XC, Zhou J, Cheng YF, et al. Low counts of gammadelta T cells in peritumoral liver tissue are related to more frequent recurrence in patients with hepatocellular carcinoma after curative resection. Asian Pac J Cancer Prev 2014;15:775-780.
9. Braman NM, Etesami M, Prasanna P, Dubchuk C, Gilmore H, Tiwari P, Plecha D, et al. Intratumoral and peritumoral radiomics for the pretreatment prediction of pathological complete response to neoadjuvant chemotherapy based on breast DCE-MRI. Breast Cancer Res 2017;19:57.
10. Clauson J, Hsieh YC, Acharya S, Rademaker AW, Morrow M. Results of the Lynn Sage Second-Opinion Program for local therapy in patients with breast carcinoma. Changes in management and determinants of where care is delivered. Cancer 2002;94:889-894.
11. Robert M, Sofair AN, Thomas A, Bell B, Bialek S, Corless C, Van Ness G, et al. A comparison of hepatopathologists' and community pathologists' review of liver biopsy specimens from patients with hepatitis C. Clin Gastroenterol Hepatol 2009;7:335-338.
12. Besa C, Kakite S, Cooper N, Facciuto M, Taouli B. Comparison of gadoxetic acid and gadopentetate dimeglumine-enhanced MRI for HCC detection: prospective crossover study at 3 T. Acta Radiol Open 2015;4:2047981614561285.
Dr. Naik Vietti Violi is a radiologist at Mount Sinai Hospital (New York, USA) where she is working as a research fellow. She completed her residency at Lausanne University Hospital (CHUV, Lausanne, Switzerland) where she will come back after her fellowship. She specialized in oncology and abdominal imaging. Her main research projects include inflammatory bowel diseases, tumor response after loco-regional therapy in liver and more recently abbreviated MRI for hepatocellular cancer detection.
Comments may be sent to: firstname.lastname@example.org
Prospective Intraindividual Comparison of Magnetic Resonance Imaging With Gadoxetic Acid and Extracellular Contrast for Diagnosis of Hepatocellular Carcinomas Using the Liver Imaging Reporting and Data System.
Min JH, Kim JM, Kim YK, Kang TW, Lee SJ, Choi GS, Choi SY, Ahn S.
Journal: Hepatology. 2018; 68(6):2254-2266.
Mariangela Dimarco (radiology resident, University of Palermo, Palermo/IT)
Federica Vernuccio (radiologist and PhD student, University of Palermo, Palermo/IT)
Hepatocellular carcinoma (HCC) is the most common primary hepatic malignant tumor worldwide. The diagnosis of HCC is oftentimes made non invasively on CT or MR imaging, thus reducing the need for biopsy. In their study, Min et al performed an intraindividual prospective comparison of the diagnostic accuracy of extracellular contrast enhanced MRI and hepatobiliary contrast enhanced MRI for the diagnosis of HCC. The study population included 91 patients at risk for HCC with a suspicious focal liver lesion detected on US and indicated for surgery between November 2016 and November 2017. Prior to surgery, each patient performed an extracellular contrast enhanced MRI and a hepatobiliary contrast enhanced MRI. MRI images were reviewed by two expert radiologists and lesions were categorized according to LI-RADS. The comparison of sensitivity, specificity and diagnostic accuracy of the two contrast agents resulted in a significantly higher sensitivity and diagnostic accuracy for the diagnosis of HCC with the extracellular contrast agent (77.9% and 82.1%, respectively) compared to the hepatobiliary one (66.3% and 72.6%, respectively), while specificity was 100% for both contrast agents. The values of sensitivity in this prospective study are equal or slightly lower than those reported by Roberts et al in a recent metanalysis (i.e. 75% and 87% for extracellular contrast enhanced MRI and hepatobiliary contrast enhanced MRI, respectively). However, this slight reduction in sensitivity in the study by Min et al is associated with a specificity of 100% with both contrast agents, which is higher compared to the results of the metanalysis (86% and 94% for extracellular contrast enhanced MRI and hepatobiliary contrast enhanced MRI, respectively).
Min et al evaluated also the diagnostic role of a "modified" washout – i.e. relative hypointensity in portal venous or transitional phases using hepatobiliary agent or isointensity with capsule on the portal venous or delayed phases using extracellular contrast agent (i.e., illusional washout) – for the diagnosis of HCC. According to the results, the "modified" washout was associated with greater diagnostic performance compared to conventional washout (as defined by LI-RADS). Of 95 HCC confirmed at pathology, 87 (91.6%) showed a “modified” washout while only 76 (80%) and 74 (78%) lesions showed a conventional washout using an extracellular or a hepatobiliary agent, respectively. The analysis of the diagnostic performance of a "modified" version of LI-RADS with the adoption of the "modified" washout as a major criterion for the diagnosis of HCC resulted in a greater sensitivity and accuracy using the extracellular contrast agent (89.5% and 91.5%, respectively) compared to the hepatobiliary one (80% and 83.8%, respectively), with 100% specificity in both cases.
LI-RADS categorization categorized primary and secondary liver malignancies lacking the imaging findings typical for HCC as LR-M. In the study of Min et al, of the 2 intrahepatic cholangiocarcinomas, one was correctly categorized as LR-M with both agents, while one was categorized as LR-M using the hepatobiliary agent because of a target appearance (i.e. central enhancing area with a peripheral hypointense rim) in the transitional phase, but it was categorized as LR-4 using the extracellular contrast agent because it was purely hypointense on the portal venous and delayed phases. In addition, the results of the study by Min et al highlighted the importance of the capsule for the differential diagnosis between HCC and other hepatic tumors. The “enhancing” capsule is considered a major criterion by LI-RADS and AASLD for the diagnosis of HCC while other classification systems (i.e. EASL, APASL) underestimate its importance and do not include this important feature for the diagnosis of HCC. However, while an enhancing capsule was observed in 87% HCCs on extracellular contrast based MRI, only 47% HCCs showed this important feature on hepatobiliary contrast based-MRI.
In conclusion, the prospective study by Min et al emphasizes the increased sensitivity and diagnostic accuracy of the extracellular contrast agent compared to the hepatobiliary one in the final diagnosis of HCC, along with an equal strikingly high specificity (100%). Min et al suggest a modified version of LI-RADS, which includes a “modified” washout as a major imaging features for the diagnosis of HCC due to its high diagnostic performance. In addition to the analysis of the typical vascular behavior of HCC for the diagnosis, the enhancing capsule is of utmost importance for the diagnosis of HCC, since this imaging feature is usually not detected in other hepatic lesions (i.e. dysplastic nodule, cholangiocarcinoma or hemangioma).
1. McGlynn KA, Petrick JL, London WT. Global epidemiology of hepatocellular carcinoma: an emphasis on demographic and regional variability. Clin Liver Dis. 2015;19(2):223-38.
2. https://www.acr.org/-/media/ACR/Files/RADS/LI-RADS/LI-RADS-2018-Core.pdf?la=en Accessed on Jan 17, 2019
3. Min JH, Kim JM, Kim YK, Kang TW, Lee SJ, Choi GS, Choi SY, Ahn S. “Prospective Intraindividual Comparison of Magnetic Resonance Imaging With Gadoxetic Acid and Extracellular Contrast for Diagnosis of Hepatocellular Carcinomas Using the Liver Imaging Reporting and Data System” (2018) Hepatology. 68(6):2254-2266.
4. Marrero JA, Kulik LM, Sirlin CB, et al. Diagnosis, Staging, and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases. Hepatology. 2018;68(2):723-750.
5. Roberts LR, Sirlin CB, Zaiem F, et al. Imaging for the Diagnosis of Hepatocellular Carcinoma: A Systematic Review and Meta-analysis. Hepatology 2018; 67(1):401-421
6. EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma. European Association for the Study of the Liver. Electronic address: email@example.com; European Association for the Study of the Liver. J Hepatol. 2018;69(1):182-236.
7. Omata M, Cheng AL3, Kokudo N, et al Asia-Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update. Hepatol Int. 2017; 11(4):317-370.
Dr. Mariangela Dimarco is a third-year Radiology resident working in the Radiology Department at the University of Palermo (Palermo, Italy), where she graduated as a medical doctor in March 2015. She is a junior ESGAR member and her main interests are clinical radiology and research, especially emergency and abdominal imaging.
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Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation.
Nault JC, Couchy G, Balabaud C, Morcrette G, Caruso S, Blanc JF, Bacq Y, Calderaro J, Paradis V, Ramos J, Scoazec JY, Gnemmi V, Sturm N, Guettier C, Fabre M, Savier E, Chiche L, Labrune P, Selves J, Wendum D, Pilati C, Laurent A, De Muret A, Le Bail B, Rebouissou S, Imbeaud S; GENTHEP Investigators, Bioulac-Sage P, Letouzé E, Zucman-Rossi J.
Journal: Gastroenterology. 2017;152:880-894.e6.
Dr. Roberto Cannella, radiology resident, University of Palermo (Palermo/IT)
Hepatocellular adenomas (HCAs) are uncommon benign liver lesions, most frequently occurring in young women. HCA is not a single and uniform entity, but it may be classified in different subtypes according to a immunohistochemical and molecular classification. In 2006, HCAs have been initially divided in 4 different subtypes, including: 1) HNF1α-mutated (35-40% of all lesions); 2) Inflammatory (40-50%); 3) β-catenin mutated (10%); 4) Unclassified (10%) HCAs [1, 2]. The sub-classification of HCAs has significant clinical implications. Each subtype carries a different risk of complications, with hemorrhage and malignant transformation mostly commonly occurring in patients with inflammatory and β-catenin mutated subtypes, respectively. Surgical resection has been recommended in lesion larger than 5 cm, HCAs arising in males, or presence of β-catenin mutation.
Magnetic resonance imaging (MRI) has demonstrated a high accuracy for the differential diagnosis of HCAs from other indolent hepatic lesions, such as focal nodular hyperplasia (FNH)  and for the noninvasive sub-classification of those four histopathological subtypes . The presence of lesion hypointensity on images obtained during the hepatobiliary phase acquired after the administration of hepatobiliary contrast agent (Gadoxetic acid, Gd-EOB-DTPA) has a pooled sensitivity and specificity of 95% and 92%, respectively, for differentiation of HCA from FNH . Presence of intra-lesional fat, appearing as marked signal drop on out-of-phase images, is associated with the HNF1α-mutated HCAs, while inflammatory HCAs are described as lesions with intense arterial phase hyperenhancement, hyperintensity on T2-weighted images and with possible presence of a characteristic “atoll” sign .
Recently, a new milestone has been reached for the sub-classification of HCA. The study published by Nault et al. aimed to update the molecular classification of HCA . In their study 533 HCAs from 411 patients, collected among 28 centers, were pathologically analyzed. HCAs were largely present in women (85%) with a median age median age of 38 years (range 7-82 years). HCAs were multiple in 45% of the cases and in 12% a liver adenomatosis (i.e. >10 HCAs) was noted. Hepatic steatosis was present in 12% of cases in the non-tumoral liver parenchyma.
Based on molecular analysis, HCAs were classified in 8 different molecular subgroups. Four new subtypes were described, including the Sonic Hedgehog HCA (4% of all HCAs) which were previously considered as unclassified HCAs, two subtypes with different sites of mutation in β-catenin (CTNNB1) located in exon 7/8 (3%) and exon 3 (7%), respectively, and two mixed inflammatory and β-catenin subtypes (figure below, from the article ).
The novel molecular classification and new subtypes were associated with risk factors and complications, including the risk of intralesional hemorrhage and malignant transformation. History of oral contraceptive use was present in 87% of female patients. The cumulative intake of oral contraceptive, estrogens or androgens, as well as obesity, hepatic steatosis, glycogenosis or liver vascular disease were described as risks factors associated with different molecular subtypes.
Intralesional hemorrhage was histologically observed in about half of the tumors (52%). However, symptomatic bleeding was present only in 14% of the lesions and it was significantly associated with the new subtype of Sonic Hedgehog HCA. The new classification aimed also to stratify patients according to the risk of malignant transformation. Particularly, malignant transformation into hepatocellular carcinoma was associated with male gender and presence of CTNNB1 mutation in exon 3.
Despite the recent advances on molecular classification of HCAs, there are still many gaps in knowledge regarding their imaging characteristics that need to be further studied. The imaging appearance of the new Sonic hedgehog subtype has not been described yet. Although rare, this subtype has the highest risk of macroscopic symptomatic bleeding, so its diagnosis and description of imaging characteristics will have significant clinical implications. Moreover, no studies have explored the value MRI features of HCAs according to the new molecular classification. Analysis of such rare tumors will require multicentric studies including large number of lesions to determine the role of MRI for the non-invasive differentiation of HCAs subtypes according to the new molecular classification. Knowledge of the imaging appearance of HCAs needs to be redefined taking into account the new molecular description of HCA.
1. Zucman-Rossi J, Jeannot E, Nhieu JT, Scoazec JY, Guettier C, Rebouissou S, Bacq Y, Leteurtre E, Paradis V, Michalak S, Wendum D, Chiche L, Fabre M, Mellottee L, Laurent C, Partensky C, Castaing D, Zafrani ES, Laurent-Puig P, Balabaud C, Bioulac-Sage P. Genotype-phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC. Hepatology. 2006;43:515-524.
2. Bioulac-Sage P, Rebouissou S, Thomas C, Blanc JF, Saric J, Sa Cunha A, Rullier A, Cubel G, Couchy G, Imbeaud S, Balabaud C, Zucman-Rossi J. Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry. Hepatology. 2007;46:740-748.
3. Grazioli L, Bondioni MP, Haradome H, Motosugi U, Tinti R, Frittoli B, Gambarini S, Donato F, Colagrande S. Hepatocellular adenoma and focal nodular hyperplasia: value of gadoxetic acid-enhanced MR imaging in differential diagnosis. Radiology. 2012;262:520-529.
4. Ba-Ssalamah A, Antunes C, Feier D, Bastati N, Hodge JC, Stift J, Cipriano MA, Wrba F, Trauner M, Herold CJ, Caseiro-Alves F. Morphologic and Molecular Features of Hepatocellular Adenoma with Gadoxetic Acid-enhanced MR Imaging. Radiology. 2015;277:104-113.
5. Guo Y, Li W, Cai W, Zhang Y, Fang Y, Hong G. Diagnostic Value of Gadoxetic Acid-Enhanced MR Imaging to Distinguish HCA and Its Subtype from FNH: A Systematic Review. Int J Med Sci. 2017;14:668-674.
6. Nault JC, Couchy G, Balabaud C, Morcrette G, Caruso S, Blanc JF, Bacq Y, Calderaro J, Paradis V, Ramos J, Scoazec JY, Gnemmi V, Sturm N, Guettier C, Fabre M, Savier E, Chiche L, Labrune P, Selves J, Wendum D, Pilati C, Laurent A, De Muret A, Le Bail B, Rebouissou S, Imbeaud S; GENTHEP Investigators, Bioulac-Sage P, Letouzé E, Zucman-Rossi J. Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation. Gastroenterology. 2017;152:880-894.e6.
Dr. Roberto Cannella is a fifth-year resident at the Radiology Department at the University of Palermo (Palermo, Italy) and an active ESGAR member who is regularly attending the annual meetings. Dr. Cannella spent 17 months as a research scholar at the Abdominal Imaging Division of the University of Pittsburgh Medical Center (UPMC) in Pittsburgh (Pennsylvania, USA). He has been involved in several research studies centered on hepatobiliary topics, and specifically on CT and MR imaging of hepatocellular adenoma.
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Focal Liver Lesions: Computer-aided Diagnosis by Using Contrast-enhanced US Cine Recordings
Ta CN, Kono Y, Eghtedari M, Oh YT, Robbin ML, Barr RG, Kummel AC, Mattrey RF.
Radiology. 2018 Mar;286(3):1062-1071. doi: 10.1148/radiol.2017170365. Epub 2017 Oct 25.
Dr. Nuno Campos, Resident, Department of Medical Imaging, Coimbra Hospital and University Centre, Coimbra (Portugal).
Prof. Dr. Luís Curvo Semedo, Radiology Consultant, Coimbra Hospital and University Centre; Assistant Professor, Faculty of Medicine - University of Coimbra (Portugal).
At autopsy, as many as 52% of noncancer patients have benign hepatic lesions, and liver metastases are found in as many as 36% of patients dying with cancer (1). Contrast enhanced ultrasound (CEUS) has improved the characterization of focal liver lesions (FLL), offering comparable results to those of computed tomography (CT) and magnetic resonance imaging (MRI) when the ultrasound exploration is technically satisfactory (2-5). Despite their known advantages and potential, CEUS is not included as an indicated imaging modality for the diagnosis of hepatocellular carcinoma (HCC) in recent guidelines, based on a study reporting similar contrast-enhancement patterns between HCC and intrahepatic cholangiocarcinoma (6-8). The concept of computer-aided diagnosis (CAD), developed in order to assist radiologists in detecting abnormal lesions and improving the accuracy of their characterization, has been studied and applied on several imaging modalities, with promising results (9-11).
In this multicenter trial, the authors aimed to assess the ability of CAD systems to distinguish benign from malignant FLL compared to the gold-standard (histologic examination), or, when that was not possible, well-accepted criteria at contrast-enhanced CT and/or MRI. Secondary aims of the study were to determine which features had the greatest impact on the CAD classification of FLLs and to compare its performance to that of two observers, one experienced and one inexperienced.
Two CAD systems were developed by the authors, applying artificial neural networks and support vector machine technology, which were then used to classify benign or malignant lesions given 92 independent features (6 in B-mode, 20 enhancement features, and 66 time-intensity curve features).
The results of the study showed that CAD systems can classify benign and malignant FLL in contrast-enhanced US cine recordings with an accuracy comparable to that of an experienced blinded observer (81.1% vs 81.4%) and had better discrimination than the inexperienced reader (81.1% vs 72.0%). Of all the features analyzed by the CAD system, FLL B-mode homogeneity pre-contrast and time-dependent post-contrast enhancement features (most notably the washout features) were the most discriminating.
Also importantly, when CAD classification was in agreement with that of an experienced or inexperienced reader, it increased their global accuracy to nearly 90%, indicating these systems could provide a second opinion to improve the diagnostic confidence and accuracy when classifications agree or to flag ambiguous lesions for additional review and characterization when they disagree.
As stated by their authors, this study as some limitations, one being the relatively small sample size (105 lesions), with a limited number of lesions smaller than 2 cm (20 lesions). One positive feature of this work is that it included a broad number of FLLs (11 types) attempting to classify them as either benign or malignant, while other published reports are usually limited to three to five lesion types (2,3).
In conclusion, this is an easily readable article, not describing computational analysis exhaustively, but rather focusing on the clinical applicability of this emerging technology. Nevertheless, the study was limited by its relatively small sample size, lacking a representative number of the variety of all FLL types, thus potentially hampering the development of better algorithms to differentiate not only benign from malignant lesions, but also to accurately classify and discriminate different malignant lesions. This may be a leading point for future similar studies that will deal with this same challenge.
1. Berland, Lincoln L., et al. “Managing Incidental Findings on Abdominal CT: White Paper of the ACR Incidental Findings Committee.” Journal of the American College of Radiology, vol. 7, no. 10, 2010, pp. 754–773., doi:10.1016/j.jacr.2010.06.013.
2. Bertolotto, M., et al. “Characterization of Unifocal Liver Lesions with Pulse Inversion Harmonic Imaging after Levovist Injection: Preliminary Results.” European Radiology, vol. 10, no. 9, 2000, pp. 1369–1376., doi:10.1007/s003300000497.
3. Brannigan, Margot, et al. “Blood Flow Patterns in Focal Liver Lesions at Microbubble-Enhanced US.” RadioGraphics, vol. 24, no. 4, 2004, pp. 921–935., doi:10.1148/rg.244035158.
4. Strobel, D, et al. “Contrast-Enhanced Ultrasound for the Characterization of Focal Liver Lesions – Diagnostic Accuracy in Clinical Practice (DEGUM Multicenter Trial).” Ultraschall in Der Medizin - European Journal of Ultrasound, vol. 29, no. 05, Jan. 2008, pp. 499–505., doi:10.1055/s-2008-1027806.
5. Tranquart, F., et al. “Role of Contrast-Enhanced Ultrasound in the Blinded Assessment of Focal Liver Lesions in Comparison with MDCT and CEMRI: Results from a Multicentre Clinical Trial.” European Journal of Cancer Supplements, vol. 6, no. 11, 2008, pp. 9–15., doi:10.1016/j.ejcsup.2008.06.003.
6. Vilana, Ramón, et al. “Intrahepatic Peripheral Cholangiocarcinoma in Cirrhosis Patients May Display a Vascular Pattern Similar to Hepatocellular Carcinoma on Contrast-Enhanced Ultrasound.” Hepatology, vol. 51, no. 6, 2010, pp. 2020–2029., doi:10.1002/hep.23600.
7. Claudon, M., et al. “Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) in the Liver – Update 2012.” Ultraschall in Der Medizin - European Journal of Ultrasound, vol. 34, no. 01, May 2012, pp. 11–29., doi:10.1055/s-0032-1325499.
8. “EASL–EORTC Clinical Practice Guidelines: Management of Hepatocellular Carcinoma.” Journal of Hepatology, vol. 56, no. 4, 2012, pp. 908–943., doi:10.1016/j.jhep.2011.12.001.
9. Doi, Kunio. “Computer-Aided Diagnosis in Medical Imaging: Historical Review, Current Status and Future Potential.” Computerized Medical Imaging and Graphics, vol. 31, no. 4-5, 2007, pp. 198–211., doi:10.1016/j.compmedimag.2007.02.002.
10. Gatos, Ilias, et al. “A New Automated Quantification Algorithm for the Detection and Evaluation of Focal Liver Lesions with Contrast-Enhanced Ultrasound.” Medical Physics, vol. 42, no. 7, Oct. 2015, pp. 3948–3959., doi:10.1118/1.4921753.
11. Shiraishi, Junji, et al. “Computer-Aided Diagnosis for the Classification of Focal Liver Lesions by Use of Contrast-Enhanced Ultrasonography.” Medical Physics, vol. 35, no. 5, Oct. 2008, pp. 1734–1746., doi:10.1118/1.2900109.
Dr. Nuno Campos is a second-year resident at Coimbra Hospital and University Centre in Portugal. He completed his undergraduate medical degree at University of Minho in 2016. His main interests are abdominal and musculoskeletal diagnostic radiology.
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Non-invasive measurement of liver iron concentration using 3-Tesla magnetic resonance imaging: validation against biopsy
Gaspard d’Assignies, Anita Paisant, Edouard Bardou-Jacquet, Anne Boulic, Elise Bannier, Fabrice Lainé, Martine Ropert, Jeff Morcet, Hervé Saint-Jalmes, Yves Gandon.
Eur Radiol. 2017 Nov 24. doi: 10.1007/s00330-017-5106-3.
Dr. Lara Sammut, Higher Specialist Trainee, Mater Dei Hospital, Msida/MT
Dr. Kelvin Cortis, Consultant Radiologist, Mater Dei Hospital, Msida/MT
Liver iron overload is the histological hallmark of hereditary hemochromatosis, transfusional hemosiderosis, as well as certain acquired liver diseases such as non-alcoholic steatohepatitis (NASH) and dysmetabolic iron overload syndrome (DIOS). Excess accumulation of iron in the liver is toxic, and can lead to complications such as cirrhosis and hepatocellular carcinoma. The liver iron content (LIC) (mg Fe/g dry tissue) correlates strongly with total body iron, thus LIC can be used as a surrogate biomarker of body iron stores [1,2].
MRI and genetic testing has drastically reduced the need for iron quantification through liver biopsy , which is both invasive and prone to sampling bias. The two main LIC MRI quantification methods are the signal- intensity- ratio (SIR) and the relaxometry (R2*) method. The SIR method has certain drawbacks, including failure to account for fat effects and tendency to overestimate LIC. This is not the case for the R2* method, which is based on the calculation of T2/R2 or T2*/R2* from signal decay at various echo times.
The aim of the study carried out by d’Assignies et al. was to evaluate the ability of the R2* method at 3T field strength to detect and quantify liver iron, using liver biopsy with biochemical LIC results as a reference method. The authors also compared both SIR and R2* methods at the 3T field strength.
A total of 105 patients who underwent a liver biopsy with estimation of biochemical LIC (LICb) were included prospectively in this study. The LICb concentration ranged from 0 to 630 μmol/g, and 49 patients (47%) had normal LICb values (less than 36 μmol/g). 56 patients had liver iron overload, this was due to genetic haemochromatosis in 31 patients, dysmetabolic syndrome in 22 patients and to other causes (alcoholic or viral hepatitis) in 3 patients.
All of the patients underwent a breath-hold 3T multiple-echo gradient-echo sequence (mGRE) using a body coil and the LIC was calculated using both the SIR (LICSIR) and the R2* (LICR2*) algorithm respectively. Results were correlated with LICb from liver biopsies.
Results showed a strong positive correlation between LICb with both LICR2* (r = 0.95, p < 0.001) and LICSIR (r = 0.92, p < 0.001) methods.
In comparison to LICb, LICR2* and LICSIR were found to detect liver iron overload with a sensitivity/specificity of 96%/93% and 92%/95% respectively. LICR2* presented the lowest differences for patients with LICb values under 130 μmol/g. Above this value, LICSIR was found to have the lowest differences. The authors thus suggest using relaxometry for iron overload below 130 μmol/g and SIR for values above 130 μmol/g because of its better correlation with LIC.
The authors state that the R2* calculation is well-established at 1.5T, however no such validation with biopsies has been done before with at 3T, making the study highly practical since a significant proportion of new MRI scanners use a 3T field strength.
Dedicated DICOM freeware and detailed sequence parameters for scanners from different manufacturers are available on their website www.mrquantif.org. This software uses both methods jointly and selects the best one, and outputs reports and curves that can be imported in the hospital PACS system.
1. Hernando D, Levin YS, Sirlin CB, Reeder SB. Quantification of Liver Iron with MRI: State of the Art and Remaining Challenges. J Magn Reson Imaging 2014; 40(5): 1003–1021.
2. Blachier M, Leleu H, Peck-Radosavljevic M et al. The burden of liver disease in Europe: a review of available epidemiological data. J Hepatol 2013; 58:593–608
3. Brissot P, Troadec MB, Bardou-Jacquet E et al. Current approach to hemochromatosis. Blood Rev. 2008;22(4):195-210.
Dr. Lara Sammut is a fourth-year radiology resident at Mater Dei Hospital, Malta. An active member of ESGAR, she regularly attends workshops organized by the society as well as had the opportunity to present scientific studies at the society’s annual meetings, amongst others. She completed her undergraduate medical degree at the University of Malta in 2011. Her main interests are breast and diagnostic abdominal radiology. She aspires to take part in research studies abroad in the near future.
Comments are to be sent directly to Dr. Cortis or Dr. Sammut.
Long-term Risk of Pancreatic Malignancy in Patients With Branch Duct Intraductal Papillary Mucinous Neoplasm in a Referral Center
Ilaria Pergolini, Klaus Sahora, Cristina R. Ferrone, Vicente Morales-Oyarvide, Brian M. Wolpin, Lorelei A. Mucci, William R. Brugge, Mari Mino-Kenudson, Manuel Patino, Dushyant V. Sahani, Andrew L. Warshaw, Keith D. Lillemoe, and Carlos Fernández-del Castillo. Gastroenterology 2017;153:1284-1294.
Dr. Clarisse Dromain and Dr. Rafael Duran – Centre Hospitalier Universitaire Vaudois (CHUV), Department of Radiodiagnostic and Interventional Radiology, Lausanne, Switzerland.
Intraductal papillary mucinous neoplasm (IPMN) can be classified into three types: branch duct IPMN (BD-IPMN), main duct IPMN and mixed type. Because of their increased likelihood to develop malignancy and/or symptoms, main duct and mixed-type IPMNs more often undergo surgical therapy (1). The management of BD-IPMN is more challenging and long-term outcomes are uncertain with limited knowledge of the natural evolution and malignancy potential of pancreatic cysts beyond 5 years (2).
In the study by Pergolini et al, long-term outcomes of a large cohort of patients undergoing primary surveillance for BD-IPMN were evaluated to determine the risk of pancreatic cancer development after 5 years of follow-up (2). In addition, the authors sought to identify whether any subset of low-risk BD-IPMNs can safely forego surveillance after 5 years of follow-up.
This is a retrospective study in which consecutive patients with a clinical diagnosis of BD-IPMN followed and treated at the Massachusetts General Hospital with a minimum of 6 months of follow-up were included. Patients had at least one cross-sectional imaging (CT, MRI and/or endoscopic ultrasound) done 3 months or longer after the initial diagnosis. Diagnosis of BD-IPMN was based on the presence of unilocular or multilocular cysts of the pancreas and a non-dilated main pancreatic duct (MPD) (<5 mm). All patients with a dilation of the MPD > 5 mm or with cysts suspicious for another diagnosis rather than BD-IPMN (e.g., serous cystadenoma, mucinous cystic neoplasm, pseudocyst) or prior diagnosis of pancreatic cancer were excluded. Imaging and medical charts were reviewed. Patients were classified at the initial diagnosis as having “suspected BD-IPMN” when communication between the cyst and the MPD was documented or when cysts were multifocal or had a cyst fluid carcinoembryonic antigen >192 ng/mL. All remaining cysts were classified as “presumed BD-IPMN” (3). Charts of patients were reviewed for high-risk stigmata (HRS) and worrisome features (WFs). HRS were defined by the presence of obstructive jaundice in a patient with cystic lesion of the head of the pancreas, MPD ≥10 mm, enhancing solid component within the cyst, or cytology positive for high-grade dysplasia or adenocarcinoma. WFs were acute pancreatitis, cyst size ≥ 3 cm, thickened/enhancing cyst walls, non-enhancing mural nodules, MPD size of 5-9 mm, abrupt change in caliber of the MPD and lymphadenopathy (1).
577 patients with suspected or presumed BD-IPMN were included. Median follow-up for the entire cohort was 82 months (range, 6-329 months). 363 patients (63%) underwent surveillance for > 5 years, and 121 (21%) were followed for > 10 years. At diagnosis, a majority of the patients were asymptomatic (n=479, 83%) and of these, 48 (10%) developed symptoms during follow-up. Median cyst size at diagnosis was 14 mm (range 2-54 mm) and 53 patients (9%) had a cyst ≥3 cm. During follow-up, an additional 76 patients developed a lesion >3cm and the median cyst diameter had increased to 20 mm (range, 3-90 mm). At the end of the observational period, 319 patients (55%) had increased cyst size; median increase was 0.9 mm per year of follow-up. Patients who developed malignancy had a significantly larger cyst size at diagnosis compared with those without malignant transformation (19 vs. 14 mm; P =.047), as well as a greater maximum diameter during follow-up (32 vs. 19 mm; P < .001).
Overall, 7.8% of the entire patient population (45/577) developed pancreatic malignancy during the study period; in 36 patients malignancy arose within the pancreatic cyst and 9 patients malignancy arose away from the cyst (distinct or concomitant pancreatic cancer). When looking at the risk of malignancy within 5 years of follow-up, 4.3% (25/577) of the patients developed pancreatic malignancy.
Of the 363 patients followed for > 5 years, malignancy occurred in 5.5% (20/363) and was still present (4.1%) after 10 year follow-up. 22% of patients who were followed for > 5 years had either WFs or HRS by the 5-year time point, and 10% of them developed pancreatic malignancy subsequently. Importantly, the absence of WFs or HRS at a 5-year time point did not exclude the development of malignancy and these patients (n=282) had an 18.8 times higher age-standardized incidence rate of pancreatic malignancy than expected in the general population.
In the analysis, a subgroup of cysts appeared to have a significantly lower risk of development of malignancy. Among the 363 patients followed for > 5 years, 108 (30%) had a cyst that was ≤1.5 cm in size, and only 1 patient in this group (0.9%) developed malignancy. In contrast, 19 patients (7.5%) with cysts >1.5 cm developed malignancy (P=.01). The 1.5-cm cutoff showed a negative predictive value for malignancy of 99% and a sensitivity of 95%.
BD-IPMN is increasingly diagnosed on imaging. The main challenge is to identify which of these BD-IPMNs are susceptible to malignant transformation to define adequate surveillance programs. The overall risk of malignancy in the present study, almost 8%, lasted for 10 years or more for patients with BD-IPMNs. Although it is important to stress that this study cohort, composed of selected patients referred to surgeons and gastroenterologists, may not be representative of the population of incidentally discovered cysts, presented results support continued surveillance after 5 years from the initial diagnosis. This information is relevant because recently published American Gastroenterological Association guidelines recommend stopping surveillance after 5 years (4) while the International Consensus Guidelines 2012 provides recommendations regarding indications for surgical resection and frequency of follow-up on patients managed non-operatively, but does not give an end point to surveillance (1). Pancreatic cysts that remain ≤ 1.5 cm for more than 5 years might be considered low-risk for progression to malignancy.
1. Tanaka M, Fernandez-del Castillo C, Adsay V, Chari S, Falconi M, Jang JY, et al. International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. Pancreatology : official journal of the International Association of Pancreatology. 2012;12(3):183-97.
2. Pergolini I, Sahora K, Ferrone CR, Morales-Oyarvide V, Wolpin BM, Mucci LA, et al. Long-term Risk of Pancreatic Malignancy in Patients With Branch Duct Intraductal Papillary Mucinous Neoplasm in a Referral Center. Gastroenterology. 2017;153(5):1284-94 e1.
3. Mukewar S, de Pretis N, Aryal-Khanal A, Ahmed N, Sah R, Enders F, et al. Fukuoka criteria accurately predict risk for adverse outcomes during follow-up of pancreatic cysts presumed to be intraductal papillary mucinous neoplasms. Gut. 2017;66(10):1811-7.
4. Vege SS, Ziring B, Jain R, Moayyedi P, Clinical Guidelines C, American Gastroenterology A. American gastroenterological association institute guideline on the diagnosis and management of asymptomatic neoplastic pancreatic cysts. Gastroenterology. 2015;148(4):819-22; quize12-3.
Rafael Duran is a junior attending in Radiology specialized in Interventional Radiology, more specifically Interventional Oncology. Dr. Duran works on the development of novel tumor response criteria and imaging biomarkers following locoregional therapies and novel drugs such as agents targeting tumor metabolism or hypoxia. His current main research focuses on liver cancer molecular biology and immnuo-oncology in the setting of image-guided locoregional therapies.
Comments may be sent to Dr. Rafael Duran.
MR imaging of rectal cancer: Radiomics Analysis to Assess Treatment Response after Neoadjuvant Therapy.
Natally Horvat, Harini Veeraraghavan, Monika Khan, Ivana Blazic, Junting Zheng,Marinela Capanu, Evis Sala, Julio Garcia-Aguilar, Marc J. Gollub, Iva Petkovska. Radiology 2018: https://doi.org/10.1148/radiol.2018172300
Dr. Carole Allimant – Centre Hospitalier Universitaire de Montpellier, Department of Radiodiagnostic and Interventional Radiology, Montpellier, France
Dr. Clarisse Dromain – Centre Hospitalier Universitaire Vaudois (CHUV), Department of Radiodiagnostic and Interventional Radiology, Lausanne, Switzerland.
The standard treatment for patients with MR imaging–staged locally advanced rectal cancer (LARC) is neoadjuvant chemotherapy–radiation therapy (CRT) followed by total mesorectal excision. After neoadjuvant CRT, approximately 50% to 60% of patients are downstaged and 15% to 27% show pathologic complete response (pCR)(1).
Selected patients with cCR can be safely treated with CRT (2). However a nonsurgical “watch-and-wait” strategy is not currently supported by the National Comprehensive Cancer Network guidelines (3) and there is an increasing need for evaluation of tumor response.
Radiomics analysis involves computer-based extraction of a large number of quantitative features representing voxel heterogeneity(5) that appears to be an interesting emergent tool for predicting response after CRT (6–8).
This is a retrospective study of patients with LARC who underwent neoadjuvant-CRT followed by surgery at Memorial Sloan Kettering Cancer Center from March 2012 to February 2016. Rectal MR imaging was performed less than 3 months before surgery. Among others, mucinous tumor, recurrent rectal cancer and poor image quality MRI were excluded.
Their final study population consisted of 114 patients. The minimum sequence required was high-spatial-resolution axial oblique T2WI perpendicular to the long axis of the tumor and/or area after treatment, with section thickness of 3 mm. DWI (section thickness of 5mm, 0/800 b-values) was available in only 106 patients.
Two radiologists (5 years and 9 years of experience) reviewed T2WI and DWI, blinded to endoscopic and histopathologic results, to classify the area after treatment as either cCR or cPR in consensus. They had the primary staging MR images at their disposal to guide the delimitation of the tumor bed. For combined assessment, the patient was classified as cCR when cCR was obtained on both T2 or DW images. When combined imaging features at T2WI and DWI were used to diagnose cCR, high sensitivity (84%) and NPV (94%) were achieved; however, it resulted in low specificity (56%) and PPV (30%).
One of the radiologists manually segmented the entire area after treatment, excluding equivocal normal rectal wall and mucosal edema on the T2WI image to provide the volume of interest for texture analysis. Thirty-four texture features consisting of first order (mean, standard deviation, kurtosis, and skewness), second-order Haralick (9) (energy, entropy, correlation, contrast, and homogeneity), Gabor edges at four different orientations and bandwidth (g = 1.4), and second-order texture measures on the Gabor edges were computed.
They used Random Forests (RF) classifier(10) which is a complex model of multiple decision tree–based classifiers of those features. At the end they computed the relative importance of each feature by using the Gini index (10). Second-order texture measures of energy, homogeneity, and contrast were among features that resulted in the largest decrease in the Gini index ie that resulted in the least misclassification (cCR vs pCR). Patients with pCR had significantly higher energy, higher homogeneity, and lower contrast compared with patients with pPR. This indicates that tumors with a homogenous appearance were associated with pCR.
Fourteen of the 34 features were significantly different between pCR and pPR. Their best RF classifier produced high diagnostic performance with an area under the curve of 93% (95%CI: 0.87-0.97) for differentiating pCR from pPR, with a sensitivity of 100% (95% CI: 0.84, 1), specificity of 91% (95%CI: 0.84-0.96), PPV of 72% (95%CI:0.53-0.87),and NPV of 100% (95%CI: 0.96-1).
When compared with the assessment of both T2WI and DWI, radiomics had significantly higher specificity and PPV; however, sensitivity and NPV were not statistically different.
This is an interesting preliminary study showing that radiomic measures can offer better classification performance compared with the qualitative assessment for diagnosing pCR.
They postulate that small clusters of residual tumor cells within the residual area after treatment in pPR may explain the difference in texture in pCR and pPR; however, additional studies with direct correlation to whole-specimen histopathologic analysis are necessary to investigate this further.
Sixty-two (55%) patients were imaged with 1.5-T units, whereas the remaining 52 (45%) were imaged with 3.0-T units. Most computed texture measures showed no significant difference by magnet strength. This was an important finding given the large number of MR imagers available in the market to allow the widespread use of these new imaging techniques.
Although promising and because radiomics classification follows data augmentation it could potentially lead to overoptimistic results, these results require validation on a larger and independent data set to assess the potential for clinical translation.
Moreover, manual segmentation of volume of interest is a time-consuming process; therefore, it is important to develop a user-friendly tool to encourage the use of radiomic measures in daily clinical practice.
1. van de Velde CJH, Boelens PG, Borras JM, Coebergh J-W, Cervantes A, Blomqvist L, et al. EURECCA colorectal: multidisciplinary management: European consensus conference colon & rectum. Eur J Cancer Oxf Engl 1990. 2014 Jan;50(1):1.e1-1.e34.
2. Renehan AG, Malcomson L, Emsley R, Gollins S, Maw A, Myint AS, et al. Watch-and-wait approach versus surgical resection after chemoradiotherapy for patients with rectal cancer (the OnCoRe project): a propensity-score matched cohort analysis. Lancet Oncol. 2016 Feb;17(2):174–83.
3. NCCN Guidelines. National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology. Rectal Cancer version [Internet]. 2017 [cited 2018 Mar 18]. Available from: www.nccn.org/pro- fessionals/physician_gls/pdf/rectal.pdf
4. Patel UB, Brown G, Rutten H, West N, Sebag-Montefiore D, Glynne-Jones R, et al. Comparison of magnetic resonance imaging and histopathological response to chemoradiotherapy in locally advanced rectal cancer. Ann Surg Oncol. 2012 Sep;19(9):2842–52.
5. Nie K, Shi L, Chen Q, Hu X, Jabbour SK, Yue N, et al. Rectal Cancer: Assessment of Neoadjuvant Chemoradiation Outcome based on Radiomics of Multiparametric MRI. Clin Cancer Res Off J Am Assoc Cancer Res. 2016 Nov 1;22(21):5256–64.
6. De Cecco CN, Ciolina M, Caruso D, Rengo M, Ganeshan B, Meinel FG, et al. Performance of diffusion-weighted imaging, perfusion imaging, and texture analysis in predicting tumoral response to neoadjuvant chemoradiotherapy in rectal cancer patients studied with 3T MR: initial experience. Abdom Radiol N Y. 2016 Sep;41(9):1728–35.
7. Cusumano D, Dinapoli N, Boldrini L, Chiloiro G, Gatta R, Masciocchi C, et al. Fractal-based radiomic approach to predict complete pathological response after chemo-radiotherapy in rectal cancer. Radiol Med (Torino). 2018 Apr;123(4):286–95.
8. Liu Z, Zhang X-Y, Shi Y-J, Wang L, Zhu H-T, Tang Z, et al. Radiomics Analysis for Evaluation of Pathological Complete Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer. Clin Cancer Res Off J Am Assoc Cancer Res. 2017 Dec 1;23(23):7253–62.
9. Haralick RM, Shanmugam K, Dinstein IH. Textural features for image classi cation. Trans Syst Man Cybern 1973;SMC- 3(6):610–621. 1973;
10. Breiman L. Random Forests. Mach Learn. 2001 Oct 1;45(1):5–32.
Dr. Carole Allimant works at the Centre Hospitalier Universitaire de Montpellier, more specifcially at the Department of Radiodiagnostic and Interventional Radiology. In 2017, Dr. Allimant finished her residency of which she spent an inter-university exchange of 7 months at the CHUV, Pr Denis, in Lausanne/CH. At this year's ECR, she held an oral presentation on «Tumor targeting and 3D voxel-based dosimetry to predict tumor response, toxicity and survival after Y-90 resin microsphere radioembolization in HCC»
Comments may be sent to Dr. Carole Allimant.
Diagnostic Performance of Magnetic Resonance Imaging and 3D Endoanal Ultrasound in Detection, Staging and Assessment Posttreatment in Anal Cancer
Alfonso Reginelli, Vincenza Granata, Roberta Fusco, Francesco Granata, Daniela Rega, Luca Roberto, Gianluca Pellino, Antonio Rotondo, Francesco Selvaggi, Francesco Izzo, Antonella Petrillo, Roberto Grassi.
Oncotarget. 2017 Apr 4;8(14):22980-22990
Prof. Søren Rafaelsen and Dr. Martina Kastrup Loft – Clinical Cancer Centre, University of Southern Denmark, Department of Radiology, Vejle Hospital, Denmark.
Anal carcinoma is a rare malignancy with an increasing incidence rate in most European countries. Anal cancer includes 2.5% of all gastrointestinal malignancies.
Tumour size in anal cancer is an important measurement in determining the T stage according to the TNM system. With the recent improvements of radiotherapy and chemotherapy as neoadjuvant therapies, however, it is possible to downstage the lesion, this allow for a more conservative treatment.
Diffusion weighted MRI (dw-MRI) quantifies diffusion of water occurring naturally at a cellular level (Brownian movement) which is restricted in multiple neoplasms because of high cellularity. Disruption of cellular integrity secondary to therapy results in increased water diffusion across the injured membranes. Dw-MRI has shown potential to improve the accuracy of therapeutic response prediction in rectal cancer and perhaps in anal cancer.
The objectives of Reginelli´s study were to compare the diagnostic performance of Endoanal Ultrasound (EUS) and dw-MRI including contrast in the detection, staging and assessment of anal cancer patients after therapy (1). The study included 58 patients with biopsy proven anal cancer. A 360° multi-frequency transducer was used in the EUS examination. The MRI scan was performed using a 1.5 Tesla unit and included dw and iv contrast. The EUS and MRI image analysis were performed blindly by experienced observers. All patients had dw-MRI, using MRI 54 of the 58 cancers were detected. The four missed were all T1 tumors. EUS detected all 58 tumors. The patients underwent neoadjuvant treatment. The authors used an ADC (apparent diffusion coefficient) increase of 30% as a definition of response. The tumour ADC increased for responders from 0.830 x 10-6 mm2/s to 1.220x10-6 mm2/s, while non-responders showed no significant difference in ADC value between pre- and posttreatment. The same was true for the lymph nodes. The dynamic MRI contrast enhancement also found a difference between responders and non-responders. The method section is in the final part of the paper.
We performed a systematic literature review of dw-MRI in anal cancer in order to identify more literature on the subject. Embase, and PubMed were searched for full-text articles reporting results from studies of dw-MRI in anal cancer. Articles published before the year 2000, articles written in a language other than English were excluded. The search resulted in the identification of six unique publications. Of these, five were excluded following title and abstract screening. Two studies did not include anal cancer but adenocarcinomas, one paper was a review and one was a case study. Leaving only the study of Reginelli reporting combined MRI and dwi in the staging of anal cancer. However; another very recent an interesting study by Prezzi et al. published in the April issue of European Radiology showed that the maximum tumour diameter and gross tumour volume were significantly lower on dw-MRI than on the T2 w images and dwi yields higher inter-observer agreement (2).
The study of Reginelli, although blinded, has some shortages as the authors did not use disease free survival as an end-point. Further studies are needed to compare the results of the diffusion restriction measurements in anal cancer to the clinical outcome for the patients.
1. Reginelli A, Granata V, Fusco R, Granata F, Rega D, Roberto L, Pellino G, Rotondo A, Selvaggi F, Izzo F, Petrillo A, Grassi R. Diagnostic Performance of Magnetic Resonance Imaging and 3D Endoanal Ultrasound in Detection, staging and Assessment Posttreatment in Anal Cancer. Oncotarget. 2017 Apr 4;8(14):22980-22990
2. Prezzi D, Mandegaran R, Gourtsoyianni S, Owczarczyk K, Gaya A, Glynne-Jones R, Goh V. The impact of MRI Sequence on Tumour Staging and Gross Tumour Volume Delineation in Squamous Cell Carcinoma of the Anal Canal. Eur Radiol. 2018 Apr;28(4):1512-1519
Dr. Martina Loft graduated as a medical doctor from the University of Aarhus in January 2016. During her medical studies she coauthored a paper on percutaneous ultrasound kidney biopsies. She had the opportunity to present her scientific studies at the national society’s annual meeting, amongst others. Martina has a broad range of interests within diagnostic radiology and is working as a first year radiology resident at Vejle Hospital, Clinical Cancer Centre, Denmark.
She aspires to take part in research studies in the near future.
Comments may be sent to Dr. Martina Kastrup Loft.
MRI for Local Staging of Colon Cancer: Can MRI Become the Optimal Staging Modality for Patients With Colon Cancer?
Elias Nerad, Doenja M. J. Lambregts, Erik L. J. Kersten, Monique Maas, Frans C. H. Bakers, Harrie C. M. van den Bosch, Heike I. Grabsch, Regina G. H. Beets-Tan, Max J. Lahaye.
Dis Colon Rectum 2017; 60: 385–392
Prof. Søren Rafaelsen and Dr. Malene Roland Vils Pedersen – Clinical Cancer Centre, University of Southern Denmark, Department of Radiology, Vejle Hospital, Denmark.
Colorectal cancer is the second most common of cancer in developed countries, and is associated with significant morbidity and mortality. Previously the treatment was surgery alone but about half of the resected patients developed incurable recurrent disease. Postoperative chemotherapy can produce a moderate improvement in survival for some patients with stage II and III colorectal cancer, whereas neoadjuvant chemotherapy (NEC) has shown to be effective in rectal cancer and is presumed to have a potential to improve outcome in colon cancer. Multi-detector computed tomography (MDCT) is currently the standard modality for preoperative local staging of colon cancer. MDCT has shown in some studies shown a reasonable accuracy in discriminating between locally and non-locally advanced colon cancer. In rectal cancer, magnetic resonance imaging (MRI) is well established for preoperative local staging and recent studies suggested that MRI may also have an advantage over CT in precise local staging of colon cancer.
In Nerad et al. ´s study the aim was to evaluate the diagnostic performance of MRI for local staging of colon cancer. A total of 55 consecutive patients were diagnosed with colon cancer were included in the study. All patients underwent surgery and histopathological examination. Imaging was performed with a 1.5-tesla MRI unit. The scan protocol consisted of a MR liver protocol combined with an additional MR colon protocol covering the whole abdomen. Two experienced radiologist readers blindly assessed the MR colon images to evaluate the local tumor stage (T1–2 vs T3–4). In case of a T3 or T4 tumor, the depth of extramural invasion (EMD) of ≤5 mm classified as a T3ab tumor and an EMD of >5 mm classified as a T3cd tumor. Adjacent organ invasion was noted as T4. Extramural venous invasion (EMVI); and lymph nodesstatus (N0/N+) were also reported.
The authors found a sensitivity and specificity for detecting T3cd/T4 tumors in patients with a T3 tumor of 40% and 88% for reader 1 and 60% and 75% for reader 2. The sensitivity and specificity for detecting serosal involvement were 88%/74% for reader 1 and 68%/64% for reader 2. Both readers had a high sensitivity of 100% and 88% and a moderate specificity of 62% and 70% in detecting EMVI. The sensitivity and specificity for detecting nodal involvement (N0 vs N+) were 47%/86% for reader 1 and 68%/64% for reader 2.
The detection of T3cd/T4 tumors remained a problem with MRI, and the present study revealed a low sensitivity (40%–60%) indicates that the depth of extramural invasion is largely underestimated. Low specificity estimates might be caused by desmoplastic reaction being interpreted as tumor expansion, resulting in overstaging.
Another recent study, Dam et al, found a higher sensitivity and specificity for detecting T3cd/T4. However; the MRI study of Dam et al only focused on sigmoid cancers, which could explain the higher accuracy.
The specificity of EMVI was not high, which the authors explained by possible traction on the vessels and/or thrombus formation because of altered hemodynamics caused by local inflammation.
As stated by Nerad et al, the lymph nodes are clearly visible in diffusion weighted images. This does not necessarily represent metastatic involvement, since the high cellularity in lymph nodes causes a high DWI signal in benign lymph nodes as well. False negative results are caused by microscopic metastasis in lymph nodes with a normal diameter, and false-positive results are caused by benign lymph nodes that are enlarged because of inflammation.
The study of Nerad et al used state of the art equipment and had a consecutive well-defined study population with clear endpoints, the study remained retrospective and the results had wide 95% CI´s.
More prospective research is needed to define the role of MRI in colon cancer staging, and to decide whether it become the optimal staging modality for patients with colon cancer. Although it was not the focus of the study, DWI has shown to be especially useful for locating the colon tumor. The high signal on DWI makes it easier to detect small colon tumors with MRI. The role of MRI in assessing local tumor response to neoadjuvant chemotherapy and re-staging of colonic cancer has however not been explored widely.
1. Jakobsen A, Andersen F, Fischer A, Jensen LH, Jørgensen JC, Larsen O, Lindebjerg J, Pløen J, Rafaelsen SR, Vilandt J. Neoadjuvant chemotherapy in locally advanced colon cancer. A phase II trial. Acta Oncol. 2015;54(10):1747-531.
2. Chang H, Yu X, Xiao WW, Wang QX, Zhou WH, Zeng ZF, Ding PR, Li LR, Gao YH. Neoadjuvant chemoradiotherapy followed by surgery in patients with unresectable locally advanced colon cancer: a prospective observational study. Onco Targets Ther. 2018;11:409-418.
3. Nørgaard A, Dam C, Jakobsen A, Pløen J, Lindebjerg J, Rafaelsen SR. Selection of colon cancer patients for neoadjuvant chemotherapy by preoperative CT scan. Scand J Gastroenterol. 2014;49(2):202-8
4. Rollvén E, Holm T, Glimelius B et al. Potentials of high resolution magnetic resonance imaging versus computed tomography for preoperative local staging of colon cancer. Acta Radiol. 2013;54:722-30
5. Hunter C, Blake H, Jeyadevan N et al. Local staging and assessment of colon cancer with 1.5-T magnetic resonance imaging. Br J Radiol. 2016;27:20160257
6. Hunter C, Siddiqui M, Georgiou Delisle T, Blake H, Jeyadevan N, Abulafi M, Swift I, Toomey P, Brown G. CT and 3-T MRI accurately identify T3c disease in colon cancer, which strongly predicts disease-free survival. Clin Radiol. 2017;72(4):307-315.
7. Dam C, Lindebjerg J, Jakobsen A, Jensen LH, Rahr H, Rafaelsen SR. Local staging of sigmoid colon cancer using MRI. Acta Radiol Open. 2017;6(7):205846011772095
8. Dam C, Lund-Rasmussen V, Pløen J, Jakobsen A, Rafaelsen SR. Computed tomography assessment of early response to neoadjuvant therapy in colon cancer. Dan Med J. 2015 Jul;62(7). pii: A5103
9. Choi J, Oh SN, Yeo DM, Kang WK, Jung CK, Kim SW, Park MY. Computed tomography and magnetic resonance imaging evaluation of lymph node metastasis in early colorectal cancer. World J Gastroenterol. 2015;21(2):556-62.
10. Koh FHX, Tan KK, Teo LLS, Ang BWL, Thian YL. Prospective comparison between magnetic resonance imaging and computed tomography in colorectal cancer staging. ANZ J Surg. 2017 Aug 13. doi: 10.1111/ans.14138. [Epub ahead of print]
Dr. Malene Roland V Pedersen has a Bachelor in Radiography, University College Lillebaelt, Odense 2005 and graduated with a Master of Science in Public Health from the University of Southern Denmark in 2009. She will finish her PhD study on “Imaging aspects of testicular microlithiasis” this year. She has authored and coauthored 25 peer reviewed papers. She have had the opportunity to present her scientific studies at national and international radiological meetings. Malene has a broad range of interests within research of diagnostic radiology and is working at the Department of Radiology at Vejle Hospital, Clinical Cancer Centre, Denmark. She has numerous ongoing projects and aspires to take part in further research studies in the near future.
Comments may be sent to Dr. Malene Roland V Pedersen.
Major pancreatic resections: normal postoperative findings and complications.
Marco Chincarini - Giulia A. Zamboni - Roberto Pozzi Mucelli
Insights into Imaging (2018) 9:173-187
Dr. Charikleia Triantopoulou, Head of the Radiology Department, and Dr. Paraskevi Vlachou, Consultant Radiologist, “Konstantopouleion” General Hospital of Nea Ionia, Athens-Greece.
Pancreatic adenocarcinoma is a lethal neoplasm and remains the forth cause of death in developed countries. (1) The survival rates still remain extremely low (5year-old survival less than 6%), and most of people die within 6 months after diagnosis.(2). The reason for this ‘one-way’ situation, is that pancreatic cancer is characterized by early infiltration of surrounding tissues and the early formation of distant metastases, usually synchronous with diagnosis time. The only possible curative method is tumor resection (R0) (3). Additionally, there are several other pancreatic lesions malignant, benign or intermediate that should be resected, such as mucinous cystic neoplasms, neuroendocrine tumors or chronic inflammatory lesions.
Therefore, pancreatectomy has become an important surgery, demanding highly qualified surgeons and healthcare groups to take care of the patients in dedicated centers. Pancreatoduodenectomy was first pioneered by Whipple in 1910s (3). Since then, the method has evolved throughout decades, but still remains a technically difficult procedure, carrying the risk of possible complications.
In this review article Chincarini et al., describes the most common methods of pancreatectomy, the postoperative anatomy and finally the possible complications after surgery. They use as the imaging method of choice CT, since it appears to offer many advantages, as best spatial solution, while it is a quick and cost effective method, compared to other imaging tools i.e. MRI.
Since the majority of pancreatic carcinomas are located in pancreatic head, pancreatoduodenectomy preserving pylorous or not, is the most famous operation. Both include resection of pancreatic head, duodenum, gall bladder, distal bile duct, proximal jejunum and regional lymph nodes. Furthermore other techniques are mentioned, like distal pancreatectomy with splenectomy, for lesions located at pancreatic tail and the rare central pancreatectomy. The authors underline how important is to recognize the regional anatomical changes, after the necessary anastomoses and how vital is for the radiologist to be able to point them out. CT remains the method of choice, being able to show precisely the anastomotic areas and their pathologic features, if they exist, in the majority of cases.
According to the authors, another crucial point in postoperative follow-up, is the early and direct assessment of the normal postoperative findings and the importance of not confusing them with complications or tumor recurrence. Accurate interpretation requires, understanding of which part of organ has been removed and how the remaining parts are reconstructed. (4)
The complications after pancreatoduodenectomy are many, significant and sometimes life-threatening, so, as the authors highlight, they must be recognized as soon as possible. The most common is fistula formation (11.4-64.3%) a complication associated with delayed gastric emptying, abscess formation and sepsis (5). As Bing-Yang Hu et al. refers a lot of factors are related to the formation of pancreatic fistula: gender (male>female), age, BMI>25, pancreatic duct diameter < 3mm. and soft pancreas (5-6). Other more uncommon complications are portal and SMV thrombosis, hepatic infarction, anastomotic bile leakage or stricture.
The aim of Chincarini’s article was to summarize in a brief but really helpful way the basic knowledge about various types of pancreatectomies, to refer to the anatomy and postsurgical alterations and to focus on complications that may happen. This article is a useful key, for every radiologist and enables him to be aware of fundamental findings that accompany pancreatectomies, so as to recognize them in a premature state. That demands adequate knowledge of physiologic anatomy, surgery techniques, postoperative changes and potential complications. The spherical view and deep knowledge of “pancreatectomies” and related imaging findings, make the radiologist a valuable cooperator, who can help and guide the surgeon providing him with significant details that are vital for patient’s better recovery and successful treatment.
1. Diagnosis and management of pancreatic cancer. De La Cruz MS, Young AP, Ruffin MT. Am Fam Physician. 2014 Apr 15;89(8):626-32
2. Pancreatic Cancer: why is it so hard to treat? Paul E. Oberstein, Kenneth P. Olive. Therap Adv Gastroenterol. 2013 Jul; 6(4):321-337.
3. Pancreatic Resection for pancreatic cancer. J. Bachmann, C. Michalski, M. Martignoni, M. Buchler, H. Friess. HPB (Oxford) 2006;8(5): 346-351.
4. Normal Postoperative Computed Tomography Findings after a variety of Pancreatic Surgeries. Ji Won Seo, Ho Kyoung Hwang, Ki Whang Kim, Chang Moo Kang, Myeong-Jin Kim, Yong Eun Chung. Korean J Radiol. 2017 Mar-Apr; 18(2): 299-308.
5. Risk factors for postoperative pancreatic fistula: Analysis of 539 successive cases of pancreaticoduodenectomy. Bing-Yang Hu, Tao Wan, Wen-Zhi Zhag, Jia-Hong Dong. World J. Gastroenterol. 2016 Sep 14;22(34): 7797-7805.
6. Pancreatic anastomotic leakage after pancreaticoduodenectomy. Risk factors, clinical predictors, and management (single center experience .) El Nakeeb A, Salah T, Sultan A, El Hemaly M, Askr W, Ezzat H, Hamdy E, Atef E, El Hanafy E, El-Geidie A, et al. World J Surg. 2013;37:1405–1418.
Paraskevi Vlachou, MsC, is a young radiologist in “Konstantopouleion” General Hospital of Nea Ionia-Athens. She is an active ESGAR member, attending regularly annual meetings and workshops. Her main interest is in breast and abdominal radiology. She completed a postgraduate programme at Athens University, in “Interventional Radiology” and in 2016 she won a 3 month ESOR scholarship, in Breast Imaging, at Agostino Gemelli Polyclinico in Rome.
Comments may be sent to Dr. Paraskevi Vlachou.
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas
Masao Tanaka, Carlos Fernandez-del Castillo, Terumi Kamisawa, Jin Young Jang, Philippe Levy, Takao Ohtsuka, Roberto Salvia, Yasuhiro Shimizu, Minoru Tada, Christopher L. Wolfgang
Pancreatology 17 (2017) 738-753
Dr. Charikleia Triantopoulou, Head of the Radiology Department, and Dr. Fagkrezos Dimitris, Consultant Radiologist, “Konstantopouleion” General Hospital of Nea Ionia, Athens-Greece.
Cystic pancreatic tumors and tumorlike lesions represent a wide spectrum of histopathology from purely benign to overly malignant.
The intraductal papillary mucinous neoplasm (IPMN) was first described at ERCP by Ohhashi in 1982  and the first report in the imaging literature was by Itai et al. in 1986 . The lesion occurs with a slightly increased frequency in male patients compared with other pancreatic cysts. IPMN is pathologically characterized by papillary proliferation of ductal epithelium in the main or branch duct, association with ductal dilatation, and various mucin productions . IPMNs are subcategorized clinically into main duct type, branch duct type and combined type. There are five histologic types: Gastric, intestinal, pancreatobilliary, intraductal, tuburopapillary and intraductal oncocytic. The different histologic types cannot be differentiated on imaging; however, the risk of malignancy varies significantly between them. Factors correlating with malignancy include advanced age, main duct involvement, concurrent diabetes or other pancreas related abdominal symptoms, lesion size (>3cm), multiplicity and presence of visible mural nodules.
In this article Masao Tanaka and the rest of the working group, based on a consensus symposium that took place in Sendai of Japan in 2016, did not recognize the need for major revisions of the previous guidelines of 2012 in Fukuoka, making only minor revisions and added most recent articles where appropriate. The working group has revised the guidelines regarding prediction of invasive carcinoma and high grade dysplasia, surveillance, and postoperative follow up of IPMN.
As a consequence, the majority of newly-diagnosed BD-IPMNs do not undergo surgery. However, it is also recognized that a proportion of these evolve over time and can become malignant, and also, that patients with IPMN are at increased risk of developing conventional pancreatic ductal adenocarcinoma elsewhere in the gland. Because of this, surveillance is carried out on most of these patients.
The authors make an important reference to the role of imaging in classification of lesions. They mention that it is very important for clinicians to plan the management of IPMN, which should be based on the preoperative radiologic images, and the pathological classification can be specified a posteriori.
Symptomatic cysts overall have a higher risk of invasive carcinoma and HGD, and, depending on the clinical circumstances, either resection or further evaluation needs to be carried out.
“Worrisome features” on imaging include cyst of ≥3 cm, enhancing mural nodule <5 mm, thickened enhanced cyst walls, MPD size of 5-9 mm, abrupt change in the MPD caliber with distal pancreatic atrophy, lymphadenopathy, an elevated serum level of carbohydrate antigen (CA)19-9 and a rapid rate of cyst growth > 5 mm/2 years [4-5]. '
These patients should be evaluated by endoscopic ultrasonography (EUS) to further stratify the lesion. Doppler EUS or contrast-enhanced harmonic EUS can demonstrate the presence of blood supply in mural nodule [6,7,8]. Cysts with obvious “high-risk stigmata” on CT, MRI, or EUS (i.e. obstructive jaundice in a patient with a cystic lesion of the pancreatic head, enhanced mural nodule ≥5 mm, MPD size of ≥10 mm) should undergo resection in surgically fit patients without further testing . All patients with cysts of ≤3 cm in size without “worrisome features” should undergo surveillance according to size stratification.
Although preoperative and intraoperative assessment of the grades of dysplasia of IPMNs can be difficult, ultrasonography, CT, MRI, and EUS will identify most tumors with a significant invasive component. In such patients, pancreatoduodenectomy, left pancreatectomy, or total pancreatectomy according to the site and extent of the disease with lymph node dissection remains the standard treatment.
The purpose of this article is to enhance the latest knowledge in the management of patients with known pancreatic cystic neoplasms of IPMN type.
This article is a useful tool for every radiologist, especially those participating in oncologic multidisciplinary meetings, and enables them to be aware of the most recent and up-to-date information and recommendations for the proper management of IPMN.
1. Ohhashi K, Murakami Y, Maruyama M, et al.: Four cases of mucus secreting pancreatic cancer. Prog Dig Endosc. 1982; 20:348-351
2. Itai Y, Ohhashi K, Nagai H, et al.: “Ductectatic” mucinous cystadenoma and cystadenocarcinoma of the pancreas. Radiology 1986; 161:697-700
3. Tierney WM, Francis IR, Eckhauser F, et al.: The accuracy of EUS and helical CT in the assessment of vascular invasion by peripapillary malignancy. Gastrointest Endosc 2001; 53:182-188
4. Kang MJ, Jang JY, Kim SJ, Lee KB, Ryu JK, Kim YT, et al. Cyst growth rate predicts malignancy in patients with branch duct intraductal papillary mucinous neoplasms. Clin Gastroenterol Hepatol 2011; 9:87-93.
5. Kwong WT, Lawson RD, Hunt G, Fehmi SM, Proudfoot JA, Xu R, et al. Rapid growth rates of suspected pancreatic cyst branch duct intraductal papillary mucinous neoplasms predict malignancy. Dig Dis Sci 2015; 60:2800-6.
6. Ohno E, Hirooka Y, Itoh A, Ishigami M, Katano Y, Ohmiya N, et al. Intraductal papillary mucinous neoplasms of the pancreas: differentiation of malignant and benign tumors by endoscopic ultrasonography findings of mural nodules. Ann Surg 2009; 249:628-34.
7. Kitano M, Sakamoto H, Komaki T, Kudo M. New techniques and future perspective of EUS for the differential diagnosis of pancreatic malignancies: contrast harmonic imaging. Dig Endosc 2011; 23(Suppl 1):46-50.
8. Ohno E, Itoh A, Kawashima H, Ishikawa T, Matsubara H, Itoh Y, et al. Malignant transformation of branch duct-type intraductal papillary mucinous neoplasms of the pancreas based on contrast-enhanced endoscopic ultrasonography morphological changes: focus on malignant transformation of intraductal papillary mucinous neoplasm itself. Pancreas 2012; 41:855-62.
9. Kim TH, Song TJ, Hwang JH, Yoo KS, Lee WJ, Lee KH, et al. Predictors of malignancy in pure branch duct type intraductal papillary mucinous neoplasm of the pancreas: a nationwide multicenter study. Pancreatology 2015; 15:405-10.
Dr. Fagkrezos Dimitris graduated from medical school of Patras University and completed a Master of Science programme in “Interventional Radiology” at Athens University. He is a consultant radiologist at the Computed Tomography Department in “Konstantopouleion” General Hospital of Nea Ionia-Athens. He is an active ESGAR member, attending regularly annual meetings and workshops. His main interest is in abdominal, oncologic and cardiovascular radiology. Dr Fagkrezos has a broad range of interests within research of diagnostic radiology.
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Diagnostic prediction of complicated appendicitis by combined clinical and radiological appendicitis severity index (APSI)
Authors: Avanesov M, Wiese NJ, Karul M, Guerreiro H, Keller S, Busch P, Jacobsen F, Adam G,
Journal: Eur Radiol. 2018 Sep;28(9):3601-3610. doi: 10.1007/s00330-018-5339-9.
Dr. Asuncion Torregrosa, ESGAR Fellow and Head of the Abdominal Radiology Section and Dr. Alexandre Perez Girbes, ESGAR Member and abdominal radiologist, both in University and Polytechnic La Fe Hospital, Valencia (Spain)
Acute appendicitis (AA) is one of the most common abdominal emergencies, with life time prevalence of about 7-8% (1). Since 19th century, urgent surgery has been the standard treatment for acute appendicitis (2). However, in last decades several clinical trials have compared surgery against conservative treatment with antibiotics concluding that this is as safe and effective as appendectomy.
The objective of Avanesov et al. is to propose a severity index based in clinical and radiological features to predict complicated AA.
Their retrospective study included 200 adult patients with histologically proven acute appendicitis who had a presurgical contrast-enhanced CT with evidence of AA and availability of selected clinical and biological parameters on admission (body temperature, duration of symptoms before admission, C reactive protein and WBC count).
All CT studies were visually evaluated for appendix diameter, wall thickness and the presence of periappendiceal fat stranding and fluid, intraluminal air in appendix, thinning of appendiceal wall, extraluminal air, caecal wall thickening, appendicolith and perityphlitic abscess.
Surgical and histopathological evaluation grouped AA as uncomplicated (mucosal and suppurative AA) or complicated (gangrenous and perforated AA) according to changes and density of neutrophil infiltration in the wall. Perforation was assessed intraoperatively.
Among the patients included, half of the patients (51%, n=103) had complicated AA, while 49% had uncomplicated AA.
Authors developed a multivariate logistic regression model, appendicitis severity index (APSI), with 7 selected parameters (3 clinical and 4 radiological). They defined points for APSI calculation based on the corresponding β regression coefficient of each parameter. Clinical parameters were: age ≥52 years (1 point), body temperature ≥37.5 °C, (1 point), duration of symptoms ≥48 h (1 point) and the radiological ones: appendix diameter ≥14 mm (1 point), presence of periappendiceal fluid (2 points), extraluminal air (1 point), and abscess present (3 points).
Their results showed that the best discriminative capacity of APSI was observed for ≥ 4 points with an AUC of 0.92, a sensitivity of 82%, specificity of 93%, accuracy of 87%, PPV of 92% and NPV of 83%. The median APSI was significantly lower in patients with uncomplicated AA compared to those with complicated AA [1 (IQR, 1-2) vs 5 (IQR, 4-6), p < 0.001)].
Previously, other authors studied imaging features to differentiate uncomplicated AA from complicated AA. A recently published systematic review by Kim HY et al. (3) identified 10 CT features informative for complicated AA. Almost all of them showed high specificity but low sensitivity. Other papers examined the same comparison by US findings. A paper by Xu et al. (4) which compared US findings between complicated and uncomplicated AA showed that only loss of the normally echogenic submucosal layer had an independent association to complicated appendicitis in multivariate regression. Atema and colleagues (5) were the first to propose a clinical-radiological score to differentiate uncomplicated AA from complicated AA. They proposed a more detailed score with maximum 22 points for CT and 19 for US, with AUC of 0.90 and 0.85, respectively.
According with the authors, we find very interesting to differentiate with image techniques between uncomplicated AA from complicated AA due to the new trends in the treatment. Published data suggests that will be feasible avoid surgery and its inherent risks in case of mild or very early AA.
Nevertheless, we encourage the US role in the management of patients with right lower quadrant pain with suspected AA in emergency department. AA is more common in young adults and children, who are more sensitive to ionizing radiation exposure than adults, being US the first choice technique to evaluate this clinical scenario. So, in our opinion severity index based on clinical and US criteria, as above mentioned, would be more applicable in that population. The same occurs in patients no candidates to intravenous contrast administration.
This paper is interesting for radiologists working in the emergency department or that are on duty, whose authors propose a reasonably easy appendicitis severity score (APSI) with high PPV and NPV for predicting complicated AA. Furthermore, the important role of the radiologists in diagnostic process of AA is very well shown helping the surgeon to make a decision between surgical and non-surgical treatment.
The main weakness of this study is its single-center retrospective design. External validation with larger cohorts is needed to use confidently APSI in clinical practice.
1. Addiss DG, Shaffer N, Fowler BS et al. The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol. 1990 Nov;132(5):910-25
2. Richardson WS. The evolution of early appendectomy as standard treatment from appendicitis: what we can learn from the past in adopting new medical therapies. Am Surg. 2015 Feb;81(2):161-5
3. Kim HY, Park JH, Lee YJ et al. Systematic Review and Meta-Analysis of CT Features for Differentiating Complicated and Uncomplicated Appendicitis. Radiology. 2018 Apr;287(1):104-115
4. Xu Y, Jeffrey RB, Chang ST et al. Sonographic Differentiation of Complicated From Uncomplicated Appendicitis: Implications for Antibiotics‐First Therapy. J Ultrasound Med. 2017 Feb;36(2):269-277.
5. Atema JJ, van Rossem CC, Leeuwenburgh MM, Stoker J, Boermeester MA. Scoring system to distinguish uncomplicated from complicated acute appendicitis. Br J Surg. 2015 Jul;102(8):979-9
Dr. Alexandre Perez-Girbes is a young radiologist at University and Polytechnic La Fe Hospital, Valencia (Spain). He completed his radiology residency last year. During his training, Alexandre actively assisted in ESGAR workshops and participated in the local organising team of Junior ESGAR Summer School held in Valencia in 2016. He is also member of the ESGAR Research Committee. His main interest is clinical radiology and research, especially abdominal imaging. He also co-authored peer reviewed neuroradiology papers.
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Abdominal imaging findings in adult patients with Fontan circulation.
Authors: Tae-Hyung ,Kim, Hyun Kyung, Yang. Hyun-Jung, Jang. Shi-Joon, Yoo. Korosh, Khalili. Tae Kyoung, Kim.
Journal: Insights into Imaging. 2018; 9: 357–67. doi.org/10.1007/s13244-018-0609-2.
Dr. Asuncion Torregrosa, ESGAR Fellow and Head of the Abdominal Radiology Section and Dr. Helena Martinez-Maicas radiologist resident of last year, both working on University and Polytechnic La Fe Hospital, Valencia (Spain).
The Fontan procedure  was designed to treat patients with single functional ventricle, by-passing right ventricle, what implies the transmission of pulmonary vascular resistance to systemic venous circulation. This inevitably provokes elevation of systemic venous pressure. Improving of surgical technique and postoperative management markedly prolongs patient survival, frequently until adulthood. Radiologists must be aware of this technique and the possible complications in order to summit a correct and early diagnosis.
This article is a descriptive review of post-Fontan abdominal findings in adults patients, focused on hepatic changes.
Fontan associated liver disease (FALD) is originated by chronic hepatic congestion similar to right heart failure and can lead to liver cirrhosis, portal hypertension, focal nodular hyperplasia (FNH)-like and even hepatocellular carcinoma.
The liver is often enlarged with caudate lobe hypertrophy and irregular parenchymal fatty infiltration with perivascular distribution. The most common imaging feature in FALD is heterogeneous hepatic enhancement with mosaic or reticular pattern, resulting from slow and poor enhancement near the congested hepatics veins . This abnormal enhancement is more evident in the periphery of the liver parenchyma and in the portal venous phase.
Regenerative hepatic nodules are commonly seen in adult patients with FALD whose prevalence ranges from 20 to 30% . FNH-like nodules in FALD are often small and multiple and show a predilection for the periphery of the right lobe . It is important to note that benign and arterially enhancing nodules may show portal venous or delayed phase washout, mimicking hepatic carcinoma (HCC) and becoming a challenge for radiologists. Wells et al. speculated that the washout may be related to the background parenchymal contrast retention due to congestion and fibrosis or from a predominant hepatic arterial supply . MRI using liver-specific contrast agent and DWI may be useful for the differentiation between FNH-like nodules and HCC, as HCC mostly show hypointensity in the hepatobiliary phase and restricted diffusion . These authors suggested other ancillary findings favoring benign FNH-like nodules, including hypointensity on T2-weighted images and stability over time (>24months) .
Vascular abnormalities in post-Fontan patients are similar to congestive heart failure with earlier development. Inferior cava vein and hepatic veins are dilated with increased pulsatility, regardless of the surgical technique. In contrast, the diameter of main portal vein and intrahepatic portal veins is usually small, possibly due to reduction of portal perfusion secondary to increase in sinusoidal pressure with venous stasis .
Splenomegaly and ascites are commonly seen in adult Fontan patients. Thus, extrahepatic portosystemic shunts are uncommon or small in size, what is likely due to the high systemic venous pressure and relatively low pressure gradient between the portal and systemic veins .
Protein losing enteropathy is a severe condition with usually delayed diagnosis. Suggestive imaging findings including ascites, diffuse bowel wall thickening, and mesenteric edema on CT or MRI should prompt a clinical evaluation to rule it out.
The improvement in post-Fontan patient surveillance makes necessary a comprehensive approach by the radiologist. Given the clinical importance of FALD, liver biopsy has been the “gold standard” for diagnosis. Nevertheless, FALD can be not uniformly distributed  and complications related to biopsy are higher in this group of patients, with frequent use of warfarin and elevated systemic venous pressure. Non-invasive imaging surveillance may be essential in guiding patient management and discard potential severe complications.
1. Fontan F, Mounicot FB, Baudet E, Simonneau J, Gordo J, Gouffrant JM. “Correction” of tricuspid atresia. 2 cases “corrected” using a new surgical technic. Ann Chir Thorac Cardiovasc. 1971; 10:39–47.
2. Bulut OP, Romero R, Mahle WT, McConnell M, Braithwaite K, Shehata BM et al. Magnetic resonance imaging identifies unsuspected liver abnormalities in patients after the Fontan procedure. J Pediatr. 2013; 163:201-6.
3. Bryant T, Ahmad Z, Millward-Sadler H et al. Arterialized hepatic nodules in the Fontan circulation: hepatic-cardiac interactions. Int J Cardiol. 2011; 151:268–72.
4. Bae JM, Jeon TY, Kim JS et al. Fontan-associated liver disease: spectrum of US findings. Eur J Radiol. 2016; 85:850–56.
5. Wells ML, Hough DM, Fidler JL, Kamath PS, Poterucha JT, Venkatesh SK. Benign nodules in post-Fontan livers can show imaging features considered diagnostic for hepatocellular carcinoma. Abdom Radiol. 2017; 42: 2623-31.
6. Cura M, Haskal Z, Lopera J. Diagnostic and interventional radiology for Budd-Chiari syndrome. RadioGraphics. 2009; 29:669–81.
7. Wells ML, Fenstad ER, Poterucha JT, Hough DM, Young PM, Araoz PA et al. Imaging findings of congestive hepatopathy. RadioGraphics. 2016; 36:1024–37.
8. Poterucha JT, Johnson JN, Qureshi MY, O´Leary PW, Kamath PS, Lennon RJ et al. Magnetic Resonance Elastography: a novel technique for the detection of hepatic fibrosis and hepatocellular carcinoma after the Fontan operation. Mayo Clin Proc. 2015; 90:882–94.
Helena Martinez-Maicas is a radiologist in her last days of Radiology residency at the University and Polytechnic La Fe Hospital. Previously, she focused on Intensive Care Medicine but redirected her professional career to Radiology. She has been particularly interested in abdominal radiology and was able to work extensively in this area during her residency.
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Pancreatic Adenocarcinoma Staging in the Era of Preoperative Chemotherapy and Radiation Therapy
Authors: Marc Zins, Celso Matos, Christophe Cassinotto
Journal: Radiology Vol 287, No.2 (2018). https://pubs.rsna.org/doi/full/10.1148/radiol.2018171670
Dr. João Pinheiro Amorim, radiologist resident of 4th year, and Prof. Manuela França, ESGAR Fellow and Head of Radiology Department, both working at the University Oporto Hospital Centre, Oporto (Portugal).
Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignancy, usually locally advanced or metastatic at diagnosis, with high mortality rate and challenging treatment. Accurate determination of the extent of disease during initial PDA staging is extremely important for determining patient management during multidisciplinary team discussion (1). As surgical resection of non-metastatic disease is considered the only potentially curative treatment, many strategies are being developed to increase the number of surgical candidates, which was traditionally low.
The standard of care for PDA considered resectable at diagnosis is surgery followed by adjuvant chemotherapy. Nevertheless, neoadjuvant therapy followed by surgery is increasingly being considered for selected patients at high risk for resection margin involvement, aiming to increase the likelihood of negative resection margins and curative surgery, as well for downstaging tumors that were locally advanced at initial PDA staging (2). These changes in the patient management lead to new diagnostic imaging challenges, not only for the initial stating as also for the assessment of neoadjuvant treatment response.
In the setting of important changes in current PDA management, the authors provide an important review and commentaries on PDA staging, highlighting the rationale for the increasing use of neoadjuvant therapy, which will have important implications on pre-operative imaging assessment.
The authors discuss what should be the radiologist’s strategy for PDA staging, which is mostly focused on arterial and venous involvement to assess unresectability criteria related to vascular spread, classifying tumors in resectable, borderline resectable or unresectable/locally advanced (2, 3). Nevertheless, this three-stage classification system that is the based on the current National Comprehensive Cancer Network (NCCN) classification has important limitations, and the definition of borderline resectable tumors has been a cause of intense debate in the last years. Therefore, the authors encourage a more detailed staging in order to estimate the likelihood of achieving R0 margins and to guide treatment planning, allowing for neoadjuvant therapy consideration when the risk of incomplete resection is high.
The limitations of current staging techniques are also considered in this paper, and some improvements are suggested. Multiphasic computed tomography (CT) is currently the method of choice for initial PDA staging, particularly due to its superb spatial resolution. Nevertheless, its diagnostic capability is limited for detecting isoattenuating tumors (4) and, moreover, for the assessment of important prognostic factors affecting tumor staging, including perineural invasion, lymph node involvement and liver metastasis detection.
Magnetic Resonance (MR) imaging has high sensitivity for staging isoattenuating tumors with little or no visibility on initial multidetector CT. Furthermore, MR imaging of the liver has higher sensitivity than multidetector CT for detecting small liver metastasis, changing treatment management in up to 10% of patients after liver metastasis detection (5,6). Therefore, the authors feel that recent evidence supports hepatic MR imaging as a mandatory examination in patients with PDA considered resectable on multidetector CT. MR imaging should also be performed before and after neoadjuvant treatment for borderline resectable or locally advanced PDA.
Dual-energy (spectral) CT may improve tumor detection and staging but more studies are needed to determine if it significantly improves the prediction of negative margin resection in everyday clinical practice.
On the other hand, hybrid imaging still does not have a definite role in PDA staging.
Regarding the raising importance of neoadjuvant therapy, particularly in borderline resectable or locally advanced tumors, the authors highlight that current structural imaging techniques and criteria are clearly insufficient and warrant great caution for radiologists (7). In fact, the performance of multidetector CT in predicting resectability decreases after neoadjuvant therapy and the criteria of radiological response frequently underestimate the histologic treatment response (8). For the time being, patients with evidence of any degree of radiological improvement in tumor size and/or tumor-vessel contact, even if small, should be considered good candidates for surgery, since there might be a good histological response. For the future, the use of functional imaging methods is pointed as a particularly interesting and promising research field (9).
(1) Fogel EL, Fogel EL, Shahda S, Sandrasegaran K, et al. A multidisciplinary approach to pancreas cancer in 2016: a review. Am J Gastroenterol 2017;112(4):537–554.
(2) National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology. Pancreatic adenocarcinoma. Version 2.2016. Fort Washington, Pa: National Comprehensive Cancer Network 2017.
(3) Varadhachary GR, Tamm EP, Abbruzzese JL, et al. Borderline resectable pancreatic cancer: definitions, management, and role of preoperative therapy. Ann Surg Oncol 2006;13(8):1035–1046.
(4) Kim JH, Park SH, Yu ES, et al. Visually isoattenuating pancreatic adenocarcinoma at dynamic-enhanced CT: frequency, clinical and pathologic characteristics, and diagnosis at imaging examinations. Radiology 2010;257(1):87–96.
(5) Kim HW, Lee JC, Paik KH, et al. Adjunctive role of preoperative liver magnetic resonance imaging for potentially resectable pancreatic cancer. Surgery 2017;161(6):1579–1587.
(6) Marion-Audibert AM, Vullierme MP, Ronot M et al. Value of routine MRI with diffusion weighted- sequences for the detection of liver metastases in patients with potentially resectable pancreatic ductal carcinoma and normal liver CT: a prospective multicentre study. AJR Am J Roentgenol: W1-W9. 10.2214/AJR.18.19640.
(7) Katz MH, Fleming JB, Bhosale P, et al. Response of borderline resectable pancreatic cancer to neoadjuvant therapy is not reflected by radiographic indicators. Cancer 2012;118(23):5749–5756.
(8) Cassinotto C, Cortade J, Belleannée G, et al. An evaluation of the accuracy of CT when determining resectability of pancreatic head adenocarcinoma after neoadjuvant treatment. Eur J Radiol 2013;82(4): 589–593.
(9) Cassinotto C, Chong J, Zogopoulos G, et al. Resectable pancreatic adenocarcinoma: Role of CT quantitative imaging biomarkers for predicting pathology and patient outcomes. Eur J Radiol 2017;90:152–158.
Dr. João Amorim is a young radiology resident in the last years of training at the University Hospital of Centro Hospitalar do Porto, Portugal. He completed his undergraduate medical degree at the University of Minho in 2013. He is an active member of ESGAR and is regularly attending workshops organised by the society. His main interest is in abdominal and oncologic radiology and currently, he is taking part in research studies at his institution, particularly focused on imaging biomarkers and quantitative research and its translation to clinical practice.
Comments may be sent to: firstname.lastname@example.org
Reference range of liver corrected T1 values in a population at low risk for fatty liver disease—a UK Biobank sub-study, with an appendix of interesting cases
Authors: Mojtahed A, Kelly CJ, Herlihy AH, Kin S, Wilman HR, McKay A, Kelly M, Milanesi M, Neubauer S, Thomas EL, Bell JD, Banerjee R, Harisinghani M.
Journal: Abdom Radiol (NY). 2018 Jul 21. doi: 10.1007/s00261-018-1701-2. [Epub ahead of print] PubMed PMID: 30032383.
Prof. Andrea Laghi, ESGAR Vice President and Head of the Abdominal Radiology Department and Dr. Marta Zerunian, ESGAR Member and radiologist resident attending the third year, both working in the Department of Radiological Sciences, Oncological and Pathological Sciences University of Rome "Sapienza" Radiology Unit - Sant'Andrea University Hospital, Rome (Italy).
Nowadays liver disease is increasingly taking the lead among the causes of death in Western countries, in relation to the increase in obesity in the population(1). Even if steatosis (non-alcoholic fatty liver-NAFL) is not considerable as a manifest liver disease, it represents a precursor of liver inflammation (non-alcoholic steatohepatitis-NASH), fibrosis and cirrhosis, all conditions that lead to higher risk of morbidity and mortality(2). Until clinical symptoms are present the diagnosis of liver disease is difficult and that limits drastically the treatment options to keep under control the progression of the disease(3). Studies about hepatic multiparametric magnetic resonance imaging (MRI) demonstrated the prognostic role of the technique in the diagnosis of chronic liver disease and in the identification, through quantitative approach, of early stage of liver fibrosis in comparison with biopsy(4). Liver composition is objectively quantifiable with proton density fat fraction (PDFF) or T1 relaxation times, allowing furthermore a comparison of values across populations. Another powerful instrument of this new MRI tool is the Liver Inflammation and Fibrosis score, which is based on iron corrected T1 (cT1). cT1 is a novel imaging biomarker based on T1 mapping technology, which takes advantage of the increases in extracellular tissue fluid that occur in response to inflammation and fibrosis, with the possibility to correct values for elevated iron content. Preliminary studies demonstrated how cT1 can predict some liver-related clinical outcomes but the technique and the range of normality need some standardization in order to differentiate normality and different stage of abnormality (NAFL or NASH)(5).
Mojtahed and colleagues aimed to provide a set of reference values for cT1 within a low-risk for fatty liver disease population. Reference population at low risk for NASH and NAFL (PDFF<5% and BMI< 25 kg/m2) counting 1037 subjects, was selected from the largest prospective population study in history, UK Biobank(6); comparison cohorts with PDFF >5% and/or BMI> 25 included 1779 individuals. MR protocol was acquired at 1.5 T, in a transverse slice located at the porta hepatis; two rapid sequences were used: a Shortened Modified Look Locker Inversion (ShMOLLI)(7) and a multiecho spoiled-gradient-echo. The T1 relaxation map acquired using the ShMOLLI sequence resulted with a decrease T1 due to the excess of iron, bias removed by an algorithm, which can be calculated from the T2* maps(8), from the T1 measurements, providing the cT1(9). Images were analyzed with a dedicated software and for each T2*, cT1 and PDFF image were drawn three circular region of interest (ROI).
Results showed a cT1 median value of 666.0 ms for the reference group (both non-overweight and non-steatotic). Results were also compared with high risk subcohorts of non-overweight but steatotic patients (median cT1 of 712.5 ms), overweight but non-steatotic (median cT1 of 681.7 ms), and overweight and steatotic (median cT1 of 744.7). The comparison showed a cT1 values significantly higher in the higher-risk cohorts that the reference cohort.
There were not significant differences of the cT1 values between woman and men and among age groups in men while significant decrease of cT1 values were observed in women between ages of 40-49 and 60-69 years.
As previously reported by Scaglione et al.(3) there is a wide percentage of people affected by cirrhosis in US and identifying those individuals at risk of cirrhosis before it develops would be of enormous utility. To establish quantitative imaging biomarkers and to define normal range of them is essential in order to assess the presence, absence, or change of disease over time. In this contest the Authors hypothesize that participants with high cT1 values are more likely to suffer clinical outcomes. In addition, they underline that age and gender have a negligible influence on cT1, without needs of cT1 correction. The small, but statistically significant, increase in cT1 in the youngest female group, can be assumed to be pre-menopausal and estrogen levels related. Despite some limitation due to restricted age range (40-79 years) and definition of low-risk population just only with BMI and PDFF values, this article assesses, for the first time, the MRI reference range of cT1 values in a large population at low risk for NAFL, representing a benchmark for future studies regarding MR imaging biomarker for the quantitative assessment of fatty liver disease.
1. Hu K-C, Wang H-Y, Liu S-C, et al. (2014) Nonalcoholic fatty liver disease: updates in noninvasive diagnosis and correlation with cardiovascular disease. World J Gastroenterol 20:7718– 7729
2. Lade A, Noon LA, Friedman SL (2014) Contributions of metabolic dysregulation and inflammation to nonalcoholic steatohepatitis, hepatic fibrosis, and cancer. Curr Opin Oncol 26:100– 107
3. Scaglione S, Kliethermes S, Cao G, et al. (2015) The epidemiology of cirrhosis in the United States: a population-based study. J Clin Gastroenterol 49:690– 696
4. Banerjee R, Pavlides M, Tunnicliffe EM, et al. (2014) Multipara- metric magnetic resonance for the non-invasive diagnosis of liver disease. J Hepatol 60:69– 77
5. Pavlides M, Banerjee R, Sellwood J, et al. (2016) Multiparametric magnetic resonance imaging predicts clinical outcomes in patients with chronic liver disease. J Hepatol 64:308– 315
6. UK Biobank. (n.d.). http://www.ukbiobank.ac.uk
7. Piechnik SK, Ferreira VM, Dall’Armellina E, et al. (2010) Short- ened Modified Look-Locker Inversion recovery (ShMOLLI) for clinical myocardial T1-mapping at 1.5 and 3 T within a 9 heartbeat breathhold. J Cardiovasc Magn Reson 12:69
8. Wood JC, Enriquez C, Ghugre N, et al. (2005) MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease pa- tients. Blood 106:1460– 1465. doi.org/10.1182/blood-2004- 10-3982
9. Tunnicliffe EM, Banerjee R, Pavlides M, Neubauer S, Robson MD (2017) A model for hepatic fibrosis: the competing effects of cell loss and iron on shortened modified Look-Locker inversion recovery T1(shMOLLI-T1) in the liver. J Magn Reson Imaging 45:450– 462. doi.org/10.1002/jmri.25392 '
Dr. Marta Zerunian is a young radiology resident attending the third year of residency at the University of Rome "Sapienza" - Sant'Andrea University Hospital in Rome. She has been particularly interested in abdominal and oncologic radiology and was able to work extensively in this area during her residency focusing in particular on imaging quantitative biomarkers.
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Hepatobiliary MRI as novel selection criteria in liver transplantation for hepatocellular carcinoma
Ah Yeong Kim, Dong Hyun Sinn, Woo Kyoung Jeong, Young Kon Kim, Tae Wook Kang, Sang Yun Ha, Chul Keun Park, Gyu Seong Choi, Jong Man Kim, Choon Hyuck David Kwon, Jae-Won Joh, Min-Ji Kim, Insuk Sohn, Sin-Ho Jung, Seung Woon Paik, Won Jae Lee
J Hepatol 2018; 68:1144-1152. doi.org/10.1016/j.jhep.2018.01.024
Dr. Ana Margarida Alves, Resident, Department of Radiology, Oporto Hospital and University Centre, Oporto (Portugal).
Prof. Dr. Manuela França, Hospitalar Assistant and Head of Radiology Department, Oporto Hospital and University Centre, Oporto (Portugal).
Liver transplantation is a well-established indication for patients with early-stage hepatocellular carcinoma (HCC) and is available in most developed countries. Milan criteria are considered the gold standard for selecting these patients for liver transplantation and include: single nodule up to 5 cm; up to three nodules, none larger than 3 cm and no evidence of extrahepatic spread or macrovascular invasion . In recent years, these morphological criteria have been subject of controversy because they might be too restrictive, rejecting patients with HCC whose liver transplantation would be potentially curative .
Several studies have shown that HCC biology, such as microvascular invasion and tumor grade, is an important predictor of tumor recurrence after liver transplantation, but these features can only be evaluated from the explanted liver . Consequently, many recent investigations aimed to establish clinical, analytical or imaging predictors of these histopathological tumor features .
The objective of Kim AY et al. was to assess the risk of tumor recurrence after liver transplantation for HCC, based on pre-transplant gadoxetic acid-enhanced MRI features.
Their retrospective study included 100 patients who received a liver transplant and had undergone pre-operative gadoxetic acid-enhanced MRI with hepatobiliary phase (HBP) from January 2009 to December 2013. All patients were evaluated for Milan criteria, tumor size, number and morphological type, tumor margins, satellite nodules, peritumoral enhancement in arterial phase, capsule or pseudocapsule in portal venous phase, peritumoral hypointensity on the HBP and apparent diffusion coefficients (ADC). The authors also evaluated the histopathological features of HCC in the explanted livers, including microvascular invasion and intrahepatic metastasis. The primary endpoint was time to recurrence.
During the follow-up period, HCC recurrence was detected in 33 of 100 patients. In the univariate analyses, tumors with perinodular extension or a confluent multinodular type, a satellite nodule, peritumoral enhancement in the arterial phase, peritumoral hypointensity on the HBP and a lower ADC value were significantly associated with recurrence after liver transplantation in the overall group. In the multivariable-adjusted model including these factors, the presence of a satellite nodule (HR 3.07; 95% CI, 1.14–8.25) and peritumoral hypointensity on the HBP (HR 4.53; 95% CI, 1.53–13.44) were independent factors associated with recurrence. When patients were stratified according to the Milan criteria, recurrence-free survival was significantly better for those without high-risk radiological findings and who were transplanted either within the Milan criteria (88.4% vs. 33.3% at three years, p <0.001) or outside the Milan criteria (71.4% vs. 24.5% at three years, p <0.001). Most of the patients with high-risk radiological findings had microvascular invasion on histology (95%) and most of the patients without microvascular invasion on histology showed negative high-risk radiological findings (98%).
According to the authors, the presence of satellite nodule and peritumoral hypointensity on HBP can independently predict tumor recurrence, either in patients transplanted within or outside the Milan criteria. They also suggest that the positive predictive value and specificity of these two high-risk radiological findings are adequately high for the prediction of histological microvascular invasion.
These results are consistent with previous studies. Plessier et al. suggested that satellite lesions have a strong correlation with microvascular invasion and are an important cause of HCC recurrence . Kim et al. described that peritumoral hypointensity on HBP images is a strong predictor of microvascular invasion and the decreased uptake of gadoxetic acid by hepatocytes around the tumor probably reflects the hemodynamic changes caused by minute portal venous invasion .
This study has some limitations, such as its retrospective nature with potential selection bias. The study population was constituted mainly by patients with hepatitis B virus infection and, moreover, some of the patients had undergone prior treatments, such as transarterial chemoembolization, that could modify the MRI findings. However, the high-risk radiological findings were associated with recurrence-free survival either in treatment-naïve or treated patients.
In conclusion, hepatobiliary MRI might be a valuable tool for optimizing the selection criteria for liver transplantation in HCC patients, but additional multicentric studies are needed for definitive validation.
1. European Association For The Study Of The Liver & European Organization For Research And Treatment Of Cancer. EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. J. Hepatol 2012; 56:908–943.
2. Yao FY, Roberts JP. Applying expanded criteria to liver transplantation for hepatocellular carcinoma: Too much too soon, or is now the time? Liver Transpl 2004; 10:919–921.
3. Mazzaferro V, Llovet JM, Miceli R, Bhoori S, Schiavo M, Mariani L, et al. Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis. Lancet Oncol 2009; 10:35–43.
4. Silva, M. F. & Sherman, M. Criteria for liver transplantation for HCC: what should the limits be? J. Hepatol 2011; 55:1137–1147.
5. Plessier A, Codes L, Consigny Y, Sommacale D, Dondero F, Cortes A, et al. Underestimation of the influence of satellite nodules as a risk factor for post-transplantation recurrence in patients with small hepatocellular carcinoma. Liver Transpl 2004; 10:S86–S90.
6. Kim KA, Kim MJ, Jeon HM, Kim KS, Choi JS, Ahn SH, et al. Prediction of microvascular invasion of hepatocellular carcinoma: usefulness of peritumoural hypointensity seen on gadoxetate disodium-enhanced hepatobiliary phase images. J Magn Reson Imaging 2012; 35:629–634.
Dr. Ana Margarida Alves is a third-year radiology resident at Oporto Hospital and University Centre in Portugal. She graduated as a medical doctor at the Faculty of Medicine of Oporto University in July 2014. She is an active ESGAR member and regularly attends ESGAR annual meetings and workshops. Currently, she has a broad range of interests in diagnostic abdominal radiology, particularly liver and bowel imaging.
Comments may be sent to: firstname.lastname@example.org
Andrew D. Smith, Cody R. Branch, Kevin Zand, Charu Subramony, Haowei Zhang, Katherine Thaggard, Richard Hosch, Jason Bryan, Amit Vasanji, Michael Griswold, Xu Zhang.
Liver Surface Nodularity Quantification from Routine CT Images as a Biomarker for Detection and Evaluation of Cirrhosis. Radiology. 2016 Sep; 280(3):771-81
Cedric Bohyn – Resident, Department of Radiology, AZ Delta Hospital Roeselare & University Hospitals Leuven, Belgium
Philippe Lefere – Department of Radiology, AZ Delta Hospital Roeselare, Belgium
The goal of this retrospective study was to assess the feasibility of distinguishing a cirrhotic from a non-cirrhotic liver on routine CT-images by the use of a semi-automated scoring system that quantifies the liver surface nodularity (LSN).
Performing a liver biopsy remains the gold standard in determining the cirrhotic stage of a liver. The sensitivity and specificity for accurate diagnosis of cirrhosis and its etiology ranges from 80 to 100 percent (1). However, biopsy should only be considered after non-invasive serologic and radiologic evaluation failed to confirm a diagnosis. The reason is that biopsy has many inherent risks like its invasive nature, sampling error, bleeding, infection and possible (but rare) even death. Because of this, non-invasive methods are necessary and they are to be examined whether they can be used for routine assessment of liver cirrhosis.
The most frequently used non-invasive methods to diagnose compensated cirrhosis are serum laboratory tests and ultrasound (US) or MRI-guided elastography, but they have their drawbacks. Therefore, morphometric analyses are also evaluated such as liver volume ratios, splenic volume, or subjective assessment of LSN on US, CT, and MRI. None of these mentioned are proven to be adequate enough to replace the gold standard. Only severe surface nodularity in the setting of chronic liver disease strongly suggests cirrhosis and can warrant a biopsy.
The author (A.D.S.) developed a semi-automated post-processing software able to quantify LSN on CT or MRI-images (Fig. 1). The hypothesis was that with this software LSN could reproducibly be quantified on routine CT-images, allowing accurate diagnosis and staging of the severity of HCV-induced cirrhosis. At the moment of the study, there were no known objective quantitative methods to determine LSN on routine CT imaging.
The study group consisted of 94 patients of which 24 patients with a healthy liver and 70 with a spectrum of hepatitis C chronic liver disease (HCV CLD). HCV is the leading cause of cirrhosis and hepatocellular carcinoma in the US and it affects 200 million people worldwide. Its estimated that 10 – 20% of patients with HCV will develop liver cirrhosis and 1 - 5% will develop HCC within 20-30 years (2).
The authors evaluated the accuracy, reproducibility, and intra- and interobserver variance of this semi-automated LSN-measurement for non-enhanced and enhanced (portal venous phase), and thin and thick-section CT-images for both acquisitions. The comparison was made with splenic volumes, LLS-to-TLV ratios (*), and total liver volume (TLV) for the different stages of CLD. (*) ratio of left lateral segment (LLS) to total liver volume (TLV).
The accuracy of the LSN score for differentiating cirrhotic from non-cirrhotic livers was high and consistently higher compared to splenic volume and LLS/TLV (Fig 2). The sensitivity of LSN was higher than splenic volume and LLS-to-TLV ratios and had an equal specificity compared to LLS-to-TLV ratios.
Furthermore, only LSN scores were higher for F4 decompensated versus compensated cirrhosis, suggesting an increase of LSN in size and heterogeneity with increasing severity of HCV cirrhosis.
This accuracy is comparable to the accuracy of liver stiffness measurements by US or MR elastography. Using the dedicated software, LSN scoring obtained a high reproducibility across different section thicknesses, with or without IV contrast. This may serve as proof that it can be reliably used on different types of CT acquisitions.
Intra- and interobserver agreement was very good with an intraclass correlation coefficient of 0.963 and 0.899, respectively.
LSN quantification was also less time consuming (median total time 1.9 min) than measuring splenic and liver volumes or calculating the LLS-to-TLV ratios (10 – 25 min).
Precirrhotic fibrosis was not investigated in this study. Pickhardt et al. investigated if this LSN scoring tool allows an accurate staging of hepatic fibrosis. They found accurate staging is possible of both significant (≥ F2) and advanced (≥ F3) levels of hepatic fibrosis. These stages are emerging as important clinical indicators that may influence management decisions. In addition, the diagnostic performance shows to be favourable in comparison to US and MRI elastography (3).
A. D. Smith et al. did show in another study of patients with cirrhosis from a variety of causes, that there is a direct linear correlation between the LSN score and the clinical stage of cirrhosis. Moreover, the LSN score proved to be an independent predictor of cirrhosis decompensation and death (4). They suggest LSN could be a complementary tool in combination with the well-known MELD-score (Model End-stage Liver Disease) in evaluating cirrhosis from different causes.
We can conclude that LSN quantifying is a promising tool to evaluate different stages of liver cirrhosis and even precirrhotic fibrosis. The main advantages are its reproducibility, time efficiency and ability to be retrospectively applied on routine CT-images.
1. Heidelbaugh, Joel J., and Michael Bruderly. "Cirrhosis and chronic liver failure: part I. Diagnosis and evaluation." Am Fam Physician 74.5 (2006): 756-62.
2. Sebastiani, Giada, Konstantinos Gkouvatsos, and Kostas Pantopoulos. "Chronic hepatitis C and liver fibrosis." World journal of gastroenterology: WJG 20.32 (2014): 11033.
3. Pickhardt, Perry J., et al. "Accuracy of Liver Surface Nodularity Quantification on MDCT as a Non-invasive Biomarker for Staging Hepatic Fibrosis." American Journal of Roentgenology 207.6 (2016): 1194-1199.
4. Smith, Andrew D., et al. "Liver Surface Nodularity Score Allows Prediction of Cirrhosis Decompensation and Death." Radiology (2016): 160799.
Dr. Cedric Bohyn is a second year resident under the University of Leuven training scheme, currently working at the AZ Delta Hospital in Roeselare (Belgium). He has interest in a wide variety of radiologic topics, yet with some predilection for abdominal radiology. He completed his undergraduate medical degree at the University of Leuven in 2015. Appointed secretary of the Young Radiologist Section (YRS – Belgian resident association as part of the Belgian Society of Radiology), he fully supports and promotes the training of residents. Moreover, he actively participated in organizing the BSR's annual conference of 2016 where he also presented various topics as he did at JFR 2016. As a junior resident, he aspires to continuously learn and strengthen his knowledge on the challenging radiological matter.
Comments may be sent directly to Dr. Cedric Bohyn.
Reducing Artifacts during Arterial Phase of Gadoxetate Disodium-enhanced MR Imaging: Dilution Method versus Reduced Injection Rate
Kim YK, Lin WC, Sung K, Raman SS, Margolis D, Lim Y, Gu S, Lu D. Radiology, 2016, Ahead of Print, 10.1148/radiol.2016160241
Dr. Domenico De Santis, "Sapienza" - University of Rome, Department of Radiological Sciences, Oncology and Pathology, Italy
Gadolinium ethoxybenzyl dimeglumine (Gd-EOB-DTPA), labeled as Primovist in Europe and Japan and Eovist in the United States, is a liver-specific magnetic resonance (MR) contrast media characterized by a biliary excretion up to 50% in the normal liver. After it is injected intravenously, Gd-EOB-DTPA distributes throughout the vascular and extravascular spaces during the arterial, portal-venous and delayed phases. The key feature of this contrast media is its ability to be progressively taken up by the hepatocytes via the OATP1B1 and OATP1B3 transporters and excreted into the biliary duct via the MRP2 transporter during the hepatobiliary phase. This phase is typically acquired 20 minutes after the intravenous injection .
These aforementioned features allow Gd-EOB-DTPA to have characteristics of a traditional gadolinium chelate contrast agent during the dynamic phases and to provide specific functional liver information, improving the detection of liver lesions and diffuse liver diseases, specifically liver metastases, hepatocellular carcinomas and liver cirrhosis [2, 3].
An increasing number of institutions are adopting Gd-EOB-DTPA in clinical practice to evaluate patients with known or suspected focal liver disease. However, every radiologist who has performed MR examinations with Gd-EOB-DTPA has experienced the presence of ghosting artifacts during the arterial phase (AP), resulting in suboptimal or non-diagnostic AP. This issue, also documented in a number of publications [4, 5], should not be underestimated since the AP is of paramount importance in the characterization of liver lesions [6, 7].
Different strategies have been adopted to reduce ghosting artifacts, such as diluting the contrast media or performing a slow-rate injection. However, no unanimous consent regarding the optimal injection strategy has been obtained thus far.
The authors of this manuscript performed a retrospective study including 318 consecutive patients (mean age 62.7 years, 205 men) who underwent clinically indicated Gd-EOB-DTPA MRI examination. These patients were placed into two comparable cohorts:
- Dilution cohort ([Gd-EOB-DTPA was diluted 1:1 with saline and injected at a rate of 2.0 mL/sec] n= 159);
- Slow injection cohort ([Gd-EOB-DTPA was not diluted and was injected at a rate of 1.0 mL/sec] n= 159).
The volume of Gd-EOB-DTPA injected was either 10 mL and 20 mL, the latter dose was used in patients who weighed more than 90.7 kg (200 lbs). In order to control potential bias and to assess intra-individual analysis, a sub-cohort of patients requiring imaging follow-up underwent MR examination with both methods. MR images were acquired with either 1.5 or 3 Tesla scanners. A fat-suppressed T1-weighted three-dimensional spoiled gradient echo sequence was performed in breath holding during the AP and the image analysis was subjectively performed by means of a 5-point scale by two independent readers blinded to the injection protocol (Table 1).
In the patient-based analysis, the dilution cohort had a significantly lower mean artifact score compared to the slow injection cohort (1.46 VS 1.95; P <0.001) and was characterized by less frequent severe ghosting artifacts (3.8% VS 15.1%, P <0.001) (Fig 1).
In the image-based analysis, the estimated log odds of mean and severe artifact score would decrease by 0.605 and 1.780, respectively, with the dilution method when compared with that attained with the slow injection method (all P <0.001).
In the sub-cohort of patients who underwent both injection protocols there were significant differences in the mean artifact score changes and frequency of severe artifact according to the order of the two injection methods within each patient (Fig 2).Concerning the relationship of artifacts with contrast media dose, a higher incidence of severe motion artifact was reported when using 20mL of Gd-EOB-DTPA as opposed to 10mL (both injected at a rate of 2 mL/sec). However, in a subsequent analysis of dilution versus slow injection methods for the frequency of severe artifact, the effect of contrast media volume was significant only in the slow injection group, where the severe artifacts were reported in 16.8% of cases with 10mL of Gd-EOB-DTPA and 36% of cases with 20mL of Gd-EOB-DTPA (P =0.030).With this study the authors demonstrated that a 50% contrast agent dilution method outperforms a 50% injection rate reduction in minimizing ghosting artifact on AP images associated with administration of Gd-EOB-DTPA. Therefore, the dilution of Gd-EOB-DTPA with saline represents the best method to reduce the ghost artifact in AP and achieve a diagnostic MR examination. Thus, to the best of our knowedge, this approach is highly advisable in every institution dealing with advanced liver imaging.
1. Leonhardt M, Keiser M, Oswald S, Kuhn J, Jia J, Grube M, et al. Hepatic uptake of the magnetic resonance imaging contrast agent Gd-EOB-DTPA: role of human organic anion transporters. Drug Metab Dispos. 2010;38:1024-8.
2. Reimer P, Schneider G, Schima W. Hepatobiliary contrast agents for contrast-enhanced MRI of the liver: properties, clinical development and applications. Eur Radiol. 2004;14:559-78.
3. Kanki A, Tamada T, Higaki A, Noda Y, Tanimoto D, Sato T, et al. Hepatic parenchymal enhancement at Gd-EOB-DTPA-enhanced MR imaging: correlation with morphological grading of severity in cirrhosis and chronic hepatitis. Magn Reson Imaging. 2012;30:356-60.
4. Davenport MS, Viglianti BL, Al-Hawary MM, Caoili EM, Kaza RK, Liu PS, et al. Comparison of acute transient dyspnea after intravenous administration of gadoxetate disodium and gadobenate dimeglumine: effect on arterial phase image quality. Radiology. 2013;266:452-61.
5. Pietryga JA, Burke LM, Marin D, Jaffe TA, Bashir MR. Respiratory motion artifact affecting hepatic arterial phase imaging with gadoxetate disodium: examination recovery with a multiple arterial phase acquisition. Radiology. 2014;271:426-34.
6. Cruite I, Tang A, Sirlin CB. Imaging-based diagnostic systems for hepatocellular carcinoma. AJR Am J Roentgenol. 2013;201:41-55.
7. Wald C, Russo MW, Heimbach JK, Hussain HK, Pomfret EA, Bruix J. New OPTN/UNOS policy for liver transplant allocation: standardization of liver imaging, diagnosis, classification, and reporting of hepatocellular carcinoma. Radiology. 2013;266:376-82.
Dr. Domenico De Santis is a fourth year Radiology Resident at "Sapienza" University of Rome, Italy. He is currently working as a research fellow at the Department of Radiology, Division of Cardiovascular Imaging at the Medical University of South Carolina, Charleston, USA. His clinical practice in Italy is primarily focused on oncological imaging with special interest in abdominal radiology-specifically liver imaging and virtual colonography-under the mentorship of Prof. Andrea Laghi. He has given scientific presentations at many international radiology meetings and he has his work has been publishing in several radiological journals.
Comments may be sent directly to Dr. De Santis.
Ureteral stones: Implementation
of a Reduced-Dose CT Protocol in Patients in the Emergency Department with Moderate to High Likelihood of Calculi on the Basis of STONE Score
Christopher L. Moore, MD; Brock Daniels, MD; Dinesh Singh, MD; Seth Luty, MS; Gowthaman Gunabushanam, MD; Monica Ghita, PhD; Annette Molinaro, PhD; Cary P. Gross, MD. Radiology. 2016 Sep; 280(3)
Dr. Raquel Madaleno, Resident, Medical Imaging Department, University Hospital of Coimbra, Portugal
Prof. Dr. Luís Curvo Semedo, Assistant Professor of Radiology, Faculty of Medicine and Medical Imaging Department, University Hospital of Coimbra, Portugal
The main goal of this prospective study by Moore, C. et al (published in last September issue of Radiology) was to determine the sensitivity of reduced-dose CT in the diagnosis of ureteral stones in moderate to high risk patients presenting to the emergency department, requiring urologic intervention.
Renal stones have an incidence of about 0,1-0,4% per year in the United States and in Europe. They usually reoccur, nearly in 75% of the cases during the following 20 years (1).
CT is a method with high diagnostic accuracy in the detection of ureteral stones. The American College of Radiology Appropriateness Criteria emphasizes that, when CT is performed for stone disease, the reduced-dose CT protocols should be preferred, usually yielding an effective dose of about 3mSv. This is of special interest since, frequently, many imaging revaluations are needed (2). However, low-dose protocols are poorly implemented due to the concern of reducing the accuracy in detecting both ureteral stones and alternative diagnoses, which is one of the advantages of CT compared with other imaging techniques (1). In this study the authors used a reduced-dose CT protocol which was the subject of a previous publication, reaching an average radiation dose reduction of 88%.
The patients were stratified based on STONE score in high (90% likelihood of ureteral stone), moderate (50% likelihood of ureteral stone) and low (<10% likelihood of ureteral stone) risk groups. The STONE score uses five criteria (sex, timing, origin, nausea and erythrocytes) that showed to consistently predict the likelihood of ureteral stones in previous studies. Reduced-dose CT was initially performed in 165 patients, including all high risk patients and 73% of patients with moderate risk. After that acquisition, a standard-dose CT was performed in 32% of the patients, when the radiologist determined that image quality was limiting the diagnostic accuracy. This value was slightly higher than expected by the authors, probably due to the radiologist discomfort with low-dose images and the decrease in diagnostic confidence. The reduced-dose CT images from patients who were rescanned with standard-dose CT were blindly reread, resulting in 30 true-positive and 18 true-negative findings for ureteral stone, and five false-negative findings for ureteral stone, without any false-positive findings, resulting in a sensitivity of 86% and a specificity of 100%. The false-negative cases represented five small stones that were expelled without need of intervention. Previous studies have shown that the reduced-dose CT is sensitive enough to detect large stones (> 5 mm) that may require urologic intervention, while it possesses a lower sensitivity in detecting small stones that usually do not require interventional procedures (2).
Of all patients that were studied with reduced-dose CT alone, 25 procedures were necessary, namely 24 urologic procedures (lithotripsy, stent, surgical stone extraction or nephrostomy), and one non-urologic surgery for acute appendicitis.The clinical conditions that required these procedures were all correctly identified with reduced-dose CT, and therefore the study reached a sensitivity of 100% to detect abnormalities that required intervention. However, there was one case of mild diverticulitis identified on rescan with standard-dose CT only, that did not require surgical intervention.
The results of this paper are similar to previous studies that achieved high sensitivity and specificity for diagnosing urolithiasis (3,4).The reduced-dose CT protocols were also evaluated in the management of acute appendicitis, with similar results comparably to standard-dose CT with regard to negative appendectomy rates (5). It would be interesting to see more studies about low-dose CT in the evaluation of the most relevant differential diagnoses for acute flank pain, namely cholecystolithiasis, diverticulitis, pelvic tumours and aortic aneurysms.
In conclusion, this paper shows that reduced-dose CT protocols has a high diagnostic accuracy in the detection of ureteral stones. However, definition of an adequate level of noise that allows both the detection of urolithiasis and alternative diagnoses should be defined in order to allow a widespread implementation, specially in the emergency department.
1. Niemann, T., Kollmann, T., Bongartz, G. Diagnostic Performance of Low-Dose CT for the Detection of Urolithiasis: A Meta-Analysis. American Journal of Roentgenology 2008 191:2, 396-401
2. Drake, T., Jain, N., Bryant, T., Wilson, I., Somani, B. Should low-dose computed tomography kidneys, ureter and bladder be the new investigation of choice in suspected renal colic?: A systematic review. Indian Journal of Urology 2014 Apr-Jun; 30(2): 137–143.
3. Tack, D., Sourtzis, S., Delpierre, I., Maertelaer, V., Gevenois, P. Low-Dose Unenhanced Multidetector CT of Patients with Suspected Renal Colic. American Journal of Roentgenology 2003 180:2, 305-311.
4. Poletti, P., Platon, A., Rutschmann, O., Schmidlin, F., Iselin, C., Becker, C. Low-Dose Versus Standard-Dose CT Protocol in Patients with Clinically Suspected Renal Colic. American Journal of Roentgenology 2007 188:4, 927-933.
5. Kim, K., Kim, Y., Kim, S., Kim, S., Lee, Y., Kim, K., et al. Low-Dose Abdominal CT for Evaluating Suspected Appendicitis. The New England Journal of Medicine 2012; 366:1596-160.
Dr. Raquel Madaleno is a third year resident working at the Medical Imaging Department, University Hospital of Coimbra, Portugal. She completed her undergraduate medical degree at the NOVA Medical School of the New University of Lisbon in 2013. She has her main interest in abdominal radiology, with particular regard to liver and bowel imaging.
Comments may be sent to Central ESGAR Office at email@example.com
Early peribilary hyperenhancement on MRI in patients with Primary Sclerosing Cholangitis: significance and association with the Mayo Risk Score.
Ni Mhuircheartaigh JM, Lee KS, Curry MP, Pedrosa I, Mortele KJ. Abdom Radiol (NY). 2017 Jan;42(1):152-158.
Dr. Christopher Tang, Radiology Registrar, Guy’s and St Thomas’ NHS FT, London/GB
Dr. Sofia Gourtsoyianni, Consultant Radiologist, Guy’s and St Thomas’ NHS FT, London/GB
This paper published by Mhuircheartaigh et al in Abdominal Radiology focused on the use of contrast enhanced MRI in patients with Primary Sclerosing Cholangitis (PSC). Two main aims were evaluated: (1) Whether there is any relationship between peribiliary hyperenhancement on MRI and the Mayo risk score, and (2) Whether peribiliary hyperenhancement on MRI correlates with overall clinical outcome.
MRI is well established in the diagnosis of PSC, however there has been limited evidence characterising its role in terms of predicting disease severity and outcome. The Mayo risk score is a validated clinical model calculating estimated survival points for PSC patients, based on patient age, history of variceal bleeding, and blood markers including bilirubin, albumin and aspartate aminotransferase (AST).
This study was performed retrospectively, including all patients with known or suspected PSC who underwent contrast-enhanced MRI of their liver over a 4 year period. As part of the MRI protocol, a gadolinium based contrast was used, with post-contrast images obtained during the arterial, portal venous (45s after the arterial phase), and delayed venous phase (90s after the arterial phase). Two abdominal imaging radiologists independently reviewed the MRI studies, evaluating for the absence or presence of peribiliary hyperenhancement on each phase of imaging. If hyperenhancement was present, then it was classified as localised, segmental or diffuse.
A total of 62 patients were identified, who had their diagnosis of PSC confirmed by a combination of clinical assessment, ERCP and MRCP findings and liver biopsy (in a minority). These patients were initially stratified into low (n=41), medium (n=14) and high (n=7) risk groups based on their Mayo risk score.
The interobserver agreement for peribiliary hyperenhancement was good (k=0.919), with a consensus reached for those cases where there was initial disagreement. Accounting for this, the authors demonstrated a significant difference in the prevalence of arterial peribiliary hyperenhancement between the intermediate and low risk groups (p<0.05), with a difference in prevalence of arterial peribiliary hyperenhancement approaching significance between the high and low risk groups (p=0.059). No significant association was noted with later phase enhancement. Furthermore, there was a significant association between the extent of peribiliary hyperenhancement with the Mayo risk group (p<0.01), with more diffuse enhancement associated with a high Mayo risk.
A time to event analysis was also performed based on the presence of arterial peribiliary hyperenhancement, using a combined end point of death or liver transplantation. This demonstrated a statistically significant difference in survival times between patients who exhibited arterial peribiliary hyperenhancement and those who did not.
The study finding of a statistically significant association between arterial peribiliary hyperenhancement and higher Mayo risk scores and thus poorer prognosis is interesting, since the role of MRI in monitoring PSC is currently unclear. Although no causality was demonstrated, the authors postulate that arterial peribiliary hyperenhancement is a reflection of ongoing acute inflammation and cholangitis, which would intuitively suggest a worse prognosis. PSC is a slowly progressive disease, and current management relies on continual monitoring of disease progression. Although the Mayo risk score already provides a way to prognosticate PSC patients, one potential advantage of using MRI to assess for arterial peribiliary hyperenhancement is the ability to assess for disease heterogeneity within an individual and potentially monitor treatment response.
The authors note some study limitations. Firstly the study only demonstrated an association of arterial peribiliary hyperenhancement with the Mayo score, which is a surrogate marker of progression, rather than a true assessment of outcome. Secondly, the study cohort only included a relatively small number of patients who had high Mayo risk scores. Finally, the study only evaluated for peribiliary hyperenhancement, and other clinical features of PSC such as biliary strictures and cirrhosis were not assessed. The role of these other factors could also be evaluated in future research. Correlation with T2 weighted signal intensity and/or DWI characteristics of peribiliary hyperenhancement areas might also be worth investigating in the future.
This is certainly an interesting study that highlights that arterial phase is of clinical value when assessing PSC patients with contrast enhanced liver MRI, and it is something that should be commented on.
1. Kim WR, Therneau TM, Wiesner RH, et al. (2000) A revised natural history model for primary sclerosing cholangitis. Mayo Clin Proc 75(7):688–694
2. Petrovic BD, Nikolaidis P, Hammond NA, et al. (2007) Correlation between findings on MRCP and gadolinium-enhanced MR of the liver and a survival model for primary sclerosing cholangitis. Dig Dis Sci 52(12):3499–3506
3. Ruiz A, Lemoinne S, Carrat F, et al. (2014) Radiologic course of primary sclerosing cholangitis: assessment by three-dimensional magnetic resonance cholangiography and predictive features of progression. Hepatology 59(1):242–250
Dr. Christopher Tang is a second year radiology registrar at Guy’s and St Thomas’ Hospital, London. He graduated from the University of Oxford before completing his undergraduate medical training with distinction at King’s College London. He currently has a broad range of interests within diagnostic radiology and has presented at international radiology and nuclear medicine conferences. Comments may be sent to Central ESGAR Office at firstname.lastname@example.org
Magnetic Resonance Elastography is as Accurate as Liver Biopsy for Liver Fibrosis Staging
Hiroyuki Morisaka, Utaroh Motosugi, Shintaro Ichikawa, Tadao Nakazawa, Tetsuo Kondo, Satoshi Funayama, Masanori Matsuda, Tomoaki Ichikawa, Hiroshi Onishi.
J Magn Reson Imaging 2017 Oct 14. doi: 10.1002/jmri.25868
Dr Nathania Bonanno, Higher Specialist Trainee, Mater Dei Hospital, Msida/MT
Dr Kelvin Cortis, Consultant Radiologist, Mater Dei Hospital, Msida/MT
The importance of diagnosing hepatic fibrosis at an early, potentially reversible, stage is that of preventing complications arising from progression to cirrhosis (including aggravated risk of having hepatocellular carcinoma and deranged liver function that may lead to liver failure), and also preventing the complications of portal hypertension (including ascites and variceal bleeding). This introductory concept set the tone for the study carried out by Morisaka et al., which has just been published in the September issue of the Journal of Magnetic Resonance Imaging (impact factor 3.083).
Percutaneous image-guided liver biopsy is an imperfect gold standard, with limitations that include sampling errors and intra/inter-observer variability. Various image-based methods have been employed for the non-invasive estimation of liver fibrosis, including T1 and T2 measurements, morphological assessment of hepatic architecture, contrast-enhancement, and elastography. Ultrasonography (US)-based elastography1 and magnetic resonance elastography (MRE)2 have already been well-validated for evaluating liver fibrosis. In fact, prior studies have shown that liver MRE has a high repeatability3-5 and has been cross-validated with biopsy and US-based elastography6,7.
The study conducted by Morisaka et al. is novel, in that the authors ventured beyond the boundaries of former studies and used resected liver specimens as reference standards for liver fibrosis. The authors did so with the aim of comparing the diagnostic accuracy of fibrosis staging by MRE and liver biopsy. This is in contrast to earlier studies wherein MRE could not be directly compared to liver biopsy because biopsy was used as a reference standard8-10.
The study population was retrospectively identified. In all, 200 patients who underwent preoperative MRE (using 2D liver MRE with gradient-echo sequence on a 1.5 or 3T scanner) and subsequent surgical liver resection were included in this study. Next, the patient cohort was distributed to two datasets, the preliminary set (n=80) and the validation set (n=120). Data from the former were used to estimate cut-off and distributions of liver stiffness values measured by MRE for each of the five liver fibrosis stages as determined by the METAVIR scoring system (F0-F4). In the remaining 120 patients – the study group – liver biopsy specimens were obtained from the resected liver tissues using a standard biopsy needle and then examined to compare the diagnostic accuracies of MRE- and liver biopsy-based fibrosis staging methods.
Two experienced abdominal radiologists, blinded to the histological results, independently measured the liver stiffness value on MRE. Two types of MRE-based liver fibrosis staging methods (threshold and Bayesian prediction method) were applied to the assembled data. Two pathologists, also blinded, evaluated all biopsy samples independently to stage liver fibrosis using surgically resected whole tissue specimens as the reference standard.
The results from the first radiologist and pathologist were used for the main analyses and that from the second observer was used for the assessment of inter-observer agreement.
For the analytic part of the study, the authors compared statistical accuracy for liver fibrosis staging (graded as significant fibrosis ≥F2, severe fibrosis ≥F3, and cirrhosis F4) between liver biopsy and the two MRE-based methods using a modified McNemar’s test (which is, simply put, a test to determine whether there is statistical difference between two paired populations from which the samples are drawn).
The overall diagnostic accuracy of MRE marginally surpassed that of liver biopsy – 59.1% (71/120) and 51.6% (62/120), respectively. Diagnostic accuracies of MRE for significant fibrosis, severe fibrosis, and cirrhosis were all statistically equivalent to that of liver biopsy (p ≤ 0.017). The proportions of under- and over-diagnosis between liver biopsy and MRE were also statistically comparable. The proportion of precise staging, i.e., not over- and under-staging, was 50-60% overall for both MRE- and liver biopsy-based staging.
Morisaka et al. set out to prove that MRE can be an alternative to liver biopsy for fibrosis staging; they have successfully done so by demonstrating that the diagnostic accuracy of MRE-based methods for liver fibrosis staging is equivalent to that of liver biopsy.
This article is presently one of a kind and its results may reshape current practice –the need for liver biopsy will be alleviated and MRE can make its way to the forefront as the leading method of liver fibrosis staging. It offers a non-invasive, less-costly alternative to liver biopsy sampling for assessing fibrosis in patients with chronic liver disease.
The article is exceptionally-written, comprehensive, and certainly worth the read.
1. Castera L, Vergniol J, Foucher J, et al. Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C. Gastroenterology 2005;128: 343–350.
2. Venkatesh SK, Yin M, Ehman RL. Magnetic resonance elastography of liver: technique, analysis, and clinical applications. J Magn Reson Imaging 2013;37:544–555.
3. Hines CD, Bley TA, Lindstrom MJ, Reeder SB. Repeatability of magnetic resonance elastography for quantification of hepatic stiffness. J Magn Reson Imaging 2010;31:725–731.
4. Shire NJ, Yin M, Chen J, et al. Test-retest repeatability of MR elastography for noninvasive liver fibrosis assessment in hepatitis C. J Magn Reson Imaging 2011;34:947–955.
5. Venkatesh SK, Wang G, Teo LL, Ang BW. Magnetic resonance elastography of liver in healthy Asians: normal liver stiffness quantification and reproducibility assessment. J Magn Reson Imaging 2014;39:1–8.
6. Oudry J, Chen J, Glaser KJ, Miette V, Sandrin L, Ehman RL. Cross-validation of magnetic resonance elastography and ultrasound-based transient elastography: a preliminary phantom study. J Magn Reson Imaging 2009;30:1145–1150.
7. Motosugi U, Ichikawa T, Amemiya F, et al. Cross-validation of MR elastography and ultrasound transient elastography in liver stiffness measurement: discrepancy in the results of cirrhotic liver. J Magn Reson Imaging 2012;35:607–610.
8. Venkatesh SK, Wang G, Lim SG, Wee A. Magnetic resonance elastography for the detection and staging of liver fibrosis in chronic hepatitis B. Eur Radiol 2014;24:70–78.
9. Batheja M, Vargas H, Silva AM, et al. Magnetic resonance elastography (MRE) in assessing hepatic fibrosis: performance in a cohort of patients with histological data. Abdom Imaging 2015;40:760–765.
10. Yin M, Glaser KJ, Talwalkar JA, Chen J, Manduca A, Ehman RL. Hepatic MR elastography: clinical performance in a series of 1377 consecutive examinations. Radiology 2015:142141.
Dr. Nathania Bonanno is a third year radiology resident at Mater Dei Hospital, Malta. She completed her undergraduate medical degree at the University of Malta in 2011. Her main interests are in diagnostic and interventional abdominal and pelvic radiology, with special regard to oncological imaging. She has presented multiple scientific studies at numerous international and national radiology conferences.
Comments are to be sent directly to email@example.com or firstname.lastname@example.org.
McInnes MD, Hibbert RM, Inácio JR, Schieda N. Focal Nodular Hyperplasia and Hepatocellular Adenoma: Accuracy of Gadoxetic Acid-enhanced MR Imaging-A Systematic Review. Radiology. 2015 Nov; 277(2):413-423.
Dr. Annalisa Mantarro (Radiology Resident, Pisa University Hospital, Pisa/IT)
Prof. Emanuele Neri (Associate Professor of Radiology, Pisa University Hospital, Pisa/IT)
The purposes of this systematic review, published in Radiology by McInnes in November 2015, were: 1) to assess the diagnostic accuracy of hepatobiliary phase (HBP) in gadoxetic acid–enhanced magnetic resonance imaging (MRI) of the liver for the diagnosis of focal nodular hyperplasia (FNH) versus hepatocellular adenoma (HCA); 2) to identify the rate of reported iso- or hyperintense HCAs and hypointense FNHs in HBP.
Both FNHs and HCAs are benign hepatic neoplasms, which affect similar adult population with overlapped features (such as hypervascularity on enhanced dynamic study) at MR examination. On this ground, accurate imaging differentiation of these lesions is crucial, since the therapeutic management is very different: frequently FNHs are treated conservatively, while HCAs require resection due to its possible complications, such as haemorrhage or malignant degeneration. Based on current knowledge, the HBP of gadoxetic acid-enhanced MRI guides the differential diagnosis between these two hepatic entities with high diagnostic accuracy: FNHs are typically iso/hyperintense owing to abnormal biliary ductules; while HCAs are commonly hypointense, for the lack of biliary ductules1,2,3.
However, recent studies reported that inflammatory HCAs represent more than half of all HCAs, showing higher rate of iso- or hyperintensity at HBP4.
This systematic review was written according to PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), and the Cochrane Handbook of Diagnostic Test Accuracy Reviews. The inclusion criteria are summarized in the Table 1.
The literature search yielded 1286 literature citations. After the review of all records, 61 articles were retrieved in full-text for further evaluation and a total of 6 studies (309 patients; 164 with HCA, 233 with FNH) fulfilled the inclusion criteria for the diagnostic accuracy assessment (primary outcome). Moreover, a total of 12 case series and case reports were included, since they reported either the rate of iso- or hyperintense HCAs or hypointense FNHs in the HBP (secondary outcomes, Figure 1).
The sensitivity in FNH diagnosis based on HBP was high, ranging from 0.91 to 1.00 (lower margin of the 95% confidence interval, CI 0.77). The specificity also was generally high, ranging from 0.87 to 1.00 (lower margin of the 95% CI 0.54, Figure 2). Of note, specificity was lowest among studies in which molecular subtyping of HCA was performed. The rate of iso- or hyperintensity of HCA in HBP ranged considerably from 0% to 70%, occurring more frequently in the inflammatory subtype; while the percentage of hypointense FNHs in HBP were 0%-23% (Figure 3).
This study pointed out the high diagnostic accuracy of gadoxetic acid–enhanced MRI in differentiating HCAs from FNHs. Among the included studies for the diagnostic accuracy evaluation, it is noteworthy that only one study classified HCA subtypes with molecular imaging, reporting them in a minority of patients (29/71)5, and thus producing the lowest specificity rate (87%; 95% CI 77-94). On the basis of these findings, among the studies in which molecular subtyping was not performed, the detected higher specificity could be the result of inflammatory HCA misclassification (iso- or hyperintense in HBP) as telangectatic FNH. The lack of HCA subtyping potentially produced fewer false-positive results, resulting in overestimation of specificity. This hypothesis was supported by data of the included case series, that provided molecular subtyping and a much higher rate of iso- or hyperintense HCAs in HBP. In this respect, among the included studies for diagnostic accuracy assessment the percentage of iso- or hyperintense HCAs in HBP was much lower (range 0%-13%) than the rate reported in case series (range 9%-70%).
This study further strengthens the importance of gadoxetic acid–enhanced MRI with liver-specific contrast agents for HCA/FNH differentiation. Nevertheless, additional large studies using molecular imaging are needed to both correctly identify inflammatory HCA and determine the role of HBP in predicting HCA subtype6.
1. Grazioli L, Bondioni MP, Haradome H et al (2012). Hepatocellular adenoma and focal nodular hyperplasia: value of gadoxetic acid-enhanced MR imaging in differential diagnosis. Radiology 262:520–529.
2. Neri E, Bali MA, Ba-Ssalamah A et al (2015). ESGAR consensus statement on liver MR imaging and clinical use of liver-specific contrast agents. Eur Radiol [Epub ahead of print].
3. Bieze M, van den Esschert JW, Nio CY et al (2012) Diagnostic accuracy of MRI in differentiating hepatocellular adenoma from focal nodular hyperplasia: prospective study of the additional value of gadoxetate disodium. AJR Am J Roentgenol 199:26–34.
4. Shanbhogue AK, Prasad SR, Takahashi N et al (2011). Recent advances in cytogenetics and molecular biology of adult hepatocellular tumors: implications for imaging and management. Radiology 258:673–693.
5. Grieser C, Steffen IG, Kramme IB et al (2014). Gadoxetic acid enhanced MRI for differenti- ation of FNH and HCA: a single centre expe- rience. Eur Radiol 24:1339–1348.
6. Merkle EM1, Zech CJ, Bartolozzi C et al (2015). Consensus report from the 7th International Forum for Liver Magnetic Resonance Imaging. Eur Radiol [Epub ahead of print].
Additional educational material:
EURORAD Case No: 11885 - Inflammatory hepatocellular adenoma - CT and MRI findings
Ramos Andrade D, Costa Y, Curvo Semedo L et al.
ESGAR 2015: SS 14.09 - Focal nodular hyperplasia versus inflammatory adenoma: clues for a confident differential diagnosis during MR imaging with a hepatobiliary (Gd-EOB-DTPA) contrast agent.
Battaglia V, Turturici L, Mantarro A et al.
ESGAR 2015: EE-163 - Hepatic adenoma: pictorial review of MRI findings and correlation with new molecular-pathological classification
Ciresa M, De Gaetano AM, Guerra A et al.
Dr. Annalisa Mantarrois a final year Resident at University of Pisa, in Italy. Her major field of interest is abdominal radiology, with particular regard to MR liver imaging and CT colonography. She has published in European Journal of Radiology, British Journal of Radiology, Abdominal Imaging, World Journal of Radiology, and Medical Radiology. Has been presenter of scientific papers at ESGAR, ECR, RSNA and SIRM meetings.
Comments may be sent directly to Dr. Mantarro.
Raghavan K, Jeffrey RB, Patel BN, DiMaio MA, Willmann JK, Olcott EW. MDCT Diagnosis of Perineural Invasion Involving the Celiac Plexus in Intrahepatic Cholangiocarcinoma: Preliminary Observations and Clinical Implications. AJR. 2015; 205:578-584.
Ruben Vandenbulcke – Resident, Department of Radiology, AZ Delta Hospital Roeselare & University Hopitals Leuven, Belgium
Philippe Lefere – Department of Radiology, AZ Delta Hospital Roeselare, Belgium
The purpose of this retrospective study, published in the American Journal of Roentgenology in December 2015 by Raghavan et al., was to test if soft-tissue infiltration along the celiac plexus and delayed enhancement exceeding two-thirds of the tumor area on preoperative Multi Detector Computed Tomography (MDCT) correlate with histologic evidence of perineural invasion in resected intrahepatic cholangiocarcinomas. Both conditions could possibly indicate irresectability of these malignant intrahepatic lesions.
Intrahepatic cholangiocarcinoma (ICC) is the second cause of primary liver cancer after hepatocellular carcinoma, representing 10-20 % of all primary malignant liver tumors. ICCs have an aggressive tumor biology with 5-year survival rates of 5-10% for unresectable disease and 20-35% for patients where a curative treatment is chosen with radical surgical resection.1 These rates are indicating an unmet need for multimodal treatment strategies to improve current survival and recurrence-free survival rates.
Twenty patients who underwent resection for intrahepatic cholangiocarcinoma were analyzed in this single centre retrospective study. Preoperative MDCT image sets were reviewed by two radiologists for perineural invasion involving the celiac plexus. Perineural invasion was diagnosed when contiguous soft-tissue infiltration was noted extending from the intrahepatic tumor directly along the extrahepatic perineural pathways to ultimately involve the fat planes around the celiac artery. The two known extrahepatic pathways include the neural plexus along the common hepatic artery within the hepatoduodenal ligament for right liver lobe tumors and the neural plexus along the left gastric artery within the gastrohepatic ligament for left liver lobe tumors (Figure 1). Also tumor size and delayed enhancement of tumor volume were noted.
Each resected intrahepatic cholangiocarcinoma specimen was histologically examined with perineural invasion defined as presence of neoplastic cells within the epineurium, perineurium or endoneurial space.
Preoperative MDCT showed infiltration along the celiac artery in 6 out of 20 patients with in 5 out of these 6 cases histologic examination revealing intratumoral perineural invasion. In this small group, soft-tissue infiltration along the celiac artery on preoperative MDCT was significantly associated with histologic evidence of perineural invasion (Table 1). No significant association was found on perineural infiltration and tumor size or delayed enhancement more than two-thirds of tumor area.
Despite the small population size, this is the first study comparing histologic findings of perineural invasion with MDCT appearance of soft-tissue infiltration along the perineural celiac axis in the setting of intrahepatic cholangiocarcinomas.
Only few patients with intrahepatic cholangiocarcinoma present with resectable disease at the time of presentation because of the aggressive behavior of these tumors. Resectability of intrahepatic cholangiocarcinoma is defined as the ability to resect tumor to negative margins while preserving adequate functioning liver. Patients demonstrating intrahepatic metastases, visceral peritoneum perforation, macrovascular or periductal invasion, lymphatic spread and extrahepatic metastases should not undergo resection because of the poor recurrence-free survival.2,3
In similarity to pancreatic adenocarcinoma where perineural invasion is associated with a poor prognosis, perineural invasion in intrahepatic cholangiocarcinoma is a major factor contributing to the high incidence of local recurrence after resection with curative intent.3,4 This finding on MDCT is a negative prognostic factor and a contraindication for major hepatic resection with curative intent due to distant extrahepatic perineural and lymphovascular tumor spread.4,5
The high incidence of recurrence is specifically associated with this perineural en lymphovascular invasion, highlighting the need for more effective adjuvant therapies after radical tumor resection with curative intent.5
Given the relatively poor response to systemic chemotherapy (gemcitabine and cisplatin) for unresectable cholangiocarcinoma, local transarterial therapies are developed such as transarterial chemoembolization (TACE) and selective internal radiotherapy (SIRT). These therapies are showing anti-tumor effects with acceptable toxicities.1,2 Results with SIRT are more pronounced in patients with solitary tumors and absent extrahepatic tumor spread, which could be an effective downstaging method for secondary surgical treatment.6
More studies with larger sample size are needed to more extensively explore correlations between preoperative MDCT findings and the behavior of intrahepatic cholangiocarcinoma. MDCT diagnosis of perineural invasion of the celiac plexus may assist in determination of prognosis and treatment planning.
1. Mavros MN, Economopoulos KP, Alexiou VG, Pawlik TM. Treatment and prognosis for patients with intrahepatic cholangiocarcinoma: systematic review and meta-analysis. JAMA Surg. 2014; 149:565-574.
2. Bridgewater J, Galle PR, Khan SA, et al.: Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma. J Hepatol 2014; 60:1268–1289.
3. Shirai K, Ebata T, Oda K, et al. Perineural invasion is a prognostic factor in intrahepatic cholangiocarcinoma.World J Surg 2008; 32:2395–2402.
4. Deshmukh SD, Willmann JK, Jeffrey RB. Pathways of extrapancreatic perineural invasion by pancreatic adenocarcinoma: evaluation with 3D volume-rendered MDCT imaging. AJR 2010; 194:668–674.
5. Fisher SB, Patel SH, Kooby DA, et al. Lymphovascular and perineural invasion as selection criteria for adjuvant therapy in intrahepatic cholangiocarcinoma: a multi-institution analysis. HPB 2012; 14:514–522.
6. Mouli S, Memon K, Baker T, et al. Yttrium-90 radioembolization for intrahepatic cholangiocarcinoma: safety, response, and survival analysis. J Vasc Interv Radiol. 2013; 24:1227–1234.
Additional educational materials:
EURORAD Case No:1347 – Cholangiocarcinoma
Bizimi V, Kailidou E, Katsiva V, Douridas G, Tibishrani M.
ESGAR 2013: EE-007 – Multimodality assessment of Cholangiocarcinoma. A challenge for the radiologists.
Sanchez GA, Parrilla JS, Radosevic A, Pedrosa NR, Lopez JCA, Barrera MB.
Dr. Ruben Vandenbulcke is a second year resident working at the Department of Radiology at AZ Delta Hospital Roeselare, following the radiology training scheme at the University Hospitals Leuven. He completed his undergraduate medical degree at the Catholic University of Leuven in 2014. He has a main interest in abdominal radiology, with particular regard to interventional abdominal radiology.
Comments may be sent directly to Dr. Ruben Vandenbulcke.
Lee YJ, Lee JM, Lee JS et al. Hepatocellular Carcinoma: Diagnostic Performance of Multidetector CT and MR Imaging — A Systematic Review and Meta-Analysis. Radiology. 2015; 275: 97-109
Dr. Davide Bellini, "Sapienza" - University of Rome, Department of Radiological Sciences, Oncology and Pathology, Italy
Dr. Riccardo Ferrari, "Sapienza" - University of Rome, Department of Radiological Sciences, Oncology and Pathology, Italy
This paper published in Radiology by Lee et al in April 2015 (1) aims to provide evidence based advices about which imaging modality to prefer in the setting of hepatocellular carcinoma (HCC).
Early detection of HCC is extremely important given that the diagnosis of HCC in an early stage allows curative treatment strategies and improves 5-years survival rate by more than 50% (2). Due to the lack of large randomized controlled trial assessing the diagnostic accuracy of different imaging modalities for detection of HCC, the present paper provides the best level of evidence and should be considered the most clinically relevant article on this topic.
Authors performed a systematic review and meta-analysis of the literature published in the past decade (from January 2000 to December 2012) in the attempt to obtain updated diagnostic performance values of CT and MR imaging for detection of HCCs in patients affected by chronic liver disease, on per patient and per lesion basis. They also evaluated the influence of hepatobiliary contrast agents on diagnostic performance.
Methods for analysis and inclusion criteria were based on the recommendations established by the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA)(3). The Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2 tool)(4) was used to evaluate quality of included studies. Heterogeneity was quantified by using the I2, sub-group analysis and meta-regression analysis were used to evaluate factors that could affect heterogeneity.
Forty studies (six on CT, 22 on MR and 12 on both CT and MR imaging) were included in the quantitative analysis, evaluating 1135 patients and 1332 HCCs with CT, 2489 patients and 2320 HCCs with MR. The mean size of the HCCs was approximately 2 cm (ranging from 0.9 to 4.6 cm), CT scanner used was at least 16 row MDCT in most of the studies (11 of 18), 1.5-Tesla magnetic field and hepatobiliary contrast agents were used in most of the articles on MR.
As major result, authors suggest that MR imaging should be considered the imaging modality of choice for evaluating HCCs in patients with chronic liver disease due to the higher per-lesion sensitivity compared to CT (80%.vs 68%; P = .0023) (Figure 1). For HCC lesions smaller than 1 cm, sensitivity decrease by 40% (Se = 48 %) for MR and by 54% (Se = 31%) for CT.
No significant differences were found in cumulative values of Sensitivity and Specificity on per patient basis between MR and CT (CT: Se 88%, Sp 74-100%; MR: Se 94%, Sp 81-100%). Moreover, promising evidences of improved sensitivity using hepatobiliary contrast agent have been reported. In particular, the use of Gadoxetic acid -enhanced MR imaging showed significantly higher per lesion sensitivity than MR imaging performed with other contrast agents (87% vs 74%, P = .03). This result further strengthens the importance of gadoxetic acid–enhanced MR imaging in the evaluation of patients suspected to have HCC.
Two limitations of the study should be mentioned. Cumulative value of sensitivity could be overestimated due to the retrospective nature of studies included in the analysis. The heterogeneity observed among studies included for per-lesion analysis reduces the strength of results.
1. Lee YJ, Lee JM, Lee JS, et al. Hepatocellular carcinoma: diagnostic performance of multidetector CT and MR imaging-a systematic review and meta-analysis. Radiology. 2015;275(1):97-109.
2. Forner A, Llovet JM, Bruix J. Hepatocellular carcinoma. Lancet. 2012;379(9822):1245-55.
3. Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med. 2009;151(4):W65-94.
4. Whiting PF, Rutjes AW, Westwood ME, et al. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med. 2011;155(8):529-36.
Dr. Davide Bellini is a final year radiology resident on the “Sapienza, University of Rome” training scheme in Italy. He has a main interest in abdominal radiology, with particular regard to CT colonography. He has a vivid interest in Evidence Based Medicine, in particular meta-analysis and guidelines development. He has presented lectures and scientific talks at a number of international radiology meetings and has published in several radiological and gastroenterological journals.
Comments may be sent directly to Dr. Davide Bellini.
Huh J, Kim SY, Yeh BM, Lee SS, Kim KW, Wu EH, Wang ZJ, Zhao LQ, Chang WC.
Troubleshooting Arterial-Phase MR Images of Gadoxetate Disodium-Enhanced Liver
Korean J Radiol. 2015 Nov-Dec;16(6):1207-15. doi:10.3348/kjr.2015.16.6.1207. Epub 2015 Oct 26
Dr. Daniel Ramos Andrade, Resident, Medical Imaging Department, University Hospital of Coimbra, Portugal
Prof. Dr. Luís Curvo Semedo, Assistant Professor of Radiology, Faculty of Medicine and Medical Imaging Department, University Hospital of Coimbra, Portugal
Gadoxetate disodium is widely used nowadays for characterization of focal liver lesions, as well as for detection of liver metastases and hepatocellular carcinoma in cirrhotic patients, because of its combined properties of a conventional non-specific extracellular and a hepatocyte-specific contrast agent .
Unfortunately, arterial-phase images are sometimes of very poor quality due to artifacts and weak arterial enhancement.
The purpose of this review article, published by the Korean Journal of Radiology in late 2015 by Huh et al. was to identify these two challenges and to suggest possible solutions for overcoming them.
A review of the literature on this subject is very confounding because some authors believe degradation of arterial phase image quality is due to Gibbs phenomenon / ringing / truncation artifacts, related to rapid changes in the contrast concentration during the obtainment of the data in the center of the k-space [2,3,4], while others postulate that transient severe motion / respiratory motion artifact / acute transient dyspnoea is the main culprit [5,6]. It can be very difficult to distinguish both artifacts. Ringing artifacts usually manifest as duplicates of strongly enhanced vessels that are centered on the vessels and fade further away from the vessels, being typically confined to the abdomen, whereas motion artifacts appear as duplicates of all the abdominal organs and abdominal wall and typically extend both anteriorly and posteriorly to the abdomen .
This article ultimately concludes that transient motion is the main source of artifacts in the clinical practice and not the ringing artifacts. After this review was published, another study by Motosugi et al further added that severe artifacts in the arterial phase were mainly associated with breath-hold failure (28 of 33 patients with severe artifacts) .
It is believed that transient severe motion artifacts occur in about 10.7-18% of patients but the pathophysiology and causes remain elusive . While the risk factors are yet to be identified, this article states that we can attempt to decrease these artifacts by using a single-breath-hold multiple arterial-phase acquisition  or using motion-insensitive sequences like CAIPIRINHA VIBE and radial-VIBE.
 Campos JT, Sirlin CB, Choi JY. Focal hepatic lesions in Gd-EOB-DTPA enhanced MRI: the atlas. Insights Imaging. 2012 Oct;3(5):451-74. doi: 10.1007/s13244-012-0179-7. Epub 2012 Jun 15.
 Tanimoto A, Higuchi N, Ueno A. Reduction of ringing artifacts in the arterial phase of gadoxetic acid-enhanced dynamic MR imaging. Magn Reson Med Sci. 2012;11(2):91-7.
 Motosugi U, Ichikawa T, Sou H, Sano K, Ichikawa S, Tominaga L, Araki T. Dilution method of gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI). J Magn Reson Imaging. 2009 Oct;30(4):849-54. doi: 10.1002/jmri.21913.
 Haradome H, Grazioli L, Tsunoo M, Tinti R, Frittoli B, Gambarini S, Morone M, Motosugi U, Colagrande S. Can MR fluoroscopic triggering technique and slow rate injection provide appropriate arterial phase images with reducing artifacts on gadoxetic acid-DTPA (Gd-EOB-DTPA)-enhanced hepatic MR imaging? J Magn Reson Imaging. 2010 Aug;32(2):334-40. doi: 10.1002/jmri.22241.
 Davenport MS, Viglianti BL, Al-Hawary MM, Caoili EM, Kaza RK, Liu PS, Maturen KE, Chenevert TL, Hussain HK. Comparison of acute transient dyspnea after intravenous administration of gadoxetate disodium and gadobenate dimeglumine: effect on arterial phase image quality. Radiology. 2013 Feb;266(2):452-61. doi: 10.1148/radiol.12120826. Epub 2012 Nov 28.
 Ringe KI, Husarik DB, Sirlin CB, Merkle EM. Gadoxetate disodium-enhanced MRI of the liver: part 1, protocol optimization and lesion appearance in the noncirrhotic liver. AJR Am J Roentgenol. 2010 Jul;195(1):13-28. doi: 10.2214/AJR.10.4392.
 Bashir MR, Castelli P, Davenport MS, Larson D, Marin D, Hussain HK, Jaffe TA. Respiratory motion artifact affecting hepatic arterial phase MR imaging with gadoxetate disodium is more common in patients with a prior episode of arterial phase motion associated with gadoxetate disodium. Radiology. 2015 Jan;274(1):141-8. doi: 10.1148/radiol.14140386. Epub 2014 Aug 25.
 Motosugi U, Bannas P, Bookwalter CA, Sano K, Reeder SB. An Investigation of Transient Severe Motion Related to Gadoxetic Acid-enhanced MR Imaging. Radiology. 2015 Oct 16:150642. [Epub ahead of print]
 Kim SY, Park SH, Wu EH, Wang ZJ, Hope TA, Chang WC, Yeh BM. Transient respiratory motion artifact during arterial phase MRI with gadoxetate disodium: risk factor analyses. AJR Am J Roentgenol. 2015 Jun;204(6):1220-7. doi: 10.2214/AJR.14.13677.
 Pietryga JA, Burke LM, Marin D, Jaffe TA, Bashir MR. Respiratory motion artifact affecting hepatic arterial phase imaging with gadoxetate disodium: examination recovery with a multiple arterial phase acquisition. Radiology. 2014 May;271(2):426-34. doi: 10.1148/radiol.13131988. Epub 2014 Jan 21.
 Tamada T, Ito K, Sone T, Yamamoto A, Yoshida K, Kakuba K, Tanimoto D, Higashi H, Yamashita T. Dynamic contrast-enhanced magnetic resonance imaging of abdominal solid organ and major vessel: comparison of enhancement effect between Gd-EOB-DTPA and Gd-DTPA. J Magn Reson Imaging. 2009 Mar;29(3):636-40. doi: 10.1002/jmri.21689.
 Tamada T, Ito K, Yoshida K, Kanki A, Higaki A, Tanimoto D, Higashi H. Comparison of three different injection methods for arterial phase of Gd-EOB-DTPA enhanced MR imaging of the liver. Eur J Radiol. 2011 Dec;80(3):e284-8. doi: 10.1016/j.ejrad.2010.12.082. Epub 2011 Feb 5.
 Boll DT, Merkle EM. Imaging at higher magnetic fields: 3 T versus 1.5 T. Magn Reson Imaging Clin N Am. 2010 Aug;18(3):549-64, xi-xii. doi: 10.1016/j.mric.2010.08.008.
 An C, Park MS, Kim D, Kim YE, Chung WS, Rhee H, Kim MJ, Kim KW. Added value of subtraction imaging in detecting arterial enhancement in small (<3 cm) hepatic nodules on dynamic contrast-enhanced MRI in patients at high risk of hepatocellular carcinoma. Eur Radiol. 2013 Apr;23(4):924-30. doi: 10.1007/s00330-012-2685-x. Epub 2012 Nov 9.
In addition to these artifacts, arterial phase MR images with Gadoxetate Disodium are also suboptimal due to weak arterial enhancement . The standard injection dose and the content of gadolinium for this hepatocyte-specific contrast is half and a quarter, respectively, of the conventional extracellular agent dose. This shortens the enhancement duration of the contrast bolus and lowers the magnitude of the peak enhancement compared with extracellular contrast agents. This article reviewed three solutions for this problem, namely:
1- Decreasing the injection rate to 1ml/sec. By slowing the injection rate, the bolus is stretched and the enhancement peak is higher [4,12]
2- Increasing the amount of Gadoxetate Disodium. Increasing the amount of the contrast, as it is done in several centers with a fixed dose of 10mL, also prolongs the peak arterial perfusion time 
3- Diluting the Gadoxetate Disodium with saline. Dilution of Gadoxetate Disodium with saline has also been proposed as an option to stretch the contrast bolus, but the evidence is still very limited and there is a risk of contamination [3,12].
From the technical standpoint, the article also recommends four modalities:
1- A bolus detection method. It helps to achieve a precise timing for acquisition of arterial images. 
2- Multiple arterial phase image acquisition with a fixed delay. The best images can be chosen and the bad ones discarded. This option also helps avoiding transient severe motion. 
3- 3T imaging. Theoretically, 3T provides a two-fold increase in signal gain in signal-to-noise ratio and better lesion-to-liver contrast, although Gadoxetate Disodium enhanced liver MRI studies comparing 3T with 1,5T are lacking. 
4- Subtraction images. This technique is more beneficial for depicting arterial enhancement than visual comparison only. 
All of the challenges, causes and possible solutions for obtaining high-quality arterial-phase MR images with Gadoxetate Disodium are summarized in the table below.
In conclusion, this article is probably the most important review yet published regarding possible solutions for the poor image quality of arterial-phase MR images of Gadoxetate Disodium-enhanced examinations. Nevertheless, additional large studies are necessary so that, once and for all, a standard protocol for Gadoxetate-disodium administration can be adopted.
Comments may be sent directly to Dr. Daniel Ramos Andrade.
Additional educational material:
RANZCR-AOCR 2012 Poster No.: R-0206
Y. X. Kitzing, S. McCormack, B. Ng. Tips and pitfalls of liver imaging with gadoxetic acid: a pictorial review
ECR 2012 Poster No.: C-0824
S. Suzuki, T. Kobayashi, M. Ozaki, H. Evaluation of simultaneous saline injection methods in Gd-EOB-DTPA-enhanced magnetic resonance imaging for reducing truncation artifacts
RSNA 2014 Poster No.: GIE205 Jimi Huh, So Yeon Kim, Benjamin M. Yeh, Seung Soo Lee, Kyoung Won Kim, En-Haw Wu, Z. Jane Wang, Li-qin Zhao, Wei Chou Chang. Trouble Shooting for Arterial Phase Images of Gd-EOB-DTPA-enhanced Liver MR
ECR 2015 Poster No.: C-0046
J. Zhao, C.-M. Li, W. chen, L. Zhang, P. CAI, J. Wang; Chongqing/CN. Comparison of three different slow injection rates of Gd-EOB-DTPA using MR fluoroscopic triggering technique for arterial phase MR imaging of the liver
Nougaret S, Vargas HA, Lakhman Y, Sudre R, Do RK, Bibeau F, Azria D, Assenat E, Molinari N, Pierredon MA, Rouanet P, Guiu B. Intravoxel Incoherent Motion-derived Histogram Metrics for Assessment of Response after Combined Chemotherapy and Radiation Therapy in Rectal Cancer: Initial Experience and Comparison between Single-Section and Volumetric Analyses. Radiology 2016 Feb 26 [ePub ahead of print]. DOI: dx.doi.org/10.1148/radiol.2016150702
Dr. Andrea Delli Pizzi – Radiology Resident, Gabriele d’Annunzio University, Chieti/IT (currently at The Netherlands Cancer Institute for research internship)
Prof. Regina Beets-Tan – Radiologist (head of department of Radiology), the Netherlands Cancer Institute, Amsterdam/NL
In this paper published in Radiology in February 2016, Nougaret et al. assessed the diagnostic performance of intravoxel incoherent motion (IVIM) parameters and apparent diffusion coefficient (ADC) to assess response to chemoradiotherapy (CRT) in rectal cancer by means of histogram analysis.
Functional imaging for rectal cancer response evaluation is a hotly debated topic and in particular the use of diffusion-weighted imaging has received much attention over the last years. The growing interest for rectal tumor response evaluation is probably related to the upcoming concept of organ-preserving treatment for good or complete responders after CRT. In order to select patients for organ-preservation (i.e. local excision or ‘watchful waiting’) an accurate assessment of treatment response becomes crucial.
Apart from visual assessment of diffusion images, many studies have focused on quantitatively analyzing tumor diffusion by measuring the tumor ‘Apparent Diffusion Coefficient’ (ADC). However, reports so far have shown inconsistent results and several studies found no clear benefit in measuring tumor ADC values to assess treatment response.
Nougaret and colleagues postulate that these conflicting results may be attributed to technical differences between DWI sequences used in literature, but also to failure to distinguish perfusion effects from true diffusion with the typically applied mono-exponential fitting used to calculate ADCs as well as the inability to capture tumor heterogeneity when evaluating only mean ADC values. In order to overcome these issues the authors applied extensive b-value sampling (34 b values) and a bi-exponential curve fit analysis with the IVIM model combined with histogram analysis to study tumor heterogeneity. IVIM is a relatively novel approach that uses a bi-exponential function to analyze DWI-data. It takes into account two components of the diffusion signal decay curve, which are related to tissue perfusion and tissue diffusivity.1 This approach was recently applied in abdominal imaging to investigate other tumors such as hepatocellular carcinoma and pancreatic cancer.2,3 Currently the paper by Nougaret et al. is one of the few concerning IVIM application in rectal cancer and it is so far the only one assessing its diagnostic performance in treatment response evaluation. The study included 31 patients with rectal cancer who underwent MRI including DWI before and after chemoradiotherapy. ADC, perfusion-related diffusion fraction (f), slow diffusion coefficient (D), and fast diffusion coefficient (D*) were calculated and compared with histopathologic findings. For each parameter, histogram analysis was performed. The results of the study showed that none of the ADC and IVIM metrics could predict response prior to treatment. After CRT, IVIM-derived diffusion coefficient D as well as ADC increased significantly and their respective post-treatment values were significantly higher in good versus poor responders. Diagnostic performance of post-CRT D and ADC histogram metrics to predict a good response are shown in the table 3. Best results were obtained for median D values post-CRT (area under the curve of 0.98, sensitivity 94%, specificity 100%). Histogram metrics did not yield better results than median values for assessment of response. The authors therefore conclude that histogram analyses may not be required in everyday clinical practice.
The authors also found no benefit for the IVIM-derived f and D* parameters in assessing response. This is in line with previous reports that focused on IVIM for the assessment of response in liver tumors.3-5 Moreover in a study published in 2013, Bäuerle et al. used an IVIM approach to analyze two groups of rectal carcinoma patients (with and without chemoradiotherapy).6 In the group without CRT they showed a correlation between f and the postoperative histological vascular area fraction, but no significant correlation was found in the group after CRT. A reasonable explanation for these incongruent results is that D* value is affected by high uncertainty and poor reproducibility and f value is widely influenced by T2 relaxation times of blood and tissues. Hence, as described by Lemke et al., authors underline that a specific T2 correction may be essential for a correct interpretation of results.7 Moreover it would be interesting to see how IVIM-derived perfusion related parameters correlate with perfusion parameters derived from dynamic contrast enhanced (DCE) -MRI acquisitions. A recent study by Hötker et al. showed that both DWI-MRI and DCE-MRI parameters were significantly associated with the degree of tumor regression in the resected specimen.8 It would be interesting to see how IVIM-derived perfusion related parameters may fit into this picture. Further studies in larger patient groups are required to establish the correlation between DCE perfusion parameters, ADC and IVIM metrics and to draw definite conclusions regarding their potential (complementary) value in predicting response.
1. Koh DM, Collins DJ, Orton MR. Intravoxel incoherent motion in body diffusion-weighted MRI: reality and challenges. AJR Am J Roentgenol 201;196(6):1351–1361.
2. De Robertis R, Tinazzi Martini P, Demozzi E, Dal Corso F, Bassi C, Pederzoli P, D'Onofrio M. Diffusion weighted imaging of pancreatic cancer. World J Radiol. 2015 Oct 28;7(10):319-28.
3. Woo S, Lee JM, Yoon JH, Joo I, Han JK, Choi BI. Intravoxel incoherent motion diffusion-weighted MR imaging of hepatocellular carcinoma: correlation with enhancement degree and histologic grade. Radiology 2014;270(3):758–767.
4. Andreou A, Koh DM, Collins DJ, et al. Measurement reproducibility of perfusion fraction and pseudodiffusion coefficient derived by intravoxel incoherent motion diffusion-weighted MR imaging in normal liver and metastases. Eur Radiol 2013;23(2):428–434.
Additional educational material:
ESGAR 2015, Recommended Poster: Various kinds of neoplastic and non-neoplastic lesions in the rectal MRI encountered in the daily practice, J.-H. Yoon, S. Lee, S.H. Kim, Y. Lee, Y.-J. Lim, J.W. Ryu, H.-D. Kim; Busan/KR
ESGAR 2015, WS 26 - Rectal cancer: assessment of treatment respons, L. Curvo-Semedo (Coimbra, Portugal)
EURORAD Case Nr. Case 12099 - Ovarian metastases from colorectal cancer, Serpa, Sara; Silva, David; Amaral, Rui; Simões, Marta; Fernandes, Otília (2014, Sep 22)
D. Tsurumaru, M. Miyasaka, Y. Nishimuta et al. Differentiation of early gastric cancer with ulceration and resectable advanced gastric cancer using multiphasic dynamic multidetector CT. Eur Radiol. 2016; 26: 1330-1337.
Dr. Ruolei Chen (Radiology Registrar, Guy’s and St Thomas’ Hospitals, London, GB)
Dr. Sofia Gourtsoyianni (Consultant Radiologist, Guy’s and St Thomas’ Hospitals, London, GB)
This paper by D. Tsurumaru and colleagues was published in the European Radiology Journal in May 2016. The objectives were to (a) determine whether multiphasic dynamic multidetector CT (MDCT) can help differentiate early gastric cancer with ulceration (EGC-U) from advanced gastric cancer (AGC) and (b) to evaluate the diagnostic performance on differentiating these tumours.
Accurate differentiation of EGC-U from AGC is crucial: the deeper depth of tumour invasion of gastric cancer is associated with poorer survival rates , whilst treatment options for these are different. On endoscopy, EGC-U and AGC have similar appearances .
A retrospective study was performed for the period January 2006 to December 2012. A total of 16 patients with EGC-U with the ulcer stage of Ul-III or IV and 24 patients with AGC with the tumour stage of T2 to T4a were analysed. All these patients had pathologically confirmed gastric adenocarcinoma after gastrectomy, with the tumour being visible on both preoperative gastroscopy and contrast-enhanced MDCT.
A very meticulous imaging protocol has been adopted/proposed . Prior to CT imaging and after an overnight fast, each patient ingested an effervescent agent with water and had an injection of intramuscular Buscopan to suppress peristalsis. Images were obtained at 40s (arterial phase), 70s (portal phase) and 240s (delayed phase) after an infusion of intravenous contrast. Two radiologists independently reviewed the CT images on a workstation using virtual endoscopy. The lesion size (largest dimension using multiplanar reconstruction) and its attenuation value on each phase of contrast were recorded. Two endoscopists interpreted the endoscopic images independently and had to diagnose the lesion as EGC-U or AGC according to the Japanese Classification of Gastric Carcinoma .
The authors found that the mean lesion size was 35 mm for the EGC-Us and significantly larger for the AGCs at 45 mm (p=0.033). On MDCT analysis, the mean attenuation values of EGC-U cases were significantly lower than those of the AGC cases in both the arterial and portal phases (both p<0.0001). Delayed phase attenuation values were equivocal between the two groups (Table 1). Peak enhancement for EGC-U was in the delayed phase and for AGC was in the arterial phase.
Different cut-off values were used for each reader to assess diagnostic performance of arterial, portal venous and peak enhancement value, respectively.
An explanation for the increased enhancement demonstrated by AGC compared to EGC-U in the arterial and portal phases is related to gastric cancers showing neovascularity during the arterial to capillary phase in vivo [5, 6]. The peak enhancement of EGC-U in the delayed phase in this study may be due to EGC-U containing varying degrees of fibrous tissue associated with ulceration, similar to benign gastric ulcers.
It is interesting to note that this study found the endoscopic evaluation to have lower accuracy values (70.0 % and 72.5 %) in identifying EGC-U and AGC compared to portal venous phase MDCT (92.5 % and 90.0 %). However, this may be partially attributable to the endoscopists being only able to view selected images from the initial gastroscopy.
The authors note several study limitations. First, it is a retrospective study with a relatively small patient population. Second, their CT protocol did not include an unenhanced CT phase with possible greater accuracy for gastric cancer detection being achieved if this was available. Third, all the cases in their series were resectable gastric cancers and it is unclear whether the results would be applicable to non-resectable gastric cancers. However, even with these potential limitations, their findings suggest that the attenuation value measurements help differentiate EGC-U from AGC.
In conclusion, the finding that EGC-U had significantly lower attenuation values compared to the AGC in both the arterial and portal phases may be useful as a diagnostic feature for differentiating these two on MDCT, which in conjunction with gastroscopy, can improve diagnostic accuracy rates and patient outcome.
1. Kim JP, Lee JH, Kim SJ, Yu HJ, Yang HK. Clinicopathologic characteristics and prognostic factors in 10,783 patients with gastric cancer. Gastric Cancer. 1998; 1: 125-133.
2. Kitamura K, Yamaguchi T, Nishida S, Yamamoto K, Okamoto K, Taniguchi H et al. Early gastric cancer mimicking advanced gastric cancer. Br J Cancer. 1997; 75: 1769-1773.
3. Komori M, Asayama Y, Fujita N, Hiraka K, Tsurumaru D, Kakeji Y, Honda H. Extent of arterial tumor enhancement measured with preoperative MDCT gastrography is a prognostic factor in advanced gastric cancer after curative resection. AJR. 2013; 201(2): 253-61.
4. Hwang SW, Lee DH, Lee SH, Park YS, Hwang JH, Kim JW et al. Preoperative staging of gastric cancer by endoscopic ultrasonography and multidetector-row computed tomography. J Gastroenterol Hepatol 2010; 25: 512-518.
5. Efsen F, Fischerman K. Angiography in gastric tumours. Acta Radiol Diagn. 1974; 15: 193-197.
6. Shibata S, Iwasaki N. Angiographic findings in diseases of the stomach. Am J Roentgenol Radium Ther Nucl Med. 1970; 110: 322-331.
Additional educational material:
Proposed e-poster (ESGAR 2015)EE-038 - Gastrointestinal Wall Lesions : Identified on Routine Transabdominal Ultrasonography.
EuroRad case Nr. 3146
Belo-Oliveira Pedro, Rodrigues Henrique, Belo-Soares Pedro (2005, Jul 13). Polypoid gastric cancer
Comments may be sent directly to Dr. Roulei Chen.
European Association for the Study of the Liver (EASL). EASL Clinical Practice Guidelines on the management of benign liver tumours. J Hepatol. 2016 Apr 11. [Epub ahead of print] doi: 10.1016/j.jhep.2016.04.001
Dr. Federica Vernuccio (University of Palermo/IT)
Prof. Giuseppe Brancatelli (University of Palermo/IT)
With this paper, the aim of the European Association for the Study of the Liver (EASL) was to critically review the existing literature on hepatic hemangioma, focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA), providing official practical recommendations for diagnosis and management of benign focal liver lesions (BLLs).
Hepatic hemangiomas, which are the most common primary liver tumors , may be diagnosed at US if typical findings occur (less of 3 cm in diameter, homogeneously hyperechoic, with sharp margins, posterior enhancement and no halo sign) . In case of oncologic background, underlying liver diseases or atypical features at US, contrast enhanced imaging, possibly through MR, is required for further characterization: it will show a peripheral globular progressive enhancement, with complete filling on delayed phases in cavernous hemangiomas . Using gadoxetic acid on MR, hemangioma shows the so called pseudo wash-out during the transitional and hepatobiliary phases. When imaging is inconclusive, percutaneous biopsy is indicated .
No clinical advices, follow-up or therapy is indicated for hemangiomas except in case of unusual evolutions or complications such as Kasabach-Merrit syndrome, growing lesions or symptomatic lesions due to compression of surrounding organs.
The differential diagnosis of FNH and HCA is mandatory due to their different management. Both these lesions usually occur in young females that are often under oral contraceptives, and can be single or multiple. However, FNH is more common , usually asymptomatic and does not imply any laboratory test abnormality or require any lifestyle change, follow-up, unless there is underlying vascular liver disease, or treatment. On the other hand, HCA may be symptomatic, determine elevation of alcaline phosphatase and transaminase, and patients’ management requires discontinuation of oral contraceptive and weight loss, follow-up  (for women with HCA smaller than 5 cm, an MR examination after 6 months of lifestyle changes, and thereafter at 1 year and annual imaging; in pregnant women, US every 6-12 weeks is indicated) and therapy . Specifically, resection is indicated for HCA in men, for nodules more than 5 cm in diameter or increasing in size more than 20% and in case of beta-catenin mutation because of the higher risk in these cases of potential complications such as hemorrhage and malignant transformation; embolization for bleeding HCA with haemodynamic instability.
For these different approaches, the role of the radiologist is prominent in detection and characterization of these lesions and in the differential diagnosis. Both FNH and HCA do not share unique features on conventional US, and require contrast enhanced imaging (CEUS is preferred for lesions smaller than 3,5 cm , whereas MR is preferred in larger lesions). The main imaging features of FNH at imaging are: lesion homogeneity except the central scar; absence of a capsule; lobulated contours; central scar; slight difference compared to the surrounding liver parenchyma in precontrast imaging; strong and homogeneous enhancement in arterial phase, that becomes similar to that of the adjacent liver parenchyma during portal-venous and delayed phases . Atypias as the presence of steatosis, pseudocapsule and wash out may be encountered. Thus, in a small proportion of patients imaging is inconclusive and liver biopsy is indicated .
The imaging features of HCAs are more variable because HCAs encompass four main different molecular subtypes, as shown in table 2 :
-HCA with inactivation of HNF-1alfa that is responsible for the absence of expression of the liver fatty acid binding protein, resulting in extensive steatosis at pathology and diffuse and homogeneous signal dropout on opposed-phase in chemical shift T1 sequences, moderate enhancement on arterial phase often with washout on portal and/or delayed phases at imaging-
-Inflammatory HCAs, showing inflammatory infiltration and sinusoidal dilatation at pathology and telangectatic features at imaging, that enclose strong hyperintensity on T2-weighted sequences (diffuse or as a rim-like band in the periphery, known as atoll sign), hypervascularity on arterial phase with persistent enhancement on delayed phase. Some atypias may be encountered, as the presence of fat within the lesion, although the signal drop out on opposed phase is heterogenous and moderate.
-HCA with activation of the beta catenin that is responsible of cellular atypias, pseudoglandular formations and cholestasis at pathology.
-Unclassified HCAs, with no specific imaging features.
In conclusion, the EASL guidelines reported in this article provide practical clinical, diagnostic and therapeutical keys for the management of benign liver lesions, that should be known by radiologists in their everyday practice.
1. Kaltenbach TE, Engler P, Kratzer W, Oeztuerk S, Seufferlein T, Haenle MM, Graeter T. Prevalence of benign focal liver lesions: ultrasound investigation of 45,319 hospital patients. Abdom Radiol (NY). 2016;41:25-32.
2. Quaia, E., Bertolotto, M. & Dalla Palma, L. Characterization of liver hemangiomas with pulse inversion harmonic imaging. Eur. Radiol. 2002;12: 537–544
3. Caldironi MW, Mazzucco M, Aldinio MT, Paccagnella D, Zani S, Pontini F, et al. Echo-guided fine-needle biopsy for the diagnosis of hepatic angioma. A report on 114 cases. Minerva Chir 1998;53:505–509
4. Chun YS, Parker RJ, Inampudi S, Ehrenwald E, Batts KP, Burgart LJ, Schumacher CW, Mehling JA, Engstrom BI, Hill MJ, Reddy SK, Sielaff TD. Imaging Surveillance of Hypervascular Liver Lesions in Non-Cirrhotic Patients. J Gastrointest Surg. 2016;20:564-7. doi: 10.1007/s11605-015-2942-9
5. Roche V, Pigneur F, Tselikas L, Roux M, Baranes L, Djabbari M, et al. Differentiation of focal nodular hyperplasia from hepatocellular adenomas with low-mechanical-index contrast-enhanced sonography (CEUS): effect of size on diagnostic confidence. Eur Radiol 2015;25:186–195
6. Buetow PC, Pantongrag-Brown L, Buck JL, Ros PR, Goodman ZD. Focal nodular hyperplasia of the liver: radiologic-pathologic correlation. Radiographics. 1996;16:369-88.
7. Katabathina VS, Menias CO, Shanbhogue AK, Jagirdar J, Paspulati RM, Prasad SR. Genetics and imaging of hepatocellular adenomas: 2011 update. Radiographics. 2011;31:1529-43.
Additional educational material
EuroRad case Nr. 5528 Hepatic Adenoma (HA) and Focal Nodular Hyperplasia (FNH) Grazioli L
Eurorad case Nr 2814 Rapidly filling hemangioma in a cirrhotic patient. Iannaccone R, Marin D, Celestre M, Guerrisi A
Dr. Federica Vernuccio is a third year resident in radiology at the University of Palermo. She has already developed interest toward abdominal imaging, and liver specifically. She has spent 6-months at the Radiology Service of the Beaujon Hospital in Clichy where she is conducting clinical research on hepatocellular adenomas under the mentorship of Prof. Vilgrain.
Comments may be sent directly to Federica Vernuccio.
This paper published in Clinical Gastroenterology and Hepatology by Kwong W.T. et all. in June 2016  aims to determine the rate of pancreatic cancer development from neoplastic pancreatic cysts after 5 years of surveillance.
Dr. Dario Picone (University of Palermo/IT)
Prof. Giuseppe Brancatelli (University of Palermo/IT)
Cystic lesions of the pancreas are increasingly recognized because of the improvement of imaging techniques during the last decades. The prevalence of cystic lesions in the pancreas has been estimated up to 3% using computed tomography (CT) and up to 20% using magnetic resonance (MR) imaging [2-4].
The management of asymptomatic pancreatic cysts is a growing challenge. In almost all cases, pancreatic cysts are incidentally discovered during abdominal imaging for unrelated indications [5-7], and most of them are small, asymptomatic and benign. But they have an established malignant potential [8,9] and need a surveillance which results in significant health care costs [10, 11]. The 2015 American Gastroenterological Association (AGA) guidelines recommend discontinuation of surveillance at 5 years in the absence of significant changes on imaging for asymptomatic neoplastic cysts. The AGA high-risk features are: cystic size > 3 cm; dilated main pancreatic duct > 6 mm; mural nodule.
The most common pancreatic cysts are intraductal papillary mucinous neoplasm (IPMN), mucinous cystic neoplasm and serous cystadenomas.
IPMN represents 20% of cystic lesions of the pancreas  and it is more commonly in men with a mean age of occurrence of 65 years . It is classified on the basis of site of origin of the pancreatic ductal system: main-duct IPMN; side-branch IPMN and mixed IPMN . Its imaging findings are correlated with the subtype of tumor. The main-duct IPMN is characterized by a diffuse or segmental dilatation of the main pancreatic duct; the side-branch IPMN is characterized by a macro or microcyst connected with the main pancreatic duct. While the mixed IPMN can have a combination of features and can be encountered in the main duct and side branches. The presence of mural nodules, focal solid components, enhancement of the wall and main pancreatic duct diameter larger than 18 mm are features suggestive of malignant degeneration within main-duct IPMN. While other malignant feature of side-branch IPMN is the size of the cyst more than 3 cm in diameter .
Mucinous cystic neoplasms have malignant potential and are associated with mucin production  and its histopathological characteristic is the presence of ovarian stroma . It represents 10% of cystic lesion of the pancreas, and it occurs almost exclusively in females, with a mean age of 47 years . The presence of nodules, eggshell calcification, increased wall thickness or irregularity, obstruction or displacement of the main pancreatic duct and a diameter greater than 6 cm suggest malignant transformation .
Serous cystoadenoma represents 20% of cystic lesions of the pancreas  and it is more common in female with a mean age of occurrence of 61 years . The typical imaging finding is a microcystic form, like a honeycomb configuration separated by fibrous septa. Classically, it has been thought that malignant transformation from serous cystadenoma is rare, but the tumor diameter and location of the tumor in the pancreatic head are factors that should merit special consideration when considering clinical management.
In this paper, authors analyzed radiographic and clinical data of 310 patients from four medical centers from 2002 to 2010. The median follow-up was 87 months and the median number of imaging studies per patient was 5. In according to the AGA high-risk features, they calculated the risk of pancreatic cancer for patients: 212 patients 0/3 high-risk features; 85 patients 1/3 high-risk features; 13 patients 2/3 high-risk features; 0 patient 3/3 high-risk features.
The rate of malignant transformation on long-term surveillance (>5 years) among those with 0, 1, and 2 high-risk features was 0%, 1%, and 15%, respectively. During the surveillance (>5 years) there were 29 deaths, and of these deaths, only 3 were correlated to pancreas cancer. Authors compared the disease-specific mortality of pancreatic cysts beyond 5 years to the mortality from other causes, and the results demonstrated that the mortality related to non-pancreatic causes was 8 times higher than mortality owing to pancreatic cancer among patients with neoplastic pancreatic cysts after more than 5 years of surveillance.
In conclusion there is a very low risk of malignant transformation of asymptomatic neoplastic pancreatic cysts after 5 years.
Overall the authors conclude that the discontinuation of surveillance can be considered for patients with pancreatic lesions, and 0 or 1 high-risk feature have a less than 1% risk of developing pancreatic cancer; while surgery or continued surveillance should be considered for patients with neoplastic pancreatic cysts with 2 high-risk features because they have a 15% risk of developing pancreatic cancer.
1. Kwong W .T., Hunt G.C., Fehmi S.E. et all. Low Rates of Malignancy and Mortality in Asymptomatic Patients With Suspected Neoplastic Pancreatic Cysts Beyond 5 Years of Surveillance. Clinical Gastroenterology and Hepatology 2016;14:865–871. doi: 10.1016/j.cgh.2015.11.013. Epub 2015 Dec 2.
2. Del Chiaro M., Verbeke C., Salvia R. the European Study Group on Cystic Tumours of the Pancreas et all . European experts consensus statement on cystic tumours of the pancreas. Digestive and Liver Disease 45 (2013) 703–711.
3. Ip IK, Mortele KJ, Prevedello LM, et al. Focal cystic pancreatic lesions: assessing variation in radiologists management recommendations. Radiology 2011;259:136–41.
4. Laffan TA, Horton KM, Klein AP, et al. Prevalence of unsuspected pancreatic cysts on MDCT. American Journal of Roentgenology 2008;191:802–7.
5. ZhangXM,MitchellDG,DohkeM,etal.Pancreaticcysts:depictiononsingle- shot fast spin-echo MR images. Radiology 2002;223:547–53.
6. Olga R. Brook, MD Peter Beddy, MD Jay Pahade, MD Corey Couto, MD Ian Brennan, MD Payal Patel, MD Alexander Brook, PhD Ivan Pedrosa, MD. Delayed growth in incidental Pancreatic cysts: Are the Current American College of Radiology Recommendations for Follow-up Appropriate?. Radiology 2016; 278:752–761.
7. Laffan TA, Horton KM, Klein AP, et al. Prev- alence of unsuspected pancreatic cysts on MDCT. AJR Am J Roentgenol 2008;191(3): 802–807.
8. Lee KS, Sekhar A, Rofsky NM, Pedrosa I. Prevalence of incidental pancreatic cysts in the adult population on MR imaging. Am J Gastroenterol 2010;105(9):2079–2084.
9. Lee SH, Shin CM, Park JK, et al. Out- comes of cystic lesions in the pancreas after extended follow-up. Dig Dis Sci 2007;52(10):2653–2659.
10. Lahat G, Lubezky N, Haim MB, et al. Cystic tumors of the pancreas: high malignant po- tential. Isr Med Assoc J 2011;13(5):284–289.
11. Tanaka M, Chari S, Adsay V, et al. Interna- tional consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pan- creas. Pancreatology 2006;6(1-2):17–32.
12. Adsay NV. Cystic neoplasia of the pancreas: pathol- ogy and biology. J Gastrointest Surg 2008;12(3): 401–404.
13. Procacci C, Megibow AJ, Carbognin G, et al. Intraductal papillary mucinous tumor of the pan- creas: a pictorial essay. RadioGraphics 1999;19(6): 1447–1463.
14. Manfredi R, Graziani R, Motton M, et al. Main pancreatic duct intraductal papillary mucinous neo- plasms: accuracy of MR imaging in differentiation between benign and malignant tumors compared with histopathologic analysis. Radiology 2009;253 (1):106–115.
15. Campbell F, Azadeh B. Cystic neoplasms of the exocrine pancreas. Histopathology 2008;52(5): 539–551.
16. Al-Haddad M, Schmidt MC, Sandrasegaran K, De- witt J. Diagnosis and treatment of cystic pancreatic tumors. Clin Gastroenterol Hepatol 2011;9(8): 635–648.
17. Compagno J, Oertel JE. Mucinous cystic neoplasms of the pancreas with overt and latent malignancy (cystadenocarcinoma and cystadenoma): a clinico- pathologic study of 41 cases. Am J Clin Pathol 1978; 69(6):573–580.
18. Goh BK, Tan YM, Chung YF, et al. A review of mu- cinous cystic neoplasms of the pancreas de ned by ovarian-type stroma: clinicopathological features of 344 patients. World J Surg 2006;30(12):2236–2245.
19. Crippa S, Salvia R, Warshaw AL, et al. Mucinous cystic neoplasm of the pancreas is not an aggressive entity: lessons from 163 resected patients. Ann Surg 2008;247(4):571–579.
Dr. Dario Picone is a final year resident in radiology at the University of Palermo. His main interest is abdominal radiology, with particular regard to liver and bowel imaging. He has spent part of his training at the Radiology Service of the University College London Hospital and at the Radiology Service of the Beaujon Hospital in Clichy where he focused on prostate cancer imaging and liver imaging respectively.
Comments may be sent directly to Dr. Dario Picone.
Katrijn L M Michielsen, Ignace Vergote, Raphaëla Dresen, Katya Op de Beeck, Ragna Vanslembrouck, Frédéric Amant, Karin Leunen, Philippe Moerman, Steffen Fieuws, Frederik De Keyzer and Vincent Vandecaveye.
Whole-body diffusion-weighted magnetic resonance imaging in the diagnosis of recurrent ovarian cancer: a clinical feasibility study. Br J Radiol. 2016 Nov;89(1067):20160468.
Dr. Max Lahaye – Abdominal Radiologist, The Netherlands Cancer Institute, Amsterdam/NL
The aim of this paper by Michielsen et al. published in the British Journal of Radiology in November 2016 was to assess the clinical feasibility of whole-body diffusion-weighted MRI (WB-DWI/MRI) for diagnosis and prediction of complete tumour resection in patients with suspected recurrent ovarian cancer.
Complete tumour resection (CTR) is essential to maximize the survival of patients with recurrent ovarian cancer. Whether a CTR is feasible is determined by the amount and the localization of disease in the abdomen. The role of CT and fluorine-18 fludeoxyglucose positron emission tomography (18F-FDG-PET)/CT for the detection of recurrent ovarian cancer has been acknowledged.
However, their value for predicting complete resection remains debatable because usually disease load is underestimated [1-3]. Alternative non-invasive methods to reliably determine the surgical resectability are thus desperately needed.
MRI imaging with diffusion-weighted images (DWI-MRI) might be able to determine whether a complete tumour reduction can be achieved. DWI measures the mobility of water molecules to study tissue cellularity. In tissues with increased cellularity (i.e. tumour) the movement of water molecules in the extracellular tissue space is restricted, resulting in an increase in signal on DWI. DWI is a very powerful technique to detect malignant disease, as has been shown by numerous studies in recent years. Whole-body diffusion-weighted MRI (WB-DWI/MRI) has been reported as a promising diagnostic modality for depicting the amount and localization of disease in ovarian cancer, but also in other gynaecological and gastrointestinal (mainly colorectal ) malignancies. However these studies have often small study populations and include a mix of cancer types (colorectal /ovarian) [4-5].
The paper of Michielsen et al. studied a homogenous group of 51 patients with a clinical suspicion of ovarian cancer recurrence. All patients received a CT of thorax/abdomen and WB-DWI/MRI. In this manner the additional value of WB-DWI/MRI over CT could be evaluated in the same group of patients.
WB-DWI/MRI showed 94% accuracy for detecting ovarian cancer recurrence, compared with 78% for CT (p=0.008). In addition, WB-DWI/MRI correctly predicted complete resection in 33 of 35 (94%) patients eligible for salvage surgery compared with only 17 of 35 (49%) for CT (p=0.001). The better prediction of operability by WB-DWI/MRI over CT was mainly attributable to the higher sensitivity for detection of multifocal or diffuse serosal intestinal disease spread, metastases around the central mesenteric vessels and unresectable distant metastases.
These findings are in line with similar studies on primary ovarian cancer, which also showed a high sensitivity for detecting metastases allowing to predict a complete tumor resection [4,6,7]. The current paper by Michielsen et al. adds to these previous data by demonstrating that WB-DWI/MRI could also play an important role in optimizing treatment planning for recurrent ovarian cancer. By improving patient selection, surgeries can thus be omitted in patients who will not benefit from these extensive surgeries with a relative a high rate of morbidity and even mortality.
It would be very interesting to see whether these good results can be reproduced by other centers and also in other cancer types. In order to select the most optimal treatment for advanced cancer patients, intimate knowledge of the extent of disease is paramount. Consequently, the radiologist plays a vital role in the multidisciplinary team of the oncological patient. Upcoming promising techniques like WB-DWI/MRI must therefore be further investigated.
Suggestions for relevant lecture and poster from the ESGAR e-Education Portal:
ESGAR 2016 - LS 7.2 - Whole body MRI for distant staging - advanced stage ovarian, V. Vandecaveye (Leuven, Belgium)
ESGAR 2015 - EE-143 Peritoneal cancer resections - What the radiologist needs to know, 10.5444/esgar2015/EE-143, E. Aherne, H. Fenlon, C.G. Cronin; Dublin/IE
1. Harter P, Sehouli J, Reuss A, Hasenburg A, Scambia G, Cibula D, et al. Prospective validation study of a predictive score for operability of recurrent ovarian cancer: the Multicenter Intergroup Study DESKTOP II. A project of the AGO Kommission OVAR, AGO Study Group, NOGGO, AGO-Austria, and MITO. Int J Gynecol Cancer 2011; 21: 289–95.
2. Lenhard MS, Burges A, Johnson TR, Stieber P, Kumper C, Ditsch N, et al. PET-CT in recurrent ovarian cancer: impact on treatment planning. Anticancer Res 2008; 28: 2303–8.
3. Dragosavac S, Derchain S, Caserta NM, DE Souza G. Staging recurrent ovarian cancer with (18)FDG PET/CT. Oncol Lett 2013; 5: 593–7.
4. Michielsen, K, Vergote, I, Op de Beeck, K, Amant, F, Leunen, K, Moerman P, et al. Whole-body MRI with diffusion-weighted sequence for staging of patients with suspected ovarian cancer: a clinical feasibility study in comparison to CT and FDG-PET/CT, Eur Radiol 2014 24, 889-901.
5. Soussan M, Des Guetz G, Barrau V, Aflalo-Hazan V, Pop G, Mehanna V, et al. Comparison of FDG-PET/CT and MR with diffusion-weighted imaging for assessing peritoneal carcinomatosis from gastrointestinal malignancy, Eur Radiol 2012 22, 1479-1487.
6. Fujii S, Matsusue E, Kanasaki Y, Kanamori Y, Nakanishi J, Sugihara S, et al. Detection of peritoneal dissemination in gynecological malignancy: evaluation by diffusion-weighted MR imaging. Eur Radiol 2008; 18: 18–23.
7. Espada M, Garcia-Flores JR, Jimenez M, Alvarez-Moreno E, De Haro M, GonzalezCortijo L, et al. Diffusion-weighted magnetic resonance imaging evaluation of intraabdominal sites of implants to predict likelihood of suboptimal cytoreductive surgery in patients with ovarian carcinoma. Eur Radiol 2013; 23: 2636–42.
Dr. Max Lahaye is an abdominal radiologist at The Netherlands Cancer Institute, Amsterdam, The Netherlands. He completed his PhD on the prediction of risk factors for a local recurrence in rectal cancer in 2009 and is still involved in research projects on imaging and treatment of colorectal cancer. He has presented multiple scientific talks and lectures at many conferences and has published in high impact radiology journals such as Radiology. Currently, the main focus of his research is on WB-DWI/MRI for staging colorectal and ovarian cancer.
Comments may be sent directly to Dr. Max Lahaye.
Francois Cornelis, Vlasios Storchios, Elena Violari, Constantinos T. Sofocleous, Heiko Schoder, Jeremy C. Durack, Robert H. Siegelbaum, Majid Maybody, John Humm, and Stephen B. Solomon.18F-FDG PET/CT Is an Immediate Imaging Biomarker of Treatment Success After Liver Metastasis Ablation. J Nucl Med 2016; 57:1052–1057
Myrte de Boer – PhD-student (interventional radiology), The Netherlands Cancer Institute / GROW School for Oncology and Developmental Biology - Maastricht University
Doenja Lambregts – Abdominal Radiologist, The Netherlands Cancer Institute/ Antoni van Leeuwenhoek Hospital
The role of thermal ablation techniques like radio frequency ablation (RFA) and microwave ablation (MWA) is emerging for patients with metastatic colorectal cancer. In the European Society for Medical Oncology (ESMO) consensus guidelines for the management of patients with metastatic colorectal cancer from 2016 it is recommended to consider local ablation techniques in patients with unresectable liver metastases. Moreover, it can be used in addition to surgery to eradicate all visible lesions . Although liver ablation is a potentially curative treatment, up to 30-55% of patients show recurrence in the ablation zone, also known as local tumor progression within 1 year. Re-ablation may still result in complete cure in these patients, but only if the (recurrent) metastases are detected in an early stage so that re-ablation is still technically feasible [2, 3]. There is thus an important role for imaging in the early detection of residual and recurrent disease after liver ablation.
The 2010 Cardiovascular and Interventional Radiological Society of Europa (CIRSE) guidelines for RFA of liver tumours advise contrast-enhanced CT or MRI as the standard modalities to assess treatment outcome . An important limitation of these modalities is the difficulty to distinguish between reactive changes in the ablation zone and viable tumour shortly after the ablation. In areas with benign peri-ablational enhancement, small areas of residual tumour can be easily missed. To overcome these limitations, several studies are ongoing that are examining new modalities and methods to detect residual disease or local tumor progression early after ablation in order to allow for timely re-ablation [2, 5]. The currently reviewed paper is an example of such a study, focusing on PET/CT.
The aim of this retrospective study by Cornelis et al., published in the journal of nuclear medicine in July 2016, was to investigate the value of 18F-FDG PET/CT to predict local treatment failure immediately after percutaneous ablation of liver metastases. Twenty-one patients together underwent percutaneous ablation of a total of 25 metastases (the majority of which from colorectal cancer). Contrast-enhanced CT and FDG-PET/CT were performed immediately after the ablation and scored by two readers (in consensus) who assessed the patterns of enhancement (none, ringlike, or nodular) and FDG uptake (none, indeterminate, obvious residual uptake) around the enhancement zone. In addition the PET/CT was quantitatively analyzed as the ‘tissue radioactivity concentration’ (TRC), which was measured for the whole ablation zone, the ablation margins and normalized using the background liver uptake. In total 11/25 lesions recurred locally within one year.
The results of the study showed that the CT enhancement pattern immediately after ablation was a poor predictor of recurrence with a sensitivity of 27%, specificity of 93%, and overall accuracy of 64%, while the uptake pattern on PET/CT showed much better results with a sensitivity of 100%, specificity 86%, and accuracy of 92%. Moreover, the quantitative PET measurements (in specific the normalized TRC measurements) were found to be 100% accurate in predicting a recurrence. As such, the authors concluded that 18F-FDG PET/CT immediately after ablation is superior to CT and appears to be useful for the early detection of residual disease.
A limitation of the study by Cornelis and colleagues – as also acknowledged by the authors in their paper – is that it is a small retrospective study with a potential patient selection bias because the study population mainly consisted of patients who were referred for ablations in difficult salvage situations. Moreover, there was no histopathological validation to confirm recurrent lesions. Nevertheless, the results of this study are promising and it will be interesting to await results of further prospective studies validating the value of PET/CT – as well as other novel imaging techniques that are currently being investigated such as PET-MRI – in this specific setting.
Suggestions for relevant lecture and poster from the ESGAR e-Education Portal:
1. Van Cutsem, E., et al., ESMO consensus guidelines for the management of patients with metastatic colorectal cancer. Ann Oncol, 2016. 27(8): p. 1386-422.
2. Nielsen, K., et al., The use of PET-MRI in the follow-up after radiofrequency- and microwave ablation of colorectal liver metastases. BMC Med Imaging, 2014. 14: p. 27.
3. Poulou, L.S., et al., FDG-PET for detecting local tumor recurrence of ablated liver metastases: a diagnostic meta-analysis. Biomarkers, 2012. 17(6): p. 532-8.
4. Crocetti, L., T. de Baere, and R. Lencioni, Quality improvement guidelines for radiofrequency ablation of liver tumours. Cardiovasc Intervent Radiol, 2010. 33(1): p. 11-7.
5. Cornelis, F., et al., 18F-FDG PET/CT Is an Immediate Imaging Biomarker of Treatment Success After Liver Metastasis Ablation. J Nucl Med, 2016. 57(7): p. 1052-7.
Myrte de Boer recently graduated as a medical doctor at the University of Amsterdam. During her medical studies she co-authored a paper about critically ill patients and gave a lecture at an international conference about the effect of physical activity on breast cancer. Currently she is working as a PhD student at the (interventional) radiology department of the Netherlands Cancer Institute in Amsterdam (the Netherlands) under the supervision of Prof. Regina Beets-Tan and Dr. Monique Maas. The main focus of her thesis is novel imaging strategies for patients undergoing liver ablation (particularly for colorectal liver metastases). Comments may be sent directly to Ms. Myrte de Boer.
J.J. Atema, S.L. Gans, A. Van Randen et al. Comparison of Imaging Strategies with Conditional versus Immediate Contrast-Enhanced Computed Tomography in Patients with Clinical Suspicion of Acute Appendicitis. Eur Radiol. 2015; 25(8): 2445–2452.
Oliver Hulson (Radiology Registrar, St. James’s University Hospital, Leeds/UK)
Damian Tolan (Consultant Radiologist, St. James’s University Hospital, Leeds/UK)
Atema and colleagues from the Netherlands published this paper in European Radiology in April 2015 with a primary aim to, ‘compare the diagnostic accuracy of a conditional CT strategy… versus an immediate CT strategy in adult patients with a clinical suspicion of acute appendicitis’. Whilst the results are from a historic cohort of patients that were collected prospectively as part a multi-centred study published prior to this between 2005 and 2006, the outcomes are still valid and serve to highlight a number of prescient points. The conditional CT strategy is one in which a CT examination is only performed when a prior ultrasound investigation is either negative or inconclusive, whereas an immediate CT strategy is one where, as implied, a CT examination is requested as the first line imaging investigation.
The ultrasound study was performed using both curved 3.5-5.0 MHz and linear 10MHz array probes, using widely accepted features for the diagnosis of acute appendicitis (including a thickened appendix, the presence of an appendicolith and free fluid amongst others). The CT examination was performed with intravenous contrast in the portal venous phase, with no oral or rectal contrast administered. Again, widely accepted imaging features were utilized in the diagnosis of acute appendicitis, but the final diagnosis was at the discretion of the reporting radiologist.
Over the 19-month study period, 422 patients were randomised on a 1:1 ratio to the conditional or immediate CT imaging strategy cohorts. Figure 1 demonstrates flowcharts for both study populations, including the ‘imaging diagnosis’ and ‘final diagnosis’ in both groups. This final diagnosis was assigned to each patient by an expert panel forming a composite assessment, based on histopathology where available, imaging findings, surgical findings and at least 6 months of follow up.
As flowchart A demonstrates, 199/422 (47.2%) patients in the ‘conditional’ group had an ultrasound that was either negative or inconclusive for appendicitis and thus proceeded to CT. Of these 57/199 (28.6%) subsequently were found to be positive for acute appendicitis on CT. A further 10 were given a final diagnosis of appendicitis, despite a negative or inconclusive CT study.
In the immediate CT cohort in Flowchart B, 260/422 (61.6%) patients were diagnosed with appendicitis on CT, with 238 (91.5%) of these cases given a final diagnosis concurring with this.
Table 1 illustrates the diagnostic accuracy of each imaging strategy. Interestingly the conditional CT group had a higher false positive rate of acute appendicitis compared to the immediate CT group, of 14% and 8% respectively, but no p-value was calculated for this. The authors hypothesize that this is a statistical quirk, due to the stepwise nature of the flowchart accumulating both more true and false positives. Otherwise there were no another statistically significant differences between the cohorts. Importantly, the sensitivity and specificity for both cohorts were broadly similar (with the specificity a little higher for the immediate CT strategy), as were the number of missed cases and the negative and positive predictive values.
The study justifies the use of ultrasound as the first line imaging investigation in adult patients being assessed for acute appendicitis. Numerous studies have highlighted the increasing dependence on CT in the assessment of the acute abdomen(1)(2), and acute appendicitis is generally regarded as a pathology predominantly, but not exclusively, affecting young people. This is particularly important as a number of papers have been published recently highlighting the long-term effects of clinical radiation exposure, in particular the potential increased lifetime cancer risk(3),(4). If the diagnosis can be achieved, or an alternative cause for the patient’s symptoms established without the use of CT, then these potentially harmful effects of ionizing radiation are obviously avoided.
Having said that, the sonographic diagnosis of appendicitis can be challenging and other studies have demonstrated significant operator-dependence and interobserver variability(5). However this trial took place across a wide number of institutions and a large number of radiologists which strengthens its wider applicability. Another potential issue arises in the surgeons’ mistrust of ultrasound in this context(6), and it can envisaged that a number of CT requests will arise in real life clinical practice in order to prove or disprove the sonographic findings.
Ultimately, each patient’s assessment and the imaging strategy employed should take into account the clinical presentation, examination findings and laboratory investigations to achieve the diagnosis. By working closely with surgical colleagues, and offering the most appropriate imaging modality for that particular case, it is hoped that the most rational imaging strategy is employed, and the use of ionizing radiation is kept as low as reasonably applicable. As Atema and colleagues suggest, ultrasound as the first line imaging investigation seems a rational and cost effective approach for the assessment of uncomplicated acute appendicitis. It will be interesting to see whether health care service commissioners see this research and mandate radiologists to improve their ultrasound skills to reduce cost and radiation for this patient group.
Dr. Oliver Hulson is a final year registrar on the West Yorkshire radiology training scheme in the UK. He completed his undergraduate medical degree at the University of Leeds. He has a keen interest in training and education, completing his MSc in Clinical Education through the University of Edinburgh alongside his clinical studies. He has presented at a number of international radiology meetings, has published in Paediatric Radiology and provided a number of radiology teaching cases for the British Medical Journal.
Additional educational materials:
EURORAD Case Nr.: 12077 - Femoral hernial sac containing inflamed appendix: De Garengeot's hernia
ESGAR 2013: SE-080 Free-hand sonoelastographic evaluation of appendicitis
G. Pekindil, T. Coskun; Manisa/TR
ESGAR 2014: WS 22.01 - Acute lower abdominal pain
M. D'Onofrio (Verona, Italy)
1. Brown J, Shesser R. Computed tomography scan use in the emergency department evaluation of patients with nonspecific abdominal pain. Ann Emerg Med. 2004 Oct;44(4):S32.
2. Larson DB, Johnson LW, Schnell BM, Salisbury SR, Forman HP. National Trends in CT Use in the Emergency Department: 1995–2007 1. Radiology. 2011;258(1):164–73.
3. Brenner D, Hall E. Computed tomography--an increasing source of radiation exposure. N Engl J Med. 2007 Nov;29(357):2277–84.
4. Pearce M, Salotti J, Little M, McHugh K. Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study. The Lancet. 2012 Aug;380(9840):499–505.
5. Pinto F, Pinto A, Russo A, Coppolino F, Bracale R, Fonio P, et al. Accuracy of ultrasonography in the diagnosis of acute appendicitis in adult patients: review of the literature. Crit Ultrasound J. 2013;5(Suppl 1):S2.
6. Exadaktylos AK, Sadowski-Cron C, Mader P, Weissmann M, Dinkel HP, Negri M, et al. Decision making in patients with acute abdominal pain at a university and at a rural hospital: Does the value of abdominal sonography differ? World J Emerg Surg. 2008;3(1):29.
You can send your comments directly to Dr. Oliver Hulsen.
Furuhashi N, Suzuki K, Sakurai Y et al. Differentiation of focal-type autoimmune pancreatitis from pancreatic carcinoma: assessment by multiphase contrast-enhanced CT. Eur Radiol. 2015; 25: 1366-1374.
Dr. Gemma Miles (Radiology Registrar, Derriford Hospital, Plymouth/UK)
Dr. Simon Jackson (Consultant GI Radiologist, Derriford Hospital, Plymouth/UK)
This paper published in the European Journal of Radiology by Furhashi et al in May 2015 aims to determine the use of increasingly recognised multiphase contrast enhanced CT (CECT) features (both alone and in combination) to differentiate focal-type autoimmune pancreatitis (f-AIP) from pancreatic cancer. This retrospective, single centre study adds to emerging characteristic CECT data, useful in the interrogation of the diagnostically challenging f-AIP, where CT is the commonest first-line investigation for characterisation.
Previous studies have demonstrated various highly specific CECT imaging findings seen in focal-type AIP, which however remain of low sensitivity when considered alone. The authors demonstrate considerable increase in diagnostic sensitivity when used in combination.
A retrospective review of the standard quadruple-phase (pre-, pancreatic, portal venous and delayed phase) CECT imaging of the pancreas of two cohorts of patients; with focal AIP and pancreatic cancer, was carried out by two radiologists, blinded to the final diagnosis, demographic data and other examination findings (e.g. levels of serum IgG4 and CA19-9). The patients were initially identified from their institutions database of pancreatic and biliary system CT examinations.
Following a small number of exclusions, CECT examinations of the pancreas of twenty-two f-AIP lesions diagnosed between January 2007 and August 2012 were evaluated (the AIP diagnosis was made on the basis of International Consensus Diagnostic Criteria and Revised Japanese Pancreas Society criteria)1, whilst sixty-one histologically confirmed cases of pancreatic cancer surgically resected between November 2010 and August 2012 were compared. The authors defined a ‘focal’ lesion as “a mass-forming, focal enlargement or abnormal enhancement of the pancreas within a third of the pancreas”.
The lesion size (maximum diameter), location and enhancement patterns were assessed as seen in the table below…(TABLE 2), with previously described specific parenchymal enhancement features also commented upon within the affected pancreas including dotted enhancement in the pancreatic phase, duct penetrating sign (the main pancreatic duct visible within the lesion) – previously described by Ichikawa in 20012 on MRCP and enhanced duct sign (wall enhancement of the main pancreatic duct within the lesion).
Further assessment was made on the presence of a peri-pancreatic capsule-like rim, calcification, cyst formation and vascular involvement (as usually assessed with pancreatic neoplasms).
Peri-pancreatic strands (>10mm in length) – as described by Matsumoto et al in 2012 with respect to pancreatic body and tail carcinoma 3 were also identified.
The presence/absence of main pancreatic duct upstream dilatation and distal atrophy were commented upon within the unaffected gland. The absence of upstream main pancreatic duct dilatation in the presence of stenoses having been previously demonstrated on MR/MRCP 4.
Finally various characteristics with regard to the bile duct were assessed.
In both f-AIP and pancreatic carcinoma the majority of lesions were present within the head (82% and 74% respectively). The f-AIP lesions were overall significantly larger (35+/- 11mm in f-AIP compared with 25+/- 9mm in pancreatic cancer) (p<0.001).
In addition, significant differences in enhancement were demonstrated between the two groups; with f-AIP more frequently showing homogenous enhancement in both portal venous and delayed phases compared with pancreatic carcinoma, which showed heterogeneous decreased enhancement in both phases. This conforms the findings of previous studies. There was also a significant increase in frequency of dotted enhancement in the pancreatic phase, duct-penetrating sign, enhancing duct sign and capsule-like rim in f-AIP compared with pancreatic carcinoma. All of these findings demonstrated high specificities in the region of 0.93-0.98 but relatively low sensitivities (0.36-0.59)
Furthermore, ring-like enhancement during delayed phase and peri-pancreatic strands were significantly more common in the pancreatic cancer cohort. These features demonstrated considerable sensitivity (0.95) however limited specificities of 0.39-0.46. Whilst individual findings were not able to show both high sensitivity and specificity, the authors demonstrated by combining three-four of these significant CT features, up to 0.91 sensitivity and 0.98 specificity, with accuracies in the region of 0.94. In general there was reasonable reproducibility of the significant CT findings (moderate-good inter-observer agreement) with the exception of enhancement patterns during the pancreatic phase (K=0.24).
Interestingly, there was no significant difference identified between the two in the presence of calcification, cyst formation, vascular involvement, upstream dilatation of the main pancreatic duct and distal atrophy. No significant differences were identified within CBD features in either stented or non-stented patients.
This study adds to the growing radiological experience of differentiating focal AIP from pancreatic cancer, essential to avoid unnecessary surgical resections and their potential considerable morbidity. The study confirms similar CECT features of f-AIP, previously described on MR/MRCP such as duct-penetrating sign and dotted enhancement during the pancreatic phase 5 which the authorspostulate represents residual normal or mildly involved pancreatic lobules within a lesion. In addition this study further reinforces the significance of previously described CECT signs such as enhanced-duct sign, showing high specificity (0.98) compared with pancreatic carcinoma.
As one might expect, and confirmed by this study, when three or more of the significant CT features are considered together there is a considerable increase in sensitivity.
Furthermore, as the authors suggest, in reality, reviewing the entire scan, to identify extra-pancreatic manifestations of IgG4 disease and considering both the biochemical and clinical findings, would clearly enhance diagnostic accuracy of f-AIP. In equivocal cases, the importance of multi-modality imaging and specialist hepato-pancreaticobilliary MDT discussion should not be underestimated.
1. Shimosegawa T, Chiari ST, Frulloni L et al (2011). International consensus diagnostic criteria for autoimmune pancreatitis: guidelines of the International Association of Pancreatology. Pancreas 40:352-358.
2. Ichikawa T, Sou H, Araki T et al (2001). Duct-penetrating sign at MRCP: usefulness for differentiating inflammatory pancreatic mass from pancreatic carcinomas. Radiology 221:107-116.
3. Matsumoto S, Mori H, Kiyonaga M et al (2012). “Peripancreatic strands appearance” in pancreatic body and tail carcinoma: evaluation by multi-detector CT with pathological correlation, Abdom Imaging 37: 602-608.
4. Negrelli R, Manfredi R, Pedrinolla B et al (2015). Pancreatic duct abnormalities in focal AIP: MR/MRCP imaging findings. Eur Radiol 25(2):359-67.
5. Sugiyama Y, Fujinaga Y, Kadoya M et al (2012). Characteristic magnetic resonance features of focal autoimmune pancreatitis useful for differentiation from pancreatic cancer. Jpn Radiol 30:296-309.
Additional educational material:
EURORAD Case No: 5373 – A case of focal autoimmune pancreatitis.
Corriero A, Pratali A, Cappelli C, Caproni G, Battaglia V, Forasassi F, Mazzeo S, Bartolozzi C.et al.
ESGAR 2015: LS 2.3 – Autoimmune pancreatitis.
SA Jackson (Plymouth/UK)
ESGAR 2014, Cum Laude e-poster: EE-138 Autoimmune Pancreatitis – the Clinicoradiological Story So Far.
G. Miles, T. Adlan, F. Wotton, S.A. Jackson.
Dr. Gemma Miles is a final year registrar on the Peninsula radiology training scheme in the UK, having completed her undergraduate medical degree and intercalated BSc at Imperial College, London. She is currently undertaking an MSc in Clinical Leadership, Management and Innovation through the University of Plymouth. She has previously undertaken research into the correlation of CT with histopathological outcome in the assessment of tumour origin in pancreatic cancer, with work presented at a number of international meetings. She achieved a Cum Laude award at ESGAR 2014 for her e-Poster on autoimmune pancreatitis and in addition has published articles in Emergency Radiology, Journal of Clinical Ultrasound and Imaging.
Comments may be sent directly to Dr. Gemma Miles.
M.H. Martens, M.M. van Heeswijk, J.J. van den Broek, et al. Prospective, multicenter validation study of magnetic resonance volumetry for response assessment after preoperative chemoradiation in rectal cancer: can the results in the literature be reproduced? Int J Radiat Oncol Biol Phys 2015;93:1005-1014.
Monique Maas – Radiology Registrar, Maastricht University Medical Centre
Doenja Lambregts – Radiology Registrar, Maastricht University Medical Centre / The Netherlands Cancer Institute
The aim of this paper published in the Red Journal (International Journal of Radiation Oncology Biology Physics) in December 2015 by Martens et al. is twofold: (1) to review existing literature on tumour size and volume measurements on MRI for assessment of response to chemoradiotherapy in rectal cancer and (2) prospectively validate different size and volume cut-offs derived from literature in an independent cohort of patients.
Response assessment in rectal cancer is an emerging topic. As pointed out in a meta-analysis from 2013 by van der Paardt et al. published reports show heterogeneous results for the restaging of rectal cancer after chemoradiotherapy (CRT) on morphological MRI.1 The main issue is that in irradiated patients it is difficult to differentiate between post-treatment fibrosis and areas of viable residual tumour. As such, there is a need for additional tools to improve the diagnostic performance of imaging in assessing response, which is stressed by the increasing interest for organ preserving treatment. With organ-preservation, patients with a good or complete tumour response are deferred from surgery and undergo a local excision or even a ‘watch-and-wait’ policy. Selection of the right patients is one of the most important challenges, which requires an accurate response assessment after CRT.2,3
An approach that has often been studied is to measure changes in the size and/or volume of rectal tumours on MRI as a predictor of response. However, methodology, study outcomes and results vary considerably amongst the published reports, making it difficult to draw conclusions regarding its potential clinical diagnostic value. The paper by Martens et al. aimed to shed some light on this matter. They included 14 papers in their retrospective review and subdivided these into papers that used one-dimensional size measurements (tumour length), 3-dimensional size measurements (length x anteroposterior diameter x left-right diameter) and whole volume measurements. The outcome measures of response were the histopathological tumour regression grade, complete pathologic response vs. residual tumour and T-downstaging (downstaging of the tumour at histopathology compared to the initial cT-stage). Optimal size and volume thresholds were derived from these studies and prospectively tested in a new cohort of 146 patients from 4 different centres. The study findings for the literature review and corresponding prospective validation are presented in Table 3. The main conclusions from the authors were that one-dimensional and 3-dimensional size measurements are not of any clinical benefit in assessing response. Accuracies for one-dimensional measurement ranged between 53% and 68% in the literature review and dropped to 48-53% in the prospective validation. Similarly, results for the 3-dimensional measurements ranged between 53-79% in literature and 52-56% in the prospective validation. Best results were found for whole-volume tumour measurements. Whole-volume tumour measurements were particularly valuable in identifying patients with a complete tumour response with accuracies of up to 88% reported in literature, which could be reproduced with accuracies up to 80% in the prospective validation cohort.
Despite these relatively high overall accuracies, the main issue for clinical practice is the rather disappointing sensitivities to select complete responders, which – as illustrated in Table 3 – often not exceed 50%. Such a low sensitivity will result in missing a substantial part of the complete responders. On the other hand, the high specificity of around 90% shows that the risk for missing residual tumour is very low. All together the value of T2W-volumetry to identify patients eligible for a watch-and-wait policy appears to be limited, apart from the fact that whole volume tumour measurements are quite time consuming and therefore unpractical for daily routine.
Additionally, this paper only focuses on MR-volumetry using T2-weighted MRI. Several studies have demonstrated that diffusion-weighted MRI is more accurate than T2-weighted MRI in identifying residual tumour after CRT.1,4 Moreover, recent reports have shown promising results for DWI-volumetry, with improved sensitivities and similar specificities compared to T2W-volumetry for selecting complete responders.5,6 As such, DWI-volumetry may be of more value in clinical practice than T2W-volumetry.
As the authors acknowledge, nodal staging was not a part of this study, but of course is very relevant for assessment of a complete response.
1. van der Paardt MP, Zagers MB, Beets-Tan RG, Stoker J, Bipat S. Patients Who Undergo Preoperative Chemoradiotherapy for Locally Advanced Rectal Cancer Restaged by Using Diagnostic MR Imaging: A Systematic Review and Meta-Analysis. Radiology 2013;269:101-112.
2. Habr-Gama A, Perez RO, Nadalin W, et al. Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy: long-term results. Ann Surg 2004;240:711-717; discussion 717-718.
3. Lezoche G, Baldarelli M, Guerrieri M, et al. A prospective randomized study with a 5-year minimum follow-up evaluation of transanal endoscopic microsurgery versus laparoscopic total mesorectal excision after neoadjuvant therapy. Surg Endosc 2008;22:352-358
4. Kim SH, Lee JM, Hong SH, et al. Locally advanced rectal cancer: added value of diffusion-weighted MR imaging in the evaluation of tumor response to neoadjuvat chemo- and radiation therapy. Radiology 2009;253:116-125
5. Curvo-Semedo L, Lambregts DM, Maas M, et al. Rectal cancer: assessment of complete response to preoperative combined radiation therapy with chemotherapy--conventional MR volumetry versus diffusion-weighted MR imaging. Radiology 2011;260:734-743.
6. Ha HI, Kim AY, Yu CS, Park SH, Ha HK. Locally advanced rectal cancer: diffusion-weighted MR tumour volumetry and the apparent diffusion coefficient for evaluating complete remission after preoperative chemoradiation therapy. Eur Radiol 2013;23:3345-3353.
Dr. Monique Maas is a final year registrar at Maastricht University Medical Centre (The Netherlands). She completed her PhD on organ preserving treatment in rectal cancer in 2013 and is still involved in research projects on imaging and treatment of rectal cancer, in which she mainly focuses on the value of imaging to select patients for organ preservation. She has presented scientific talks and lectures at many conferences and has published in high impact journals such as The Lancet Oncology and the Journal of Clinical Oncology. Currently she is supervising PhD students in the field of rectal cancer imaging.